FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985996265> ?p ?o ?g. }

• W1985996265 endingPage "528" @default.
• W1985996265 startingPage "517" @default.
• W1985996265 abstract "The antitumour effects of flavone acetic acid (FAA) against a broad spectrum of established experimental tumours has been demonstrated. Damage to the vasculature, which rapidly disrupts blood flow and induces haemorrhagic necrosis, is believed to be a major mechanism contributing to the observed antitumour effects. Despite these established observations, FAA has shown little effect against human tumours. However, other applications of FAA, for examples, for an extended period of treatments or in combination with other antitumour modalities, have not been sufficiently explored. In order to test the direct effects of FAA on vasculature, endothelial cells isolated from human umbilical vein (HUVEC) and bovine pulmonary artery (CPAEC) were used in this study. FAA at the concentrations of 50 to 200 micrograms/ml causes reduction in cell number (from 20 to > 30% of the cells) of HUVEC as measured by MTT assay after 1, 3, and 5 h of treatment at 37 degrees C. FAA did not produce significant effects on similarly treated human squamous cell carcinoma, cell line UM-SCC-2. After 1 h treatment of FAA at 300 micrograms/ml, a large number of HUVECs failed to react with an actin stain, NBD-phallacidin. The growth of HUVECs and CPAEC in the presence of FAA for 1-3 days was progressively reduced. The number of HUVEC treated for 3 days at the concentrations of 100, 200, and 300 micrograms/ml were reduced by 75-86% in comparison with the control culture. The experiments with CPAEC showed similar results. The inhibition of the growth of endothelial cells by FAA was enhanced when it combines with tumour necrosis factor-alpha but not with interleukin-1, interferon-gamma, heat, or radiation. We observed that FAA can initiate both immediate effects and growth inhibition on cultured endothelial cells. These results support the notion that FAA rapidly induces vasculature damage. Furthermore, cytokines such as tumour necrosis factor-alpha can enhance the toxicity of FAA on endothelial cells." @default.
• W1985996265 created "2016-06-24" @default.
• W1985996265 creator A5067928280 @default.
• W1985996265 creator A5068838521 @default.
• W1985996265 creator A5085768397 @default.
• W1985996265 date "1993-01-01" @default.
• W1985996265 modified "2023-09-23" @default.
• W1985996265 title "Combined treatments of heat, radiation, or cytokines with flavone acetic acid on the growth of cultured endothelial cells" @default.
• W1985996265 cites W1974302749 @default.
• W1985996265 cites W2000719340 @default.
• W1985996265 cites W2005473006 @default.
• W1985996265 cites W2007551831 @default.
• W1985996265 cites W2012479775 @default.
• W1985996265 cites W2013456954 @default.
• W1985996265 cites W2016288657 @default.
• W1985996265 cites W2019565242 @default.
• W1985996265 cites W2035143126 @default.
• W1985996265 cites W2043032770 @default.
• W1985996265 cites W2046417203 @default.
• W1985996265 cites W2047643243 @default.
• W1985996265 cites W2057910790 @default.
• W1985996265 cites W2078385909 @default.
• W1985996265 cites W2089293590 @default.
• W1985996265 cites W2114280629 @default.
• W1985996265 cites W2130906103 @default.
• W1985996265 cites W2157603347 @default.
• W1985996265 cites W2163371697 @default.
• W1985996265 doi "https://doi.org/10.3109/02656739309005049" @default.
• W1985996265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8366302" @default.
• W1985996265 hasPublicationYear "1993" @default.
• W1985996265 type Work @default.
• W1985996265 sameAs 1985996265 @default.
• W1985996265 citedByCount "6" @default.
• W1985996265 countsByYear W19859962652021 @default.
• W1985996265 crossrefType "journal-article" @default.
• W1985996265 hasAuthorship W1985996265A5067928280 @default.
• W1985996265 hasAuthorship W1985996265A5068838521 @default.
• W1985996265 hasAuthorship W1985996265A5085768397 @default.
• W1985996265 hasConcept C123012128 @default.
• W1985996265 hasConcept C153911025 @default.
• W1985996265 hasConcept C16685009 @default.
• W1985996265 hasConcept C185592680 @default.
• W1985996265 hasConcept C202751555 @default.
• W1985996265 hasConcept C203014093 @default.
• W1985996265 hasConcept C2777411675 @default.
• W1985996265 hasConcept C54355233 @default.
• W1985996265 hasConcept C55493867 @default.
• W1985996265 hasConcept C62112901 @default.
• W1985996265 hasConcept C71924100 @default.
• W1985996265 hasConcept C81885089 @default.
• W1985996265 hasConcept C86803240 @default.
• W1985996265 hasConcept C98274493 @default.
• W1985996265 hasConceptScore W1985996265C123012128 @default.
• W1985996265 hasConceptScore W1985996265C153911025 @default.
• W1985996265 hasConceptScore W1985996265C16685009 @default.
• W1985996265 hasConceptScore W1985996265C185592680 @default.
• W1985996265 hasConceptScore W1985996265C202751555 @default.
• W1985996265 hasConceptScore W1985996265C203014093 @default.
• W1985996265 hasConceptScore W1985996265C2777411675 @default.
• W1985996265 hasConceptScore W1985996265C54355233 @default.
• W1985996265 hasConceptScore W1985996265C55493867 @default.
• W1985996265 hasConceptScore W1985996265C62112901 @default.
• W1985996265 hasConceptScore W1985996265C71924100 @default.
• W1985996265 hasConceptScore W1985996265C81885089 @default.
• W1985996265 hasConceptScore W1985996265C86803240 @default.
• W1985996265 hasConceptScore W1985996265C98274493 @default.
• W1985996265 hasIssue "4" @default.
• W1985996265 hasLocation W19859962651 @default.
• W1985996265 hasLocation W19859962652 @default.
• W1985996265 hasOpenAccess W1985996265 @default.
• W1985996265 hasPrimaryLocation W19859962651 @default.
• W1985996265 hasRelatedWork W1834476006 @default.
• W1985996265 hasRelatedWork W2045505273 @default.
• W1985996265 hasRelatedWork W2122216055 @default.
• W1985996265 hasRelatedWork W2246462199 @default.
• W1985996265 hasRelatedWork W2348599162 @default.
• W1985996265 hasRelatedWork W2384753871 @default.
• W1985996265 hasRelatedWork W2387407221 @default.
• W1985996265 hasRelatedWork W2413532914 @default.
• W1985996265 hasRelatedWork W2744055887 @default.
• W1985996265 hasRelatedWork W2990659495 @default.
• W1985996265 hasVolume "9" @default.
• W1985996265 isParatext "false" @default.
• W1985996265 isRetracted "false" @default.
• W1985996265 magId "1985996265" @default.
• W1985996265 workType "article" @default.