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• W1986070118 abstract "Regulation of intracellular calcium ion concentration ([Ca2+]in) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca2+ influx via voltage-gated Ca2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca2+]in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca2+]in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca2+ response but also a quantitative way to regulate the [Ca2+]in dynamics by controlling the external electrical stimulation." @default.
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• W1986070118 date "2013-07-01" @default.
• W1986070118 modified "2023-10-06" @default.
• W1986070118 title "A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation" @default.
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• W1986070118 doi "https://doi.org/10.1016/j.mbs.2013.04.005" @default.
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