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- W1986044984 abstract "The ribosomal site of action of the antibiotic vernamycin A was studied by investigating the effect of the drug on the non-enzymatic binding of fMet-tRNA. 1. Vernamycin A inhibits the non-enzymatic binding of fMet-tRNA to 70-S ribosomes and to 50-S subunits, and can displace previously bound fMet-tRNA from 70-S ribosomes. 2. Vernamycin A inhibits the binding of fMet-tRNA to a puromycin reactive site (P site), which is not affected by tetracycline. 3. Although vernamycin A inhibits the puromycin reaction in model systems it does not inhibit peptide bond formation occurring on polysomes. Consequently, the antibiotic probably inhibits peptide bond formation in model in vitro systems not by directly inhibiting peptide bond formation, but by inhibiting the binding of the tRNA to the ribosome. 4. The data indicate that the ribosomal binding sites for vernamycin A on the one hand and carbomycin B, chloramphenicol, erythromycin, leucomycin A3, spiramycin III and tylosin on the other hand, are different." @default.
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- W1986044984 date "1972-09-01" @default.
- W1986044984 modified "2023-10-14" @default.
- W1986044984 title "Vernamycin A inhibits the non-enzymatic binding of fMet-tRNA to ribosomes" @default.
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- W1986044984 doi "https://doi.org/10.1016/0005-2787(72)90191-8" @default.
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