FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985998919> ?p ?o ?g. }

• W1985998919 endingPage "1257" @default.
• W1985998919 startingPage "1247" @default.
• W1985998919 abstract "Dehydroepiandrosterone 3-sulfate and other neurosteroids are synthesized in the CNS and peripheral nervous system where they may modulate neuronal excitability by interacting with ligand-gated ion channels. For this modulatory activity, neurosteroids have to be locally released from either neurons or glial cells. We here identify the integral membrane protein ABCC11 (multidrug resistance protein 8) as an ATP-dependent efflux pump for steroid sulfates, including dehydroepiandrosterone 3-sulfate, and localize it to axons of the human CNS and peripheral nervous system. ABCC11 mRNA was detected in human brain by real-time polymerase chain reaction. Antibodies raised against ABCC11 served to detect the protein in brain by immunoblotting and immunofluorescence microscopy. ABCC11 was preferentially found in the white matter of the brain and co-localized with neurofilaments indicating that it is an axonal protein. Additionally, ABCC11 was localized to axons of the peripheral nervous system. For functional studies, ABCC11 was expressed in polarized Madin-Darby canine kidney cells where it was sorted to the apical membrane. This apical sorting is in accordance with the localization of ABCC11 to the axonal membrane of neurons. Inside-out plasma membrane vesicles containing recombinant ABCC11 mediated ATP-dependent transport of dehydroepiandrosterone 3-sulfate with a Km value of 21 μM. This transport function together with the localization of the ABCC11 protein in vicinity to GABAA receptors is consistent with a role of ABCC11 in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation. Our findings may provide a basis for the characterization of mutations in the human ABCC11 gene and their linkage with neurological disorders." @default.
• W1985998919 created "2016-06-24" @default.
• W1985998919 creator A5002662351 @default.
• W1985998919 creator A5025477516 @default.
• W1985998919 creator A5029302293 @default.
• W1985998919 creator A5038325026 @default.
• W1985998919 creator A5038966919 @default.
• W1985998919 creator A5065181138 @default.
• W1985998919 date "2006-01-01" @default.
• W1985998919 modified "2023-10-15" @default.
• W1985998919 title "Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system" @default.
• W1985998919 cites W109648843 @default.
• W1985998919 cites W1481077857 @default.
• W1985998919 cites W1511819831 @default.
• W1985998919 cites W1516142101 @default.
• W1985998919 cites W1534552882 @default.
• W1985998919 cites W1550917147 @default.
• W1985998919 cites W1721237546 @default.
• W1985998919 cites W1788032165 @default.
• W1985998919 cites W1819465909 @default.
• W1985998919 cites W1876100479 @default.
• W1985998919 cites W1976917710 @default.
• W1985998919 cites W1980679007 @default.
• W1985998919 cites W1987598198 @default.
• W1985998919 cites W1991369024 @default.
• W1985998919 cites W1999004536 @default.
• W1985998919 cites W1999278068 @default.
• W1985998919 cites W2005064657 @default.
• W1985998919 cites W2012618926 @default.
• W1985998919 cites W2020441233 @default.
• W1985998919 cites W2024335250 @default.
• W1985998919 cites W2028466691 @default.
• W1985998919 cites W2028899000 @default.
• W1985998919 cites W2030542269 @default.
• W1985998919 cites W2033399202 @default.
• W1985998919 cites W2034846190 @default.
• W1985998919 cites W2039083593 @default.
• W1985998919 cites W2039299884 @default.
• W1985998919 cites W2040315766 @default.
• W1985998919 cites W2042674837 @default.
• W1985998919 cites W2043338020 @default.
• W1985998919 cites W2053575220 @default.
• W1985998919 cites W2053706150 @default.
• W1985998919 cites W2064064687 @default.
• W1985998919 cites W2066385861 @default.
• W1985998919 cites W2066896396 @default.
• W1985998919 cites W2070510853 @default.
• W1985998919 cites W2070972281 @default.
• W1985998919 cites W2076893872 @default.
• W1985998919 cites W2078837666 @default.
• W1985998919 cites W2080320008 @default.
• W1985998919 cites W2081048081 @default.
• W1985998919 cites W2082972630 @default.
• W1985998919 cites W2083447043 @default.
• W1985998919 cites W2094699302 @default.
• W1985998919 cites W2094761998 @default.
• W1985998919 cites W2103044032 @default.
• W1985998919 cites W2106762675 @default.
• W1985998919 cites W2106799985 @default.
• W1985998919 cites W2108425243 @default.
• W1985998919 cites W2116400584 @default.
• W1985998919 cites W2117791851 @default.
• W1985998919 cites W2121413314 @default.
• W1985998919 cites W2124895322 @default.
• W1985998919 cites W2164052057 @default.
• W1985998919 cites W2166610424 @default.
• W1985998919 cites W2239977054 @default.
• W1985998919 cites W2256895060 @default.
• W1985998919 cites W4245117662 @default.
• W1985998919 cites W4253824341 @default.
• W1985998919 cites W43589343 @default.
• W1985998919 doi "https://doi.org/10.1016/j.neuroscience.2005.10.025" @default.
• W1985998919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16359813" @default.
• W1985998919 hasPublicationYear "2006" @default.
• W1985998919 type Work @default.
• W1985998919 sameAs 1985998919 @default.
• W1985998919 citedByCount "78" @default.
• W1985998919 countsByYear W19859989192012 @default.
• W1985998919 countsByYear W19859989192013 @default.
• W1985998919 countsByYear W19859989192014 @default.
• W1985998919 countsByYear W19859989192015 @default.
• W1985998919 countsByYear W19859989192016 @default.
• W1985998919 countsByYear W19859989192017 @default.
• W1985998919 countsByYear W19859989192018 @default.
• W1985998919 countsByYear W19859989192019 @default.
• W1985998919 countsByYear W19859989192020 @default.
• W1985998919 countsByYear W19859989192021 @default.
• W1985998919 countsByYear W19859989192022 @default.
• W1985998919 countsByYear W19859989192023 @default.
• W1985998919 crossrefType "journal-article" @default.
• W1985998919 hasAuthorship W1985998919A5002662351 @default.
• W1985998919 hasAuthorship W1985998919A5025477516 @default.
• W1985998919 hasAuthorship W1985998919A5029302293 @default.
• W1985998919 hasAuthorship W1985998919A5038325026 @default.
• W1985998919 hasAuthorship W1985998919A5038966919 @default.
• W1985998919 hasAuthorship W1985998919A5065181138 @default.
• W1985998919 hasConcept C126322002 @default.
• W1985998919 hasConcept C134018914 @default.

• next