FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986088396> ?p ?o ?g. }

• W1986088396 endingPage "74" @default.
• W1986088396 startingPage "67" @default.
• W1986088396 abstract "Neuroblastoma shows remarkable heterogeneity, resulting in favorable and unfavorable outcomes. It is well known that almost all cases with MYCN amplification have a poor prognosis. We have previously reported that unfavorable tumors show high telomerase activity, whereas favorable tumors show low or nil activity. We also found that the unfavorable neuroblastoma often have a loss of heterozygosity (LOH) at the MYCL locus.To clarify the biological and clinical profiles of tumors with genetic abnormalities of the short arm of chromosome 1, we performed deletion mapping on 1p on 92 neuroblastoma tissues and corresponding noncancerous samples obtained from 92 cases for 24 micro- or minisatellite loci.LOH was detected in at least one locus of 1p in 43 (47%) cases. All samples were classified into four groups according to the deleted pattern: interstitial deletion (group I, n = 20), short terminal deletion (group ST, n = 6), large terminal deletion (group LT, n = 17), and without detectable deletion (group N, n = 49). All group I cases, whose SRO (shortest region of overlap) was at 1p36.1-2, survived disease free, and none of them showed MYCN amplification or high telomerase activity except for one case. On the other hand, in group LT cases, who showed a large terminal deletion from D1S162 (1p32-pter), including the SRO of group 1, only 5 out of 17 have survived disease free, and 13 showed MYCN amplification or high telomerase activity. The six group ST cases showed small terminal deletion from 1p36.3 with modest prognosis, similar to the group N.Thus, we propose three loci, 1p36.1-2, 1p32-34, and 1p36.3, as the candidate loci of neuroblastoma suppressor genes on chromosome 1p responsible for groups I, LT, and ST, respectively. Among them, the 1p32-34 locus may be associated with aggressiveness of tumor progression, possibly due to MYCN amplification and/or telomerase reactivation, while the remaining two loci may not." @default.
• W1986088396 created "2016-06-24" @default.
• W1986088396 creator A5025205330 @default.
• W1986088396 creator A5027332600 @default.
• W1986088396 creator A5027813941 @default.
• W1986088396 creator A5054111527 @default.
• W1986088396 creator A5056910408 @default.
• W1986088396 creator A5057299831 @default.
• W1986088396 creator A5039876694 @default.
• W1986088396 date "2001-01-01" @default.
• W1986088396 modified "2023-09-25" @default.
• W1986088396 title "Biological characteristics of neuroblastoma with partial deletion in the short arm of chromosome 1" @default.
• W1986088396 cites W1971856593 @default.
• W1986088396 cites W1980323135 @default.
• W1986088396 cites W1985064409 @default.
• W1986088396 cites W1986538121 @default.
• W1986088396 cites W1991081820 @default.
• W1986088396 cites W2000971601 @default.
• W1986088396 cites W2003462368 @default.
• W1986088396 cites W2007476455 @default.
• W1986088396 cites W2009263545 @default.
• W1986088396 cites W2011329576 @default.
• W1986088396 cites W2011923500 @default.
• W1986088396 cites W2024280594 @default.
• W1986088396 cites W2050275508 @default.
• W1986088396 cites W2059090231 @default.
• W1986088396 cites W2061438510 @default.
• W1986088396 cites W2067911673 @default.
• W1986088396 cites W2071059965 @default.
• W1986088396 cites W2073611916 @default.
• W1986088396 cites W2079612777 @default.
• W1986088396 cites W2148805136 @default.
• W1986088396 cites W2244393570 @default.
• W1986088396 cites W2264275593 @default.
• W1986088396 cites W2326401583 @default.
• W1986088396 cites W2330923897 @default.
• W1986088396 cites W2337863645 @default.
• W1986088396 doi "https://doi.org/10.1002/1096-911x(20010101)36:1<67::aid-mpo1017>3.0.co;2-s" @default.
• W1986088396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11464909" @default.
• W1986088396 hasPublicationYear "2001" @default.
• W1986088396 type Work @default.
• W1986088396 sameAs 1986088396 @default.
• W1986088396 citedByCount "24" @default.
• W1986088396 countsByYear W19860883962012 @default.
• W1986088396 countsByYear W19860883962013 @default.
• W1986088396 countsByYear W19860883962014 @default.
• W1986088396 countsByYear W19860883962019 @default.
• W1986088396 countsByYear W19860883962022 @default.
• W1986088396 crossrefType "journal-article" @default.
• W1986088396 hasAuthorship W1986088396A5025205330 @default.
• W1986088396 hasAuthorship W1986088396A5027332600 @default.
• W1986088396 hasAuthorship W1986088396A5027813941 @default.
• W1986088396 hasAuthorship W1986088396A5039876694 @default.
• W1986088396 hasAuthorship W1986088396A5054111527 @default.
• W1986088396 hasAuthorship W1986088396A5056910408 @default.
• W1986088396 hasAuthorship W1986088396A5057299831 @default.
• W1986088396 hasConcept C104317684 @default.
• W1986088396 hasConcept C143589142 @default.
• W1986088396 hasConcept C153911025 @default.
• W1986088396 hasConcept C180754005 @default.
• W1986088396 hasConcept C2776715637 @default.
• W1986088396 hasConcept C3020253223 @default.
• W1986088396 hasConcept C30481170 @default.
• W1986088396 hasConcept C502942594 @default.
• W1986088396 hasConcept C54355233 @default.
• W1986088396 hasConcept C61320498 @default.
• W1986088396 hasConcept C71924100 @default.
• W1986088396 hasConcept C81885089 @default.
• W1986088396 hasConcept C84597430 @default.
• W1986088396 hasConcept C86803240 @default.
• W1986088396 hasConcept C93720030 @default.
• W1986088396 hasConcept C94581717 @default.
• W1986088396 hasConceptScore W1986088396C104317684 @default.
• W1986088396 hasConceptScore W1986088396C143589142 @default.
• W1986088396 hasConceptScore W1986088396C153911025 @default.
• W1986088396 hasConceptScore W1986088396C180754005 @default.
• W1986088396 hasConceptScore W1986088396C2776715637 @default.
• W1986088396 hasConceptScore W1986088396C3020253223 @default.
• W1986088396 hasConceptScore W1986088396C30481170 @default.
• W1986088396 hasConceptScore W1986088396C502942594 @default.
• W1986088396 hasConceptScore W1986088396C54355233 @default.
• W1986088396 hasConceptScore W1986088396C61320498 @default.
• W1986088396 hasConceptScore W1986088396C71924100 @default.
• W1986088396 hasConceptScore W1986088396C81885089 @default.
• W1986088396 hasConceptScore W1986088396C84597430 @default.
• W1986088396 hasConceptScore W1986088396C86803240 @default.
• W1986088396 hasConceptScore W1986088396C93720030 @default.
• W1986088396 hasConceptScore W1986088396C94581717 @default.
• W1986088396 hasIssue "1" @default.
• W1986088396 hasLocation W19860883961 @default.
• W1986088396 hasLocation W19860883962 @default.
• W1986088396 hasOpenAccess W1986088396 @default.
• W1986088396 hasPrimaryLocation W19860883961 @default.
• W1986088396 hasRelatedWork W127700499 @default.
• W1986088396 hasRelatedWork W1481453705 @default.
• W1986088396 hasRelatedWork W1986088396 @default.
• W1986088396 hasRelatedWork W2012501870 @default.
• W1986088396 hasRelatedWork W2056071663 @default.

• next