FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986085718> ?p ?o ?g. }

• W1986085718 endingPage "297" @default.
• W1986085718 startingPage "291" @default.
• W1986085718 abstract "✓ Tumor necrosis factor-α (TNFα) protein and messenger (m)RNA distribution was studied in biopsy samples of glial brain tumors, using immunohistochemistry and in situ hybridization with molecular probes, to investigate the role of this cytokine in tumor proliferation and immunological host defense. Focal expression of TNFα was detected in four of four glioblastomas, one of two anaplastic astrocytomas, and four of five low-grade astrocytomas, regardless of their subtype or grade of malignancy, but in none of the normal peritumoral brain tissues used as controls. The TNFα protein and mRNA were present in reactive astrocytes and protoplasmic tumor cells, confined to areas of leukocyte or T-lymphocyte infiltration, and less pronounced in tumor cells at the edge of necrosis. Additionally, TNFα reactivity was found in infiltrating macrophages and perivascular microglia. Immunohistochemistry and in situ hybridization for TNFα showed comparable reaction patterns and numbers of TNFα-positive cells, even though the sensitivity of in situ hybridization was significantly higher. Quantitative evaluation of TNFα protein, TNFα mRNA, and leukocyte infiltration revealed a significant positive correlation between the TNFα-positive reactive astrocytes and the number of lymphocytes present in corresponding areas. Together, these data lead to the conclusion that TNFα in reactive astrocytes and monocytic cells within tumor areas of high leukocyte infiltration and in tumor cells at the border of necrosis may represent one defense pathway of the immune system against tumor proliferation." @default.
• W1986085718 created "2016-06-24" @default.
• W1986085718 creator A5005622942 @default.
• W1986085718 creator A5006848706 @default.
• W1986085718 creator A5040415302 @default.
• W1986085718 creator A5050861407 @default.
• W1986085718 creator A5051661613 @default.
• W1986085718 creator A5058974915 @default.
• W1986085718 creator A5076252722 @default.
• W1986085718 date "1995-08-01" @default.
• W1986085718 modified "2023-09-25" @default.
• W1986085718 title "Detection of tumor necrosis factor-α protein and messenger RNA in human glial brain tumors: comparison of immunohistochemistry with in situ hybridization using molecular probes" @default.
• W1986085718 cites W1817103017 @default.
• W1986085718 cites W1960667696 @default.
• W1986085718 cites W1966088318 @default.
• W1986085718 cites W1966573542 @default.
• W1986085718 cites W1967499987 @default.
• W1986085718 cites W1973461445 @default.
• W1986085718 cites W1976845082 @default.
• W1986085718 cites W1980562558 @default.
• W1986085718 cites W1981770067 @default.
• W1986085718 cites W1997566717 @default.
• W1986085718 cites W2003647928 @default.
• W1986085718 cites W2016671244 @default.
• W1986085718 cites W2026359714 @default.
• W1986085718 cites W2035089640 @default.
• W1986085718 cites W2048907346 @default.
• W1986085718 cites W2052837799 @default.
• W1986085718 cites W2057123987 @default.
• W1986085718 cites W2061134998 @default.
• W1986085718 cites W2064338748 @default.
• W1986085718 cites W2068384471 @default.
• W1986085718 cites W2069132198 @default.
• W1986085718 cites W2071823056 @default.
• W1986085718 cites W2079544700 @default.
• W1986085718 cites W2080217141 @default.
• W1986085718 cites W2083116993 @default.
• W1986085718 cites W2083726090 @default.
• W1986085718 cites W2083801136 @default.
• W1986085718 cites W2089172549 @default.
• W1986085718 cites W2094202296 @default.
• W1986085718 cites W2098161855 @default.
• W1986085718 cites W2102093684 @default.
• W1986085718 cites W2109227615 @default.
• W1986085718 cites W2122400789 @default.
• W1986085718 cites W2135271960 @default.
• W1986085718 cites W2151535660 @default.
• W1986085718 cites W2154536753 @default.
• W1986085718 cites W2158905125 @default.
• W1986085718 cites W2174322658 @default.
• W1986085718 cites W2312313151 @default.
• W1986085718 cites W35791140 @default.
• W1986085718 doi "https://doi.org/10.3171/jns.1995.83.2.0291" @default.
• W1986085718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7616275" @default.
• W1986085718 hasPublicationYear "1995" @default.
• W1986085718 type Work @default.
• W1986085718 sameAs 1986085718 @default.
• W1986085718 citedByCount "35" @default.
• W1986085718 countsByYear W19860857182012 @default.
• W1986085718 countsByYear W19860857182014 @default.
• W1986085718 countsByYear W19860857182016 @default.
• W1986085718 countsByYear W19860857182018 @default.
• W1986085718 countsByYear W19860857182019 @default.
• W1986085718 countsByYear W19860857182020 @default.
• W1986085718 crossrefType "journal-article" @default.
• W1986085718 hasAuthorship W1986085718A5005622942 @default.
• W1986085718 hasAuthorship W1986085718A5006848706 @default.
• W1986085718 hasAuthorship W1986085718A5040415302 @default.
• W1986085718 hasAuthorship W1986085718A5050861407 @default.
• W1986085718 hasAuthorship W1986085718A5051661613 @default.
• W1986085718 hasAuthorship W1986085718A5058974915 @default.
• W1986085718 hasAuthorship W1986085718A5076252722 @default.
• W1986085718 hasConcept C104317684 @default.
• W1986085718 hasConcept C105580179 @default.
• W1986085718 hasConcept C121332964 @default.
• W1986085718 hasConcept C142724271 @default.
• W1986085718 hasConcept C153400128 @default.
• W1986085718 hasConcept C17991360 @default.
• W1986085718 hasConcept C203014093 @default.
• W1986085718 hasConcept C204232928 @default.
• W1986085718 hasConcept C2776914184 @default.
• W1986085718 hasConcept C2778227246 @default.
• W1986085718 hasConcept C2778690821 @default.
• W1986085718 hasConcept C2779130545 @default.
• W1986085718 hasConcept C2779830541 @default.
• W1986085718 hasConcept C502942594 @default.
• W1986085718 hasConcept C55493867 @default.
• W1986085718 hasConcept C71924100 @default.
• W1986085718 hasConcept C81439078 @default.
• W1986085718 hasConcept C86803240 @default.
• W1986085718 hasConcept C97355855 @default.
• W1986085718 hasConceptScore W1986085718C104317684 @default.
• W1986085718 hasConceptScore W1986085718C105580179 @default.
• W1986085718 hasConceptScore W1986085718C121332964 @default.
• W1986085718 hasConceptScore W1986085718C142724271 @default.
• W1986085718 hasConceptScore W1986085718C153400128 @default.
• W1986085718 hasConceptScore W1986085718C17991360 @default.
• W1986085718 hasConceptScore W1986085718C203014093 @default.

• next