FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986005204> ?p ?o ?g. }

• W1986005204 endingPage "784" @default.
• W1986005204 startingPage "763" @default.
• W1986005204 abstract "Secretory immunoglobulin A is the characteristic and predominant immunoglobulin of the mucosal immune system; it participates in immunological protection at the level of mucous membrane surfaces. During the past 10 to 15 years, a great deal of experimental and clinical evidence has shown that the liver is very much involved in the sIgA system. In certain animals (rats, mice, rabbits), polymeric forms of IgA are efficiently cleared by the liver and transported into bile by a receptor-mediated vesicular pathway across hepatocytes. Taking advantage of this easily accessible pathway, investigators have defined many of the events in the external secretion of pIgA, including details about the synthesis and secretion of its receptor, secretory component. In the rat hepatocyte, secretory component is synthesized as a transmembrane glycoprotein and is expressed preferentially on the sinusoidal plasma membrane; circulating pIgA that binds to secretory component is internalized into endocytic vesicles and transported across the hepatocyte to the bile canalicular membrane, where the pIgA is released into bile as a soluble complex with a portion of the secretory component, the complex being secretory IgA. In some other animals (dog, guinea pig, sheep) as well as man, biliary epithelial cells, not hepatocytes, express secretory component and perform the transcytosis and secretion of pIgA into bile. In those species, much of the pIgA that reaches bile is synthesized locally in plasma cells that populate the biliary tree; this design is analogous to the release of sIgA into various mucosae in the body. The major biological functions ascribed to the secretion of IgA into bile are enhancement of immunological defense of the biliary and upper intestinal tracts and the clearance of harmful antigens from the circulation as IgA-antigen complexes. However, the importance of biliary IgA antibodies is largely unclarified, and man lacks the capacity for effective clearance of IgA-antigen complexes via the secretory component-mediated transhepatocellular pathway; whether this deficit contributes to the propensity for man to develop IgA immune complex diseases should be clarified. Among liver diseases, alcoholic disease is most closely linked to alterations in IgA metabolism. This association is manifested principally by the deposition of IgA along the sinusoids in the livers of the majority of alcoholics and in the renal mesangium of many. The IgA1 subclass of IgA predominates in the IgA deposits in both tissues; the possibility that this predominance is related to abnormalities in the removal of circulating IgA1 by asialoglycoprotein receptors on hepatocytes is an intriguing consideration. Thus, the liver plays a unique role in mucosal immunity and in the physiology of IgA in normal and disease states. Further study of the associations between the liver and IgA, particularly in man, is clearly needed." @default.
• W1986005204 created "2016-06-24" @default.
• W1986005204 creator A5083139340 @default.
• W1986005204 creator A5084598758 @default.
• W1986005204 date "1989-05-01" @default.
• W1986005204 modified "2023-10-06" @default.
• W1986005204 title "The liver and IgA: Immunological, cell biological and clinical implications" @default.
• W1986005204 cites W147083834 @default.
• W1986005204 cites W1485381776 @default.
• W1986005204 cites W1517509499 @default.
• W1986005204 cites W1517922196 @default.
• W1986005204 cites W1521905687 @default.
• W1986005204 cites W1527182158 @default.
• W1986005204 cites W1528669392 @default.
• W1986005204 cites W1537481887 @default.
• W1986005204 cites W1539599326 @default.
• W1986005204 cites W1540378730 @default.
• W1986005204 cites W1542880421 @default.
• W1986005204 cites W1551647770 @default.
• W1986005204 cites W1552550319 @default.
• W1986005204 cites W1553501445 @default.
• W1986005204 cites W1566307488 @default.
• W1986005204 cites W1574226497 @default.
• W1986005204 cites W1580446964 @default.
• W1986005204 cites W1580742681 @default.
• W1986005204 cites W1586558668 @default.
• W1986005204 cites W1595488502 @default.
• W1986005204 cites W1599697554 @default.
• W1986005204 cites W1657319669 @default.
• W1986005204 cites W1662568066 @default.
• W1986005204 cites W1781739352 @default.
• W1986005204 cites W1828808016 @default.
• W1986005204 cites W1838195772 @default.
• W1986005204 cites W1900214380 @default.
• W1986005204 cites W190593492 @default.
• W1986005204 cites W1906701964 @default.
• W1986005204 cites W1908649386 @default.
• W1986005204 cites W1922795029 @default.
• W1986005204 cites W1925028832 @default.
• W1986005204 cites W1948530997 @default.
• W1986005204 cites W1964786677 @default.
• W1986005204 cites W1968111694 @default.
• W1986005204 cites W1968395750 @default.
• W1986005204 cites W1970017813 @default.
• W1986005204 cites W1970775019 @default.
• W1986005204 cites W1971389550 @default.
• W1986005204 cites W1974114737 @default.
• W1986005204 cites W1974429500 @default.
• W1986005204 cites W1975518422 @default.
• W1986005204 cites W1979296955 @default.
• W1986005204 cites W1981152506 @default.
• W1986005204 cites W1983042737 @default.
• W1986005204 cites W1983399487 @default.
• W1986005204 cites W1983705519 @default.
• W1986005204 cites W1986208323 @default.
• W1986005204 cites W1988791781 @default.
• W1986005204 cites W1990040067 @default.
• W1986005204 cites W1991027913 @default.
• W1986005204 cites W1992835107 @default.
• W1986005204 cites W1993454917 @default.
• W1986005204 cites W1994888196 @default.
• W1986005204 cites W1995532307 @default.
• W1986005204 cites W1995660211 @default.
• W1986005204 cites W1997060445 @default.
• W1986005204 cites W1999546336 @default.
• W1986005204 cites W1999672910 @default.
• W1986005204 cites W2004303107 @default.
• W1986005204 cites W2005006373 @default.
• W1986005204 cites W2005767586 @default.
• W1986005204 cites W2006207612 @default.
• W1986005204 cites W2008495948 @default.
• W1986005204 cites W2013772013 @default.
• W1986005204 cites W2013855961 @default.
• W1986005204 cites W2014467313 @default.
• W1986005204 cites W2015156245 @default.
• W1986005204 cites W2017070390 @default.
• W1986005204 cites W2020280962 @default.
• W1986005204 cites W2020372432 @default.
• W1986005204 cites W2021071650 @default.
• W1986005204 cites W2021106563 @default.
• W1986005204 cites W2022165665 @default.
• W1986005204 cites W2022177279 @default.
• W1986005204 cites W2025296308 @default.
• W1986005204 cites W2025584833 @default.
• W1986005204 cites W2026482135 @default.
• W1986005204 cites W2029793144 @default.
• W1986005204 cites W2031298245 @default.
• W1986005204 cites W2032336992 @default.
• W1986005204 cites W2033007748 @default.
• W1986005204 cites W2033179355 @default.
• W1986005204 cites W2034129863 @default.
• W1986005204 cites W2034238424 @default.
• W1986005204 cites W2035644598 @default.
• W1986005204 cites W2036017919 @default.
• W1986005204 cites W2036127596 @default.
• W1986005204 cites W2036447451 @default.
• W1986005204 cites W2039568609 @default.
• W1986005204 cites W2042272126 @default.

• next