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- W1986035530 abstract "In order to investigate the interaction between the triplet state T<sub>1</sub> and ground state oxygen <sup>3</sup>O<sub>2</sub> during pulsed excitation photodynamic therapy (PDT), we measured the phosphorescence and singlet oxygen <sup>1</sup>O<sub>2</sub> fluorescence time-resolved waveform. The phosphorescence time-resolved waveform from clinical photosensitizers has not been obtained because this signal was buried in the photosensitizer fluorescence. We constructed the experimental setup with a spectral and temporal filter to select the phosphorescence signals from the Photofrin(II)<sup>(R)</sup> and Talaporfin sodium solution. The lifetimes and spectrums of the measured luminescence coincided with the phosphorescence characteristics, respectively. We obtained the phosphorescence time-resolved waveforms from the clinical photosensitizer solutions successfully. The <sup>1</sup>O<sub>2</sub> fluorescence time-resolved waveforms from these photosensitizers were measured with an IR-PMT with a photon counter. The fluorescence time-resolved waveforms of each photosensitizer were also obtained by the authors. We could consequently describe sequential generation of three time-resolved waveforms throughout the photosensitive reaction in the clinical photosensitizers. We think we may evaluate the photoseisitizer characteristics by these waveforms." @default.
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- W1986035530 date "2007-02-08" @default.
- W1986035530 modified "2023-09-23" @default.
- W1986035530 title "The measurement of the phosphorescence and singlet oxygen fluorescence time-resolved waveforms of Photofrin(II) and Talaporfin sodium with pulsed excitation" @default.
- W1986035530 doi "https://doi.org/10.1117/12.699857" @default.
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