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- W1986032541 abstract "An attempt has been made to determine the mechanism by which glucagon produces degranulation of the acinar cells of the pancreas. By histologic examination, a progressive decrease in zymogen granules was found in sections of pancreas of rats treated with repeated injections of glucagon suspended in corn oil, reaching 75% degranulation at 12 hours, and 90 % at 18 hours. Fasting neither caused degranulation nor prevented degranulation after glucagon injection. Five hours after sc injection of glucagon in alkaline solution, a 33 % degranulation was found, and there was a 32% decrease in amylase concentration in the homogenates of these pancreases. Adrenalectomy, hypophysectomy or atropinization did not alter the degranulation after glucagon injection. In contrast, there was a 19% increase in the zymogen granules of pancreases of cortisone acetate- treated rats compared with the controls. The pancreatic ducts of rabbits were cannulated and the pancreatic juice was collected. No apparent difference was found b..." @default.
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- W1986032541 date "1962-06-01" @default.
- W1986032541 modified "2023-09-27" @default.
- W1986032541 title "Effect of Glucagon on the Acinar Portion of the Pancreas1" @default.
- W1986032541 doi "https://doi.org/10.1210/endo-70-6-867" @default.
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