Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986010717> ?p ?o ?g. }
- W1986010717 endingPage "2412" @default.
- W1986010717 startingPage "2406" @default.
- W1986010717 abstract "Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand, foot and mouth disease (HFMD), which is an infectious disease frequently occurring in children. A bivalent vaccine against both EV71 and CA16 is highly desirable. In the present study, we compare monovalent inactivated EV71, monovalent inactivated CA16, and a combination vaccine candidate comprising of both inactivated EV71 and CA16, for their immunogenicity and in vivo protective efficacy. The two monovalent vaccines were found to elicit serum antibodies that potently neutralized the homologous virus but had no or weak neutralization activity against the heterologous one; in contrast, the bivalent vaccine immunized sera efficiently neutralized both EV71 and CA16. More importantly, passive immunization with the bivalent vaccine protected mice against either EV71 or CA16 lethal infections, whereas the monovalent vaccines only prevented the homologous but not the heterologous challenges. Together, our results demonstrate that the experimental bivalent vaccine comprising of inactivated EV71 and CA16 induces a balanced protective immunity against both EV71 and CA16, and thus provide proof-of-concept for further development of multivalent vaccines for broad protection against HFMD." @default.
- W1986010717 created "2016-06-24" @default.
- W1986010717 creator A5010719742 @default.
- W1986010717 creator A5030544306 @default.
- W1986010717 creator A5040006210 @default.
- W1986010717 creator A5049211921 @default.
- W1986010717 creator A5077274385 @default.
- W1986010717 date "2014-05-01" @default.
- W1986010717 modified "2023-10-01" @default.
- W1986010717 title "A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses" @default.
- W1986010717 cites W1822185265 @default.
- W1986010717 cites W1867765096 @default.
- W1986010717 cites W1966278779 @default.
- W1986010717 cites W1968895408 @default.
- W1986010717 cites W1983853539 @default.
- W1986010717 cites W1984747082 @default.
- W1986010717 cites W1985429135 @default.
- W1986010717 cites W2002407205 @default.
- W1986010717 cites W2002414632 @default.
- W1986010717 cites W2005618885 @default.
- W1986010717 cites W2011900376 @default.
- W1986010717 cites W2017528901 @default.
- W1986010717 cites W2039707046 @default.
- W1986010717 cites W204088460 @default.
- W1986010717 cites W2052808697 @default.
- W1986010717 cites W2056895449 @default.
- W1986010717 cites W2058325021 @default.
- W1986010717 cites W2059304295 @default.
- W1986010717 cites W2060210640 @default.
- W1986010717 cites W2066717721 @default.
- W1986010717 cites W2072881891 @default.
- W1986010717 cites W2081421695 @default.
- W1986010717 cites W2093177219 @default.
- W1986010717 cites W2096586279 @default.
- W1986010717 cites W2099315132 @default.
- W1986010717 cites W2113315077 @default.
- W1986010717 cites W2113732657 @default.
- W1986010717 cites W2121368175 @default.
- W1986010717 cites W2124116793 @default.
- W1986010717 cites W2125633274 @default.
- W1986010717 cites W2131801122 @default.
- W1986010717 cites W2139833169 @default.
- W1986010717 cites W2140436741 @default.
- W1986010717 cites W2140931158 @default.
- W1986010717 cites W2153545807 @default.
- W1986010717 cites W2153819224 @default.
- W1986010717 cites W2158204033 @default.
- W1986010717 cites W2159398565 @default.
- W1986010717 cites W2165200955 @default.
- W1986010717 cites W2167825211 @default.
- W1986010717 cites W2314964906 @default.
- W1986010717 cites W2319043691 @default.
- W1986010717 cites W2749102845 @default.
- W1986010717 doi "https://doi.org/10.1016/j.vaccine.2014.03.012" @default.
- W1986010717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24657161" @default.
- W1986010717 hasPublicationYear "2014" @default.
- W1986010717 type Work @default.
- W1986010717 sameAs 1986010717 @default.
- W1986010717 citedByCount "64" @default.
- W1986010717 countsByYear W19860107172014 @default.
- W1986010717 countsByYear W19860107172015 @default.
- W1986010717 countsByYear W19860107172016 @default.
- W1986010717 countsByYear W19860107172017 @default.
- W1986010717 countsByYear W19860107172018 @default.
- W1986010717 countsByYear W19860107172019 @default.
- W1986010717 countsByYear W19860107172020 @default.
- W1986010717 countsByYear W19860107172021 @default.
- W1986010717 countsByYear W19860107172022 @default.
- W1986010717 countsByYear W19860107172023 @default.
- W1986010717 crossrefType "journal-article" @default.
- W1986010717 hasAuthorship W1986010717A5010719742 @default.
- W1986010717 hasAuthorship W1986010717A5030544306 @default.
- W1986010717 hasAuthorship W1986010717A5040006210 @default.
- W1986010717 hasAuthorship W1986010717A5049211921 @default.
- W1986010717 hasAuthorship W1986010717A5077274385 @default.
- W1986010717 hasConcept C104317684 @default.
- W1986010717 hasConcept C14086860 @default.
- W1986010717 hasConcept C159047783 @default.
- W1986010717 hasConcept C159654299 @default.
- W1986010717 hasConcept C178790620 @default.
- W1986010717 hasConcept C185592680 @default.
- W1986010717 hasConcept C203014093 @default.
- W1986010717 hasConcept C2522874641 @default.
- W1986010717 hasConcept C2776620830 @default.
- W1986010717 hasConcept C2776872762 @default.
- W1986010717 hasConcept C2777888124 @default.
- W1986010717 hasConcept C2778889330 @default.
- W1986010717 hasConcept C2779341262 @default.
- W1986010717 hasConcept C2780115692 @default.
- W1986010717 hasConcept C2780868878 @default.
- W1986010717 hasConcept C544153396 @default.
- W1986010717 hasConcept C55493867 @default.
- W1986010717 hasConcept C86803240 @default.
- W1986010717 hasConcept C8891405 @default.
- W1986010717 hasConcept C89423630 @default.
- W1986010717 hasConceptScore W1986010717C104317684 @default.
- W1986010717 hasConceptScore W1986010717C14086860 @default.
- W1986010717 hasConceptScore W1986010717C159047783 @default.