Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986044360> ?p ?o ?g. }
- W1986044360 endingPage "1873" @default.
- W1986044360 startingPage "1864" @default.
- W1986044360 abstract "The p75 neurotrophin receptor (p75(NTR)) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation and proliferation. To evaluate the influence of p75(NTR) in breast cancer development, we have established and characterized breast cancer cells which stably overexpress p75(NTR). We showed that p75(NTR) overexpression per se promoted cell survival to apoptogens with a concomitant slowdown of cell growth. The pro-survival effect is associated with an increased expression of the inhibitor of apoptosis protein-1 (c-IAP1), a decrease of TRAIL-induced cleavage of PARP, procaspase 9 and procaspase 3, and a decrease of cytochrome C release from the mitochondria. The anti-proliferative effect is due to a cell accumulation in G0/G1, associated with a decrease of Rb phosphorylation and an increase of p21(waf1). Interestingly, inhibition of p21(waf1) with siRNA not only restores proliferation but also abolishes the pro-survival effect of p75(NTR), indicating the key role of p21(waf1) in the biological functions of p75(NTR). Finally, using a SCID mice xenograft model, we showed that p75(NTR) overexpression favors tumor growth and strongly increases tumor resistance to anti-tumoral treatment. Together, our findings suggest that p75(NTR) overexpression in breast tumor cells could favor tumor survival and contribute to tumor resistance to drugs. This provides a rationale to consider p75(NTR) as a potential target for the future design of innovative therapeutic strategies." @default.
- W1986044360 created "2016-06-24" @default.
- W1986044360 creator A5029801587 @default.
- W1986044360 creator A5057886721 @default.
- W1986044360 creator A5058970495 @default.
- W1986044360 creator A5064613683 @default.
- W1986044360 creator A5070012804 @default.
- W1986044360 creator A5091771182 @default.
- W1986044360 date "2010-12-01" @default.
- W1986044360 modified "2023-10-17" @default.
- W1986044360 title "Overexpression of p75NTR increases survival of breast cancer cells through p21waf1" @default.
- W1986044360 cites W1604346393 @default.
- W1986044360 cites W1605269201 @default.
- W1986044360 cites W1966488436 @default.
- W1986044360 cites W1968869996 @default.
- W1986044360 cites W1972305847 @default.
- W1986044360 cites W1974493336 @default.
- W1986044360 cites W1981288686 @default.
- W1986044360 cites W1981860646 @default.
- W1986044360 cites W1982273913 @default.
- W1986044360 cites W1982687515 @default.
- W1986044360 cites W1983130174 @default.
- W1986044360 cites W1989142029 @default.
- W1986044360 cites W1993206451 @default.
- W1986044360 cites W2001844599 @default.
- W1986044360 cites W2012423618 @default.
- W1986044360 cites W2015670731 @default.
- W1986044360 cites W2018038188 @default.
- W1986044360 cites W2027069909 @default.
- W1986044360 cites W2030378354 @default.
- W1986044360 cites W2035296213 @default.
- W1986044360 cites W2035465043 @default.
- W1986044360 cites W2054161575 @default.
- W1986044360 cites W2066577103 @default.
- W1986044360 cites W2073604155 @default.
- W1986044360 cites W2077036618 @default.
- W1986044360 cites W2090402875 @default.
- W1986044360 cites W2090563156 @default.
- W1986044360 cites W2102740981 @default.
- W1986044360 cites W2105278941 @default.
- W1986044360 cites W2108838449 @default.
- W1986044360 cites W2114471642 @default.
- W1986044360 cites W2118477196 @default.
- W1986044360 cites W2123408027 @default.
- W1986044360 cites W2125474652 @default.
- W1986044360 cites W2127433325 @default.
- W1986044360 cites W2141528632 @default.
- W1986044360 cites W2142739240 @default.
- W1986044360 cites W2162262059 @default.
- W1986044360 cites W2162496698 @default.
- W1986044360 cites W2411593190 @default.
- W1986044360 cites W90182880 @default.
- W1986044360 doi "https://doi.org/10.1016/j.cellsig.2010.07.014" @default.
- W1986044360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20667470" @default.
- W1986044360 hasPublicationYear "2010" @default.
- W1986044360 type Work @default.
- W1986044360 sameAs 1986044360 @default.
- W1986044360 citedByCount "55" @default.
- W1986044360 countsByYear W19860443602012 @default.
- W1986044360 countsByYear W19860443602013 @default.
- W1986044360 countsByYear W19860443602014 @default.
- W1986044360 countsByYear W19860443602015 @default.
- W1986044360 countsByYear W19860443602016 @default.
- W1986044360 countsByYear W19860443602017 @default.
- W1986044360 countsByYear W19860443602018 @default.
- W1986044360 countsByYear W19860443602019 @default.
- W1986044360 countsByYear W19860443602020 @default.
- W1986044360 countsByYear W19860443602021 @default.
- W1986044360 countsByYear W19860443602022 @default.
- W1986044360 countsByYear W19860443602023 @default.
- W1986044360 crossrefType "journal-article" @default.
- W1986044360 hasAuthorship W1986044360A5029801587 @default.
- W1986044360 hasAuthorship W1986044360A5057886721 @default.
- W1986044360 hasAuthorship W1986044360A5058970495 @default.
- W1986044360 hasAuthorship W1986044360A5064613683 @default.
- W1986044360 hasAuthorship W1986044360A5070012804 @default.
- W1986044360 hasAuthorship W1986044360A5091771182 @default.
- W1986044360 hasConcept C121608353 @default.
- W1986044360 hasConcept C170493617 @default.
- W1986044360 hasConcept C190283241 @default.
- W1986044360 hasConcept C502942594 @default.
- W1986044360 hasConcept C54355233 @default.
- W1986044360 hasConcept C55493867 @default.
- W1986044360 hasConcept C56703729 @default.
- W1986044360 hasConcept C62112901 @default.
- W1986044360 hasConcept C86803240 @default.
- W1986044360 hasConcept C92020748 @default.
- W1986044360 hasConcept C95444343 @default.
- W1986044360 hasConcept C96232424 @default.
- W1986044360 hasConceptScore W1986044360C121608353 @default.
- W1986044360 hasConceptScore W1986044360C170493617 @default.
- W1986044360 hasConceptScore W1986044360C190283241 @default.
- W1986044360 hasConceptScore W1986044360C502942594 @default.
- W1986044360 hasConceptScore W1986044360C54355233 @default.
- W1986044360 hasConceptScore W1986044360C55493867 @default.
- W1986044360 hasConceptScore W1986044360C56703729 @default.
- W1986044360 hasConceptScore W1986044360C62112901 @default.
- W1986044360 hasConceptScore W1986044360C86803240 @default.