FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986043145> ?p ?o ?g. }

• W1986043145 endingPage "120" @default.
• W1986043145 startingPage "111" @default.
• W1986043145 abstract "The non-steroidal antioestrogens tamoxifen, 4-hydroxytamoxifen, trioxifene, LY 117018 and LY 139481 have widely divergent affinities for oestrogen receptors from rat mammary tumours. The latter two compounds have much reduced partial agonist activity in rat uterus, compared to tamoxifen, but were less effective antitumour agents than tamoxifen. No direct correlation was established between receptor affinity and biological response in rat uterus or rat mammary carcinoma. However, in in vitro studies of growth inhibition of human breast cancer cells (MCF7), the order of potency was the same as the order of relative binding affinity. Differences in in vivo activity of these antioestrogens may be related to biological half-life which is dependent on the dose, route of administration and metabolic stability of the antioestrogens. Growth inhibition in MCF 7 cells did not correlate with affinity for tamoxifen-specific binding sites, nor was there any evidence for differences between antioestrogens in their mechanism of action on the rat uterus. It is concluded that the primary effects of antioestrogens are mediated by binding to oestrogen receptors." @default.
• W1986043145 created "2016-06-24" @default.
• W1986043145 creator A5013878646 @default.
• W1986043145 creator A5027365975 @default.
• W1986043145 creator A5038101661 @default.
• W1986043145 creator A5048188769 @default.
• W1986043145 date "1984-01-01" @default.
• W1986043145 modified "2023-09-25" @default.
• W1986043145 title "Non-steroidal antioestrogens—Receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells" @default.
• W1986043145 cites W1975662389 @default.
• W1986043145 cites W1979477696 @default.
• W1986043145 cites W1996878798 @default.
• W1986043145 cites W1998525632 @default.
• W1986043145 cites W2006812453 @default.
• W1986043145 cites W2016386722 @default.
• W1986043145 cites W2018783795 @default.
• W1986043145 cites W2025422110 @default.
• W1986043145 cites W2029406824 @default.
• W1986043145 cites W2035115059 @default.
• W1986043145 cites W2051676088 @default.
• W1986043145 cites W2074335085 @default.
• W1986043145 cites W2076540339 @default.
• W1986043145 cites W2081571205 @default.
• W1986043145 cites W2082633055 @default.
• W1986043145 cites W2093108428 @default.
• W1986043145 cites W2093646053 @default.
• W1986043145 cites W2127787276 @default.
• W1986043145 cites W2153285273 @default.
• W1986043145 doi "https://doi.org/10.1016/0022-4731(84)90197-3" @default.
• W1986043145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6538611" @default.
• W1986043145 hasPublicationYear "1984" @default.
• W1986043145 type Work @default.
• W1986043145 sameAs 1986043145 @default.
• W1986043145 citedByCount "106" @default.
• W1986043145 countsByYear W19860431452012 @default.
• W1986043145 countsByYear W19860431452014 @default.
• W1986043145 countsByYear W19860431452015 @default.
• W1986043145 countsByYear W19860431452022 @default.
• W1986043145 crossrefType "journal-article" @default.
• W1986043145 hasAuthorship W1986043145A5013878646 @default.
• W1986043145 hasAuthorship W1986043145A5027365975 @default.
• W1986043145 hasAuthorship W1986043145A5038101661 @default.
• W1986043145 hasAuthorship W1986043145A5048188769 @default.
• W1986043145 hasConcept C121608353 @default.
• W1986043145 hasConcept C126322002 @default.
• W1986043145 hasConcept C134018914 @default.
• W1986043145 hasConcept C150903083 @default.
• W1986043145 hasConcept C170493617 @default.
• W1986043145 hasConcept C185592680 @default.
• W1986043145 hasConcept C202751555 @default.
• W1986043145 hasConcept C207001950 @default.
• W1986043145 hasConcept C2776067312 @default.
• W1986043145 hasConcept C2776120743 @default.
• W1986043145 hasConcept C2777176818 @default.
• W1986043145 hasConcept C2777546739 @default.
• W1986043145 hasConcept C2778001805 @default.
• W1986043145 hasConcept C2778938600 @default.
• W1986043145 hasConcept C2779066055 @default.
• W1986043145 hasConcept C2994001847 @default.
• W1986043145 hasConcept C530470458 @default.
• W1986043145 hasConcept C55493867 @default.
• W1986043145 hasConcept C71924100 @default.
• W1986043145 hasConcept C86803240 @default.
• W1986043145 hasConcept C98274493 @default.
• W1986043145 hasConceptScore W1986043145C121608353 @default.
• W1986043145 hasConceptScore W1986043145C126322002 @default.
• W1986043145 hasConceptScore W1986043145C134018914 @default.
• W1986043145 hasConceptScore W1986043145C150903083 @default.
• W1986043145 hasConceptScore W1986043145C170493617 @default.
• W1986043145 hasConceptScore W1986043145C185592680 @default.
• W1986043145 hasConceptScore W1986043145C202751555 @default.
• W1986043145 hasConceptScore W1986043145C207001950 @default.
• W1986043145 hasConceptScore W1986043145C2776067312 @default.
• W1986043145 hasConceptScore W1986043145C2776120743 @default.
• W1986043145 hasConceptScore W1986043145C2777176818 @default.
• W1986043145 hasConceptScore W1986043145C2777546739 @default.
• W1986043145 hasConceptScore W1986043145C2778001805 @default.
• W1986043145 hasConceptScore W1986043145C2778938600 @default.
• W1986043145 hasConceptScore W1986043145C2779066055 @default.
• W1986043145 hasConceptScore W1986043145C2994001847 @default.
• W1986043145 hasConceptScore W1986043145C530470458 @default.
• W1986043145 hasConceptScore W1986043145C55493867 @default.
• W1986043145 hasConceptScore W1986043145C71924100 @default.
• W1986043145 hasConceptScore W1986043145C86803240 @default.
• W1986043145 hasConceptScore W1986043145C98274493 @default.
• W1986043145 hasIssue "1" @default.
• W1986043145 hasLocation W19860431451 @default.
• W1986043145 hasLocation W19860431452 @default.
• W1986043145 hasOpenAccess W1986043145 @default.
• W1986043145 hasPrimaryLocation W19860431451 @default.
• W1986043145 hasRelatedWork W2027913950 @default.
• W1986043145 hasRelatedWork W2034583712 @default.
• W1986043145 hasRelatedWork W2050423574 @default.
• W1986043145 hasRelatedWork W2063619316 @default.
• W1986043145 hasRelatedWork W2074202495 @default.
• W1986043145 hasRelatedWork W2074257588 @default.
• W1986043145 hasRelatedWork W2083766398 @default.
• W1986043145 hasRelatedWork W2411328470 @default.

• next