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- W1986070145 abstract "Abstract A transcriptional feedback loop is the simplest and most direct means for a transcription factor to provide an increased stability of gene expression. In this work performed in human cells, we reveal a new negative auto-regulatory mechanism involving an alternative transcription start site (TSS) usage. Using the activating transcription factor ZNF143 as a model, we show that the ZNF143 low-affinity binding sites, located downstream of its canonical TSS, play the role of protein sensors to induce the up- or down-regulation of ZNF143 gene expression. We uncovered that the TSS switch that mediates this regulation implies the differential expression of two transcripts with an opposite protein production ability due to their different 5′ untranslated regions. Moreover, our analysis of the ENCODE data suggests that this mechanism could be used by other transcription factors to rapidly respond to their own aberrant expression level." @default.
- W1986070145 created "2016-06-24" @default.
- W1986070145 creator A5049411069 @default.
- W1986070145 creator A5053331151 @default.
- W1986070145 date "2013-11-14" @default.
- W1986070145 modified "2023-09-25" @default.
- W1986070145 title "Transcription factor abundance controlled by an auto-regulatory mechanism involving a transcription start site switch" @default.
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- W1986070145 doi "https://doi.org/10.1093/nar/gkt1136" @default.
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