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- W1986061765 abstract "The aim of this study was to improve molecular characterisation of adenomyosis and identify potential biomarkers of this pathology. For this purpose, transcriptomes of myometrium containing adenomyosic lesions and endometrium from patients with versus without adenomyosis were investigated. Endometrial and myometrial biopsies were obtained from hysterectomy specimens of patients with (n=21) and without (n=13) adenomyosis. RNAs were extracted and gene expression profiles were investigated using the affymetrix microarrays. The differential gene expression profile was evaluated with bioinformatics. The differential gene expression profiles between endometrial and myometrial samples were investigated in patients with adenomyosis (paired sample analysis) and then, in patients without adenomyosis. The lists of significant genes were cross-intersected to identify of list of genes exclusive to the pathological group. Endometrial biomarkers of adenomyosis were validated by RT-qPCR. In the control group, 3265 genes were differentially expressed with 1580 and 1685 genes up- and down-regulated respectively in endometria compared with myometria. In patients with adenomyosis, this differential was characterized by 2570 genes with 1298 and 1272 genes up- and down-regulated, respectively, in endometria compared with myometria. The cross-intersection of these two lists of genes allowed the identification of 542 genes exclusive to the pathological group with 280 and 262 genes up- and down-regulated in endometrium. Only endometrial genes exclusive to the pathological group and for which there are no significant difference between myometrium from patients with and without adenomyosis were selected for biomarkers of adenomyosis. The top up- and down-regulated genes exclusive to the endometrium from the pathological group were SH2D3A (x32), KLHL31 (x15), ADAMTS16 (x14), FOXP2 (x-31), F2RL2 (x-29), DGKB (-14) and play roles in several functions including migration and extracellular remodeling. These results could contribute for improving our understanding of the physiopathology of adenomyosis and should open new perspectives in the diagnosis of this pathology." @default.
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- W1986061765 date "2014-09-01" @default.
- W1986061765 modified "2023-09-28" @default.
- W1986061765 title "New biomarkers of adenomyosis in endometrium" @default.
- W1986061765 doi "https://doi.org/10.1016/j.fertnstert.2014.07.172" @default.
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