Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986062299> ?p ?o ?g. }
- W1986062299 endingPage "1084" @default.
- W1986062299 startingPage "1071" @default.
- W1986062299 abstract "Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by CAG/polyglutamine repeat expansions in the ataxin-7 gene. Ataxin-7 is a component of two different transcription coactivator complexes, and recent work indicates that disease protein normal function is altered in polyglutamine neurodegeneration. Given this, we studied how ataxin-7 gene expression is regulated. The ataxin-7 repeat and translation start site are flanked by binding sites for CTCF, a highly conserved multifunctional transcription regulator. When we analyzed this region, we discovered an adjacent alternative promoter and a convergently transcribed antisense noncoding RNA, SCAANT1. To understand how CTCF regulates ataxin-7 gene expression, we introduced ataxin-7 mini-genes into mice, and found that CTCF is required for SCAANT1 expression. Loss of SCAANT1 derepressed ataxin-7 sense transcription in a cis-dependent fashion and was accompanied by chromatin remodeling. Discovery of this pathway underscores the importance of altered epigenetic regulation for disease pathology at repeat loci exhibiting bidirectional transcription." @default.
- W1986062299 created "2016-06-24" @default.
- W1986062299 creator A5008733999 @default.
- W1986062299 creator A5025246273 @default.
- W1986062299 creator A5027551170 @default.
- W1986062299 creator A5037467756 @default.
- W1986062299 creator A5041142138 @default.
- W1986062299 creator A5046955485 @default.
- W1986062299 creator A5050852049 @default.
- W1986062299 creator A5064140449 @default.
- W1986062299 creator A5080777434 @default.
- W1986062299 creator A5084891516 @default.
- W1986062299 date "2011-06-01" @default.
- W1986062299 modified "2023-10-17" @default.
- W1986062299 title "CTCF Regulates Ataxin-7 Expression through Promotion of a Convergently Transcribed, Antisense Noncoding RNA" @default.
- W1986062299 cites W126279518 @default.
- W1986062299 cites W1523020113 @default.
- W1986062299 cites W1686333409 @default.
- W1986062299 cites W1965975446 @default.
- W1986062299 cites W1968190810 @default.
- W1986062299 cites W1972029047 @default.
- W1986062299 cites W1986234964 @default.
- W1986062299 cites W1986461863 @default.
- W1986062299 cites W1993691393 @default.
- W1986062299 cites W1998879017 @default.
- W1986062299 cites W2005506831 @default.
- W1986062299 cites W2007482260 @default.
- W1986062299 cites W2008526580 @default.
- W1986062299 cites W2019855110 @default.
- W1986062299 cites W2021798161 @default.
- W1986062299 cites W2028022357 @default.
- W1986062299 cites W2034131948 @default.
- W1986062299 cites W2037064308 @default.
- W1986062299 cites W2039376206 @default.
- W1986062299 cites W2039408641 @default.
- W1986062299 cites W2047005748 @default.
- W1986062299 cites W2052883021 @default.
- W1986062299 cites W2053187937 @default.
- W1986062299 cites W2058543711 @default.
- W1986062299 cites W2062682951 @default.
- W1986062299 cites W2078526277 @default.
- W1986062299 cites W2083294254 @default.
- W1986062299 cites W2084442305 @default.
- W1986062299 cites W2085209572 @default.
- W1986062299 cites W2092574488 @default.
- W1986062299 cites W2104720318 @default.
- W1986062299 cites W2111714867 @default.
- W1986062299 cites W2112001233 @default.
- W1986062299 cites W2115674719 @default.
- W1986062299 cites W2120448227 @default.
- W1986062299 cites W2127390110 @default.
- W1986062299 cites W2130919037 @default.
- W1986062299 cites W2131173813 @default.
- W1986062299 cites W2136932227 @default.
- W1986062299 cites W2137863765 @default.
- W1986062299 cites W2138001045 @default.
- W1986062299 cites W2144281053 @default.
- W1986062299 cites W2153366638 @default.
- W1986062299 cites W2155792198 @default.
- W1986062299 cites W2159880072 @default.
- W1986062299 cites W2167653615 @default.
- W1986062299 cites W2168889463 @default.
- W1986062299 cites W2325787268 @default.
- W1986062299 cites W2415805387 @default.
- W1986062299 cites W4378744814 @default.
- W1986062299 doi "https://doi.org/10.1016/j.neuron.2011.05.027" @default.
- W1986062299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3139428" @default.
- W1986062299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21689595" @default.
- W1986062299 hasPublicationYear "2011" @default.
- W1986062299 type Work @default.
- W1986062299 sameAs 1986062299 @default.
- W1986062299 citedByCount "117" @default.
- W1986062299 countsByYear W19860622992012 @default.
- W1986062299 countsByYear W19860622992013 @default.
- W1986062299 countsByYear W19860622992014 @default.
- W1986062299 countsByYear W19860622992015 @default.
- W1986062299 countsByYear W19860622992016 @default.
- W1986062299 countsByYear W19860622992017 @default.
- W1986062299 countsByYear W19860622992018 @default.
- W1986062299 countsByYear W19860622992019 @default.
- W1986062299 countsByYear W19860622992020 @default.
- W1986062299 countsByYear W19860622992021 @default.
- W1986062299 countsByYear W19860622992023 @default.
- W1986062299 crossrefType "journal-article" @default.
- W1986062299 hasAuthorship W1986062299A5008733999 @default.
- W1986062299 hasAuthorship W1986062299A5025246273 @default.
- W1986062299 hasAuthorship W1986062299A5027551170 @default.
- W1986062299 hasAuthorship W1986062299A5037467756 @default.
- W1986062299 hasAuthorship W1986062299A5041142138 @default.
- W1986062299 hasAuthorship W1986062299A5046955485 @default.
- W1986062299 hasAuthorship W1986062299A5050852049 @default.
- W1986062299 hasAuthorship W1986062299A5064140449 @default.
- W1986062299 hasAuthorship W1986062299A5080777434 @default.
- W1986062299 hasAuthorship W1986062299A5084891516 @default.
- W1986062299 hasBestOaLocation W19860622991 @default.
- W1986062299 hasConcept C104317684 @default.
- W1986062299 hasConcept C111936080 @default.
- W1986062299 hasConcept C138885662 @default.