FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986013003> ?p ?o ?g. }

• W1986013003 endingPage "2222" @default.
• W1986013003 startingPage "2219" @default.
• W1986013003 abstract "T helper 1 (TH1) cells mediate cellular immunity, whereas TH2 cells potentiate antiparasite and humoral immunity. We used a complementary DNA subtraction method, representational display analysis, to show that the small guanosine triphosphatase Rac2 is expressed selectively in murine TH1 cells. Rac induces the interferon-gamma (IFN-gamma) promoter through cooperative activation of the nuclear factor kappa B and p38 mitogen-activated protein kinase pathways. Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-gamma production. Dominant-negative Rac inhibited IFN-gamma production in murine T cells. Moreover, T cells from Rac2-/- mice showed decreased IFN-gamma production under TH1 conditions in vitro. Thus, Rac2 activates TH1-specific signaling and IFN-gamma gene expression." @default.
• W1986013003 created "2016-06-24" @default.
• W1986013003 creator A5004962774 @default.
• W1986013003 creator A5013890373 @default.
• W1986013003 creator A5028742170 @default.
• W1986013003 creator A5033407869 @default.
• W1986013003 creator A5034667645 @default.
• W1986013003 creator A5044844412 @default.
• W1986013003 creator A5047999884 @default.
• W1986013003 creator A5056346259 @default.
• W1986013003 creator A5064443404 @default.
• W1986013003 creator A5074582238 @default.
• W1986013003 date "2000-06-23" @default.
• W1986013003 modified "2023-09-26" @default.
• W1986013003 title "Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation" @default.
• W1986013003 cites W1811517392 @default.
• W1986013003 cites W2002649342 @default.
• W1986013003 cites W2004143904 @default.
• W1986013003 cites W2005275397 @default.
• W1986013003 cites W2010630254 @default.
• W1986013003 cites W2024301675 @default.
• W1986013003 cites W2024367381 @default.
• W1986013003 cites W2027590165 @default.
• W1986013003 cites W2027699993 @default.
• W1986013003 cites W2029836713 @default.
• W1986013003 cites W2042584344 @default.
• W1986013003 cites W2053560001 @default.
• W1986013003 cites W2054363543 @default.
• W1986013003 cites W2055181868 @default.
• W1986013003 cites W2072291835 @default.
• W1986013003 cites W2125504851 @default.
• W1986013003 cites W2147678437 @default.
• W1986013003 cites W2168091755 @default.
• W1986013003 cites W2169554941 @default.
• W1986013003 cites W2406069463 @default.
• W1986013003 doi "https://doi.org/10.1126/science.288.5474.2219" @default.
• W1986013003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10864872" @default.
• W1986013003 hasPublicationYear "2000" @default.
• W1986013003 type Work @default.
• W1986013003 sameAs 1986013003 @default.
• W1986013003 citedByCount "161" @default.
• W1986013003 countsByYear W19860130032012 @default.
• W1986013003 countsByYear W19860130032013 @default.
• W1986013003 countsByYear W19860130032014 @default.
• W1986013003 countsByYear W19860130032015 @default.
• W1986013003 countsByYear W19860130032016 @default.
• W1986013003 countsByYear W19860130032017 @default.
• W1986013003 countsByYear W19860130032019 @default.
• W1986013003 countsByYear W19860130032020 @default.
• W1986013003 countsByYear W19860130032021 @default.
• W1986013003 countsByYear W19860130032022 @default.
• W1986013003 countsByYear W19860130032023 @default.
• W1986013003 crossrefType "journal-article" @default.
• W1986013003 hasAuthorship W1986013003A5004962774 @default.
• W1986013003 hasAuthorship W1986013003A5013890373 @default.
• W1986013003 hasAuthorship W1986013003A5028742170 @default.
• W1986013003 hasAuthorship W1986013003A5033407869 @default.
• W1986013003 hasAuthorship W1986013003A5034667645 @default.
• W1986013003 hasAuthorship W1986013003A5044844412 @default.
• W1986013003 hasAuthorship W1986013003A5047999884 @default.
• W1986013003 hasAuthorship W1986013003A5056346259 @default.
• W1986013003 hasAuthorship W1986013003A5064443404 @default.
• W1986013003 hasAuthorship W1986013003A5074582238 @default.
• W1986013003 hasConcept C102230213 @default.
• W1986013003 hasConcept C104317684 @default.
• W1986013003 hasConcept C153911025 @default.
• W1986013003 hasConcept C202751555 @default.
• W1986013003 hasConcept C2777995097 @default.
• W1986013003 hasConcept C2780841837 @default.
• W1986013003 hasConcept C55493867 @default.
• W1986013003 hasConcept C86803240 @default.
• W1986013003 hasConcept C95444343 @default.
• W1986013003 hasConceptScore W1986013003C102230213 @default.
• W1986013003 hasConceptScore W1986013003C104317684 @default.
• W1986013003 hasConceptScore W1986013003C153911025 @default.
• W1986013003 hasConceptScore W1986013003C202751555 @default.
• W1986013003 hasConceptScore W1986013003C2777995097 @default.
• W1986013003 hasConceptScore W1986013003C2780841837 @default.
• W1986013003 hasConceptScore W1986013003C55493867 @default.
• W1986013003 hasConceptScore W1986013003C86803240 @default.
• W1986013003 hasConceptScore W1986013003C95444343 @default.
• W1986013003 hasIssue "5474" @default.
• W1986013003 hasLocation W19860130031 @default.
• W1986013003 hasLocation W19860130032 @default.
• W1986013003 hasOpenAccess W1986013003 @default.
• W1986013003 hasPrimaryLocation W19860130031 @default.
• W1986013003 hasRelatedWork W1504217544 @default.
• W1986013003 hasRelatedWork W1993612910 @default.
• W1986013003 hasRelatedWork W2019358971 @default.
• W1986013003 hasRelatedWork W2028166249 @default.
• W1986013003 hasRelatedWork W2031928526 @default.
• W1986013003 hasRelatedWork W2088812432 @default.
• W1986013003 hasRelatedWork W2091520566 @default.
• W1986013003 hasRelatedWork W2115549177 @default.
• W1986013003 hasRelatedWork W2301528085 @default.
• W1986013003 hasRelatedWork W4229666144 @default.
• W1986013003 hasVolume "288" @default.
• W1986013003 isParatext "false" @default.

• next