FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986010440> ?p ?o ?g. }

• W1986010440 abstract "Abstract Mitochondrial biogenesis requires translocation of numerous preproteins across both outer and inner membranes into the matrix of the organelle. This translocation process requires a membrane potential (ΔΨ) and ATP. We have recently demonstrated that the efficient import of a urea-denatured preprotein into the matrix requires GTP hydrolysis (Sepuri, N. B. V., Schulke, N., and Pain, D. (1998) J. Biol. Chem. 273, 1420–1424). We now demonstrate that GTP is generally required for efficient import of various preproteins, both native and urea-denatured. The GTP participation is localized to a particular stage in the protein import process. In the presence of ΔΨ but no added nucleoside triphosphates, the transmembrane movement of preproteins proceeds only to a point early in their translocation across the inner membrane. The completion of translocation into the matrix is independent of ΔΨ but is dependent on a GTP-mediated “push.” This push is likely mediated by a membrane-bound GTPase on the cis side of the inner membrane. This conclusion is based on two observations: (i) GTP does not readily cross the inner membrane barrier and hence, primarily acts outside the inner membrane to stimulate import, and (ii) the GTP-dependent stage of import does not require soluble constituents of the intermembrane space and can be observed in isolated mitoplasts. Efficient import into the matrix, however, is achieved only through the coordinated action of a cisGTP-dependent push and a transATP-dependent “pull.”" @default.
• W1986010440 created "2016-06-24" @default.
• W1986010440 creator A5054494483 @default.
• W1986010440 creator A5062627219 @default.
• W1986010440 creator A5084392934 @default.
• W1986010440 date "1998-08-01" @default.
• W1986010440 modified "2023-10-11" @default.
• W1986010440 title "A GTP-dependent “Push” Is Generally Required for Efficient Protein Translocation across the Mitochondrial Inner Membrane into the Matrix" @default.
• W1986010440 cites W1504997501 @default.
• W1986010440 cites W1507060386 @default.
• W1986010440 cites W1555993362 @default.
• W1986010440 cites W1580182982 @default.
• W1986010440 cites W1600361302 @default.
• W1986010440 cites W1694661515 @default.
• W1986010440 cites W1717988203 @default.
• W1986010440 cites W1764768847 @default.
• W1986010440 cites W1974660961 @default.
• W1986010440 cites W1976372049 @default.
• W1986010440 cites W1976751700 @default.
• W1986010440 cites W1983643913 @default.
• W1986010440 cites W1983790844 @default.
• W1986010440 cites W1984854510 @default.
• W1986010440 cites W1988796765 @default.
• W1986010440 cites W1991513155 @default.
• W1986010440 cites W1992271142 @default.
• W1986010440 cites W1999091451 @default.
• W1986010440 cites W2007676729 @default.
• W1986010440 cites W2010097090 @default.
• W1986010440 cites W2036893511 @default.
• W1986010440 cites W2037464535 @default.
• W1986010440 cites W2039183968 @default.
• W1986010440 cites W2047612546 @default.
• W1986010440 cites W2051141018 @default.
• W1986010440 cites W2051338661 @default.
• W1986010440 cites W2052563180 @default.
• W1986010440 cites W2052768175 @default.
• W1986010440 cites W2062775685 @default.
• W1986010440 cites W2072126849 @default.
• W1986010440 cites W2073698596 @default.
• W1986010440 cites W2081583826 @default.
• W1986010440 cites W2084520521 @default.
• W1986010440 cites W2092453365 @default.
• W1986010440 cites W2095296119 @default.
• W1986010440 cites W2099616208 @default.
• W1986010440 cites W2102355342 @default.
• W1986010440 cites W2115127532 @default.
• W1986010440 cites W2121142142 @default.
• W1986010440 cites W2124782124 @default.
• W1986010440 cites W2130961523 @default.
• W1986010440 cites W2140998993 @default.
• W1986010440 cites W2152214802 @default.
• W1986010440 cites W2160736797 @default.
• W1986010440 cites W2162937818 @default.
• W1986010440 cites W2168763081 @default.
• W1986010440 cites W4256285583 @default.
• W1986010440 cites W63436471 @default.
• W1986010440 cites W2615749116 @default.
• W1986010440 doi "https://doi.org/10.1074/jbc.273.33.20941" @default.
• W1986010440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9694843" @default.
• W1986010440 hasPublicationYear "1998" @default.
• W1986010440 type Work @default.
• W1986010440 sameAs 1986010440 @default.
• W1986010440 citedByCount "28" @default.
• W1986010440 countsByYear W19860104402012 @default.
• W1986010440 countsByYear W19860104402013 @default.
• W1986010440 countsByYear W19860104402017 @default.
• W1986010440 countsByYear W19860104402018 @default.
• W1986010440 crossrefType "journal-article" @default.
• W1986010440 hasAuthorship W1986010440A5054494483 @default.
• W1986010440 hasAuthorship W1986010440A5062627219 @default.
• W1986010440 hasAuthorship W1986010440A5084392934 @default.
• W1986010440 hasBestOaLocation W19860104401 @default.
• W1986010440 hasConcept C104317684 @default.
• W1986010440 hasConcept C118716 @default.
• W1986010440 hasConcept C12554922 @default.
• W1986010440 hasConcept C146587185 @default.
• W1986010440 hasConcept C181199279 @default.
• W1986010440 hasConcept C185592680 @default.
• W1986010440 hasConcept C186850619 @default.
• W1986010440 hasConcept C207332259 @default.
• W1986010440 hasConcept C2776638253 @default.
• W1986010440 hasConcept C41625074 @default.
• W1986010440 hasConcept C547475151 @default.
• W1986010440 hasConcept C55493867 @default.
• W1986010440 hasConcept C65871279 @default.
• W1986010440 hasConcept C86803240 @default.
• W1986010440 hasConcept C95444343 @default.
• W1986010440 hasConceptScore W1986010440C104317684 @default.
• W1986010440 hasConceptScore W1986010440C118716 @default.
• W1986010440 hasConceptScore W1986010440C12554922 @default.
• W1986010440 hasConceptScore W1986010440C146587185 @default.
• W1986010440 hasConceptScore W1986010440C181199279 @default.
• W1986010440 hasConceptScore W1986010440C185592680 @default.
• W1986010440 hasConceptScore W1986010440C186850619 @default.
• W1986010440 hasConceptScore W1986010440C207332259 @default.
• W1986010440 hasConceptScore W1986010440C2776638253 @default.
• W1986010440 hasConceptScore W1986010440C41625074 @default.
• W1986010440 hasConceptScore W1986010440C547475151 @default.
• W1986010440 hasConceptScore W1986010440C55493867 @default.
• W1986010440 hasConceptScore W1986010440C65871279 @default.

• next