FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986086154> ?p ?o ?g. }

• W1986086154 endingPage "e43236" @default.
• W1986086154 startingPage "e43236" @default.
• W1986086154 abstract "To confirm the clinical significance of NF-κB and JNK protein expression from experimentally identified candidates for predicting prognosis for patients with 5-FU treatment, we evaluated the protein expression of surgically removed specimens. A total of 79 specimens were obtained from 30 gastric and 49 colorectal cancer patients who underwent R0 resection followed by postoperative 5-FU based adjuvant chemotherapy. Immunohistochemical examinations of NF-κB and JNK on tissue microarrays (TMAs) revealed that significantly shorter time-to-relapse (TTR) in both NF-κB(+) and JNK(-) subgroups in both gastric (NF-κB(+), p = 0.0002, HR11.7. 95%CI3 3.2-43.4; JNK(-), p = 0.0302, HR4.4, 95%CI 1.2-16.6) and colon (NF-κB(+), p = 0.0038, HR36.9, 95%CI 3.2-426.0; JNK(-), p = 0.0098, HR3.2, 95%CI 1.3-7.7) cancers. These protein expression patterns also show strong discriminately power in gastric cancer patients for overall survival rate, suggesting a potential utility as prognostic or chemosensitivity markers. Baseline expression of these proteins using gastric cancer cell lines demonstrated the reciprocal patterns between NF-κB and JNK, while 5-FU exposure of these cell lines only induced NF-κB, suggesting that NF-κB plays a dominant role in the response to 5-FU. Subsequent siRNA experiments confirmed that gene knockdown of NF-κB increased 5-FU-specific sensitivity, whereas that of JNK did not affect the chemosensitivity. These results suggest that the expression of these proteins may aid in the decisions involved with adjuvant chemotherapy for gastrointestinal tract cancers." @default.
• W1986086154 created "2016-06-24" @default.
• W1986086154 creator A5005448156 @default.
• W1986086154 creator A5006802809 @default.
• W1986086154 creator A5006999699 @default.
• W1986086154 creator A5011517986 @default.
• W1986086154 creator A5012296767 @default.
• W1986086154 creator A5031997380 @default.
• W1986086154 creator A5035489073 @default.
• W1986086154 creator A5039290790 @default.
• W1986086154 creator A5040657319 @default.
• W1986086154 creator A5042824097 @default.
• W1986086154 creator A5044747383 @default.
• W1986086154 creator A5050596316 @default.
• W1986086154 creator A5053353801 @default.
• W1986086154 creator A5058070151 @default.
• W1986086154 creator A5061594189 @default.
• W1986086154 creator A5069823683 @default.
• W1986086154 creator A5084820122 @default.
• W1986086154 creator A5084931223 @default.
• W1986086154 creator A5088420388 @default.
• W1986086154 creator A5088527994 @default.
• W1986086154 creator A5090408259 @default.
• W1986086154 date "2012-08-14" @default.
• W1986086154 modified "2023-09-26" @default.
• W1986086154 title "Molecular Marker Identification for Relapse Prediction in 5-FU-Based Adjuvant Chemotherapy in Gastric and Colorectal Cancers" @default.
• W1986086154 cites W12636511 @default.
• W1986086154 cites W1481925502 @default.
• W1986086154 cites W1529706570 @default.
• W1986086154 cites W1841901440 @default.
• W1986086154 cites W1918229896 @default.
• W1986086154 cites W1958418663 @default.
• W1986086154 cites W1981890525 @default.
• W1986086154 cites W1982097971 @default.
• W1986086154 cites W1988924112 @default.
• W1986086154 cites W2006148821 @default.
• W1986086154 cites W2017285418 @default.
• W1986086154 cites W2018843280 @default.
• W1986086154 cites W2020515626 @default.
• W1986086154 cites W2021533617 @default.
• W1986086154 cites W2021764849 @default.
• W1986086154 cites W2026986976 @default.
• W1986086154 cites W2033586457 @default.
• W1986086154 cites W2040329508 @default.
• W1986086154 cites W2055878807 @default.
• W1986086154 cites W2059940917 @default.
• W1986086154 cites W2068006559 @default.
• W1986086154 cites W2068123273 @default.
• W1986086154 cites W2072273455 @default.
• W1986086154 cites W2079197876 @default.
• W1986086154 cites W2080070482 @default.
• W1986086154 cites W2084216127 @default.
• W1986086154 cites W2084472730 @default.
• W1986086154 cites W2089162873 @default.
• W1986086154 cites W2095161320 @default.
• W1986086154 cites W2109033574 @default.
• W1986086154 cites W2109623522 @default.
• W1986086154 cites W2109740395 @default.
• W1986086154 cites W2114111268 @default.
• W1986086154 cites W2115072149 @default.
• W1986086154 cites W2123125243 @default.
• W1986086154 cites W2133984207 @default.
• W1986086154 cites W2137991416 @default.
• W1986086154 cites W2138095581 @default.
• W1986086154 cites W2140063126 @default.
• W1986086154 cites W2155787647 @default.
• W1986086154 cites W2158257131 @default.
• W1986086154 cites W2159181129 @default.
• W1986086154 cites W2167395325 @default.
• W1986086154 cites W2170596177 @default.
• W1986086154 cites W2183890269 @default.
• W1986086154 cites W2185863287 @default.
• W1986086154 cites W2248739822 @default.
• W1986086154 cites W2291442844 @default.
• W1986086154 cites W2321013404 @default.
• W1986086154 cites W3146474056 @default.
• W1986086154 cites W712570 @default.
• W1986086154 cites W2073174820 @default.
• W1986086154 doi "https://doi.org/10.1371/journal.pone.0043236" @default.
• W1986086154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419205" @default.
• W1986086154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22905237" @default.
• W1986086154 hasPublicationYear "2012" @default.
• W1986086154 type Work @default.
• W1986086154 sameAs 1986086154 @default.
• W1986086154 citedByCount "12" @default.
• W1986086154 countsByYear W19860861542012 @default.
• W1986086154 countsByYear W19860861542014 @default.
• W1986086154 countsByYear W19860861542016 @default.
• W1986086154 countsByYear W19860861542017 @default.
• W1986086154 countsByYear W19860861542018 @default.
• W1986086154 countsByYear W19860861542019 @default.
• W1986086154 countsByYear W19860861542022 @default.
• W1986086154 crossrefType "journal-article" @default.
• W1986086154 hasAuthorship W1986086154A5005448156 @default.
• W1986086154 hasAuthorship W1986086154A5006802809 @default.
• W1986086154 hasAuthorship W1986086154A5006999699 @default.
• W1986086154 hasAuthorship W1986086154A5011517986 @default.
• W1986086154 hasAuthorship W1986086154A5012296767 @default.

• next