Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986011488> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1986011488 endingPage "159" @default.
- W1986011488 startingPage "156" @default.
- W1986011488 abstract "Most hospitals lack a sufficient supply of atropine to treat, simultaneously, patients poisoned with multiple organophosphorous compound (OC) or nerve agent. The presence of a ubiquitous alternate antidote would prove useful if mass poisoning occurred. Our objective was to evaluate the effect of ophthalmic homatropine (Isopto Homatropine 5%) on survivability in a rat model of significant, acute OC poisoning.Sprague-Dawley rats were randomized to one of five pre-treatment groups (N = 10 per group). Prior to experimentation, animals were pre-treated with intramuscular (IM) injections of either atropine 5 mg/kg, atropine 10 mg/kg, homatropine 10 mg/kg, or homatropine 20 mg/kg. The control group received 0.3 mL normal saline IM. Five minutes later, 25 mg/kg of dichlorvos was subcutaneously administered. Mortality rates were compared using Fisher's Exact test. Kaplan-Meier survival curves with Logrank analysis was also performed. If alive at 120 minutes, survival was assumed, and the study was terminated.All rats pre-treated with normal saline, atropine 5 mg/kg, and homatropine 10 mg/kg died. Survival in the homatropine (20 mg/kg) and atropine (10 mg/kg) groups was 30% and 40% respectively. Times to death ranged between 4 and 12 minutes. Overall comparison of time to death revealed a statistically significant improvement for groups pre-treated with homatropine (20 mg/kg) and atropine (10 mg/kg).Pre-treatment with homatropine (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning." @default.
- W1986011488 created "2016-06-24" @default.
- W1986011488 creator A5014478627 @default.
- W1986011488 creator A5022405256 @default.
- W1986011488 creator A5051154027 @default.
- W1986011488 creator A5082300628 @default.
- W1986011488 creator A5082803762 @default.
- W1986011488 date "2006-12-01" @default.
- W1986011488 modified "2023-09-26" @default.
- W1986011488 title "Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning" @default.
- W1986011488 cites W1982626773 @default.
- W1986011488 cites W1992453262 @default.
- W1986011488 cites W1998246454 @default.
- W1986011488 cites W2002850189 @default.
- W1986011488 cites W2081747120 @default.
- W1986011488 cites W2090676184 @default.
- W1986011488 cites W2151758963 @default.
- W1986011488 cites W2409457354 @default.
- W1986011488 cites W4236136472 @default.
- W1986011488 cites W4237177873 @default.
- W1986011488 cites W4244831332 @default.
- W1986011488 cites W90131292 @default.
- W1986011488 doi "https://doi.org/10.1007/bf03161184" @default.
- W1986011488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3550072" @default.
- W1986011488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18072136" @default.
- W1986011488 hasPublicationYear "2006" @default.
- W1986011488 type Work @default.
- W1986011488 sameAs 1986011488 @default.
- W1986011488 citedByCount "6" @default.
- W1986011488 countsByYear W19860114882015 @default.
- W1986011488 countsByYear W19860114882022 @default.
- W1986011488 crossrefType "journal-article" @default.
- W1986011488 hasAuthorship W1986011488A5014478627 @default.
- W1986011488 hasAuthorship W1986011488A5022405256 @default.
- W1986011488 hasAuthorship W1986011488A5051154027 @default.
- W1986011488 hasAuthorship W1986011488A5082300628 @default.
- W1986011488 hasAuthorship W1986011488A5082803762 @default.
- W1986011488 hasBestOaLocation W19860114881 @default.
- W1986011488 hasConcept C126322002 @default.
- W1986011488 hasConcept C161176658 @default.
- W1986011488 hasConcept C170493617 @default.
- W1986011488 hasConcept C2775859210 @default.
- W1986011488 hasConcept C2776291473 @default.
- W1986011488 hasConcept C2777397205 @default.
- W1986011488 hasConcept C2778359560 @default.
- W1986011488 hasConcept C2779365888 @default.
- W1986011488 hasConcept C29730261 @default.
- W1986011488 hasConcept C33070731 @default.
- W1986011488 hasConcept C33789571 @default.
- W1986011488 hasConcept C42219234 @default.
- W1986011488 hasConcept C6557445 @default.
- W1986011488 hasConcept C71924100 @default.
- W1986011488 hasConcept C86803240 @default.
- W1986011488 hasConceptScore W1986011488C126322002 @default.
- W1986011488 hasConceptScore W1986011488C161176658 @default.
- W1986011488 hasConceptScore W1986011488C170493617 @default.
- W1986011488 hasConceptScore W1986011488C2775859210 @default.
- W1986011488 hasConceptScore W1986011488C2776291473 @default.
- W1986011488 hasConceptScore W1986011488C2777397205 @default.
- W1986011488 hasConceptScore W1986011488C2778359560 @default.
- W1986011488 hasConceptScore W1986011488C2779365888 @default.
- W1986011488 hasConceptScore W1986011488C29730261 @default.
- W1986011488 hasConceptScore W1986011488C33070731 @default.
- W1986011488 hasConceptScore W1986011488C33789571 @default.
- W1986011488 hasConceptScore W1986011488C42219234 @default.
- W1986011488 hasConceptScore W1986011488C6557445 @default.
- W1986011488 hasConceptScore W1986011488C71924100 @default.
- W1986011488 hasConceptScore W1986011488C86803240 @default.
- W1986011488 hasIssue "4" @default.
- W1986011488 hasLocation W19860114881 @default.
- W1986011488 hasLocation W19860114882 @default.
- W1986011488 hasLocation W19860114883 @default.
- W1986011488 hasLocation W19860114884 @default.
- W1986011488 hasOpenAccess W1986011488 @default.
- W1986011488 hasPrimaryLocation W19860114881 @default.
- W1986011488 hasRelatedWork W1549900574 @default.
- W1986011488 hasRelatedWork W1986011488 @default.
- W1986011488 hasRelatedWork W1996329178 @default.
- W1986011488 hasRelatedWork W2029121752 @default.
- W1986011488 hasRelatedWork W2088508668 @default.
- W1986011488 hasRelatedWork W2360703646 @default.
- W1986011488 hasRelatedWork W2616159201 @default.
- W1986011488 hasRelatedWork W3126476404 @default.
- W1986011488 hasRelatedWork W3129081089 @default.
- W1986011488 hasRelatedWork W2404133485 @default.
- W1986011488 hasVolume "2" @default.
- W1986011488 isParatext "false" @default.
- W1986011488 isRetracted "false" @default.
- W1986011488 magId "1986011488" @default.
- W1986011488 workType "article" @default.