Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986031599> ?p ?o ?g. }
- W1986031599 endingPage "444" @default.
- W1986031599 startingPage "423" @default.
- W1986031599 abstract "The effects of (±)3,4-methylenedioxyamphetamine (MDA) were studied in an identifiable RP4 neuron of the African snail, Achatina fulica Ferussac, using the two-electrode voltage-clamp method. The RP4 neuron generated spontaneous action potentials. Extracellular or intracellular application of MDA elicited action potential bursts of the central RP4 neuron. The action potential bursts elicited by MDA were not blocked when neurons were immersed in high-Mg2+ solution, Ca2+-free solution, nor after continuous perfusion with atropine, d-tubocurarine, propranolol, prazosin, haloperidol, sulpiride or methiothepin. Notably, the induction of action potential bursts was blocked by pretreatment with protein kinase C (PKC) inhibitors, chelerythrine and Ro 31-8220, but not by protein kinase A (PKA) inhibitors, KT-5720 and H89, nor by the phospholipase C (PLC) inhibitor, U73122. PKC activators, i.e., phorbol 12,13-dibutyrate (PDBu) and 1-oleoyl-2-acety-sn-glycerol (OAG; a membrane-permeant DAG analog), facilitate the induction of action potential bursts elicited by MDA. Voltage-clamp studies revealed that MDA decreased the delayed rectifying K+ current (IKD) of the RP4 neuron. Further, although Ro 31-8220 did not affect the IKD, Ro 31-8220 decreased the inhibitory effect of MDA on the IKD. These results suggest that the generation of action potential bursts elicited by MDA was not due to (1) the synaptic effects of neurotransmitters, (2) the cholinergic, adrenergic, dopaminergic or serotoninergic receptors of the excitable membrane. Instead, the MDA-elicited action potential bursts are closely related to PKC activity and the inhibitory effects on the IKD." @default.
- W1986031599 created "2016-06-24" @default.
- W1986031599 creator A5004465181 @default.
- W1986031599 creator A5058062993 @default.
- W1986031599 date "2007-02-01" @default.
- W1986031599 modified "2023-09-26" @default.
- W1986031599 title "(±)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron" @default.
- W1986031599 cites W1479662652 @default.
- W1986031599 cites W1481438484 @default.
- W1986031599 cites W1508152421 @default.
- W1986031599 cites W1514607936 @default.
- W1986031599 cites W1521493025 @default.
- W1986031599 cites W1551893941 @default.
- W1986031599 cites W1594825631 @default.
- W1986031599 cites W1620702917 @default.
- W1986031599 cites W1633868817 @default.
- W1986031599 cites W1786056430 @default.
- W1986031599 cites W1842747747 @default.
- W1986031599 cites W1859823396 @default.
- W1986031599 cites W1897650717 @default.
- W1986031599 cites W1905475555 @default.
- W1986031599 cites W1923547763 @default.
- W1986031599 cites W1964607636 @default.
- W1986031599 cites W1967086564 @default.
- W1986031599 cites W1968022843 @default.
- W1986031599 cites W1968949511 @default.
- W1986031599 cites W1968958292 @default.
- W1986031599 cites W1970677035 @default.
- W1986031599 cites W1973806884 @default.
- W1986031599 cites W1973830611 @default.
- W1986031599 cites W1975309904 @default.
- W1986031599 cites W1975836614 @default.
- W1986031599 cites W1979968248 @default.
- W1986031599 cites W1982332387 @default.
- W1986031599 cites W1985340505 @default.
- W1986031599 cites W1985854802 @default.
- W1986031599 cites W1987238410 @default.
- W1986031599 cites W1988890461 @default.
- W1986031599 cites W1990508321 @default.
- W1986031599 cites W1994464294 @default.
- W1986031599 cites W1997210023 @default.
- W1986031599 cites W1999164562 @default.
- W1986031599 cites W2000025977 @default.
- W1986031599 cites W2001692359 @default.
- W1986031599 cites W2001741412 @default.
- W1986031599 cites W2005523295 @default.
- W1986031599 cites W2005822178 @default.
- W1986031599 cites W2006492267 @default.
- W1986031599 cites W2010842619 @default.
- W1986031599 cites W2011276374 @default.
- W1986031599 cites W2012051875 @default.
- W1986031599 cites W2015297700 @default.
- W1986031599 cites W2015611414 @default.
- W1986031599 cites W2016348467 @default.
- W1986031599 cites W2018166337 @default.
- W1986031599 cites W2021922047 @default.
- W1986031599 cites W2022892553 @default.
- W1986031599 cites W2026451284 @default.
- W1986031599 cites W2030115142 @default.
- W1986031599 cites W2030180059 @default.
- W1986031599 cites W2031266264 @default.
- W1986031599 cites W2033387624 @default.
- W1986031599 cites W2035977654 @default.
- W1986031599 cites W2036107957 @default.
- W1986031599 cites W2039932591 @default.
- W1986031599 cites W2041478806 @default.
- W1986031599 cites W2042201688 @default.
- W1986031599 cites W2042247717 @default.
- W1986031599 cites W2042408259 @default.
- W1986031599 cites W2042500676 @default.
- W1986031599 cites W2043591624 @default.
- W1986031599 cites W2043819440 @default.
- W1986031599 cites W2048077791 @default.
- W1986031599 cites W2050983774 @default.
- W1986031599 cites W2054713470 @default.
- W1986031599 cites W2054747754 @default.
- W1986031599 cites W2060422389 @default.
- W1986031599 cites W2061334036 @default.
- W1986031599 cites W2063813931 @default.
- W1986031599 cites W2071026372 @default.
- W1986031599 cites W2071776347 @default.
- W1986031599 cites W2074083906 @default.
- W1986031599 cites W2075613126 @default.
- W1986031599 cites W2077411516 @default.
- W1986031599 cites W2078133735 @default.
- W1986031599 cites W2079379121 @default.
- W1986031599 cites W2079985516 @default.
- W1986031599 cites W2080575278 @default.
- W1986031599 cites W2082865936 @default.
- W1986031599 cites W2084834317 @default.
- W1986031599 cites W2085547973 @default.
- W1986031599 cites W2086524338 @default.
- W1986031599 cites W2086785259 @default.
- W1986031599 cites W2087853871 @default.
- W1986031599 cites W2089475281 @default.
- W1986031599 cites W2090995040 @default.
- W1986031599 cites W2092359857 @default.
- W1986031599 cites W2093897431 @default.