Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986100643> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1986100643 abstract "The molecular mechanisms for general anesthesia are probably restricted to a sensitive set of target sites in the brain. Membrane hyperpolarization, brought about by increased potassium channel conductance, is coupled to opiate mu receptors, to alpha 2- adrenoceptors, and to muscarinic M2 receptors, all of which have anesthetic-sparing effects. One type of potassium channel, the ATP-sensitive potassium channel (IKATP) has well-known agonists: cromakalim and pinacidil. The effects on isoflurane minimum alveolar concentration (MAC) of intracerebroventricular injection of these IKATP agonists and of the alpha 2-adrenoceptor agonist clonidine were studied in rats. Baseline MAC was 1.60% (+/- 0.02 SEM) isoflurane in oxygen. 10 micrograms clonidine decreased MAC by 42% of baseline (P less than 0.05); 20 micrograms clonidine decreased MAC by 58% of baseline (P less than 0.01). Neither cromakalim (20 micrograms) nor pinacidil (20 micrograms) had any effect on MAC. The results imply that neither indiscriminate agonist action of volatile anesthetics at potassium channels nor indiscriminate inhibitory membrane hyperpolarization is likely to be a fundamental mechanism of anesthesia. Furthermore, potassium channels coupled to opiate mu receptors, to alpha 2 adrenoceptors, and to muscarinic M2 receptors are probably not the IKATP type." @default.
- W1986100643 created "2016-06-24" @default.
- W1986100643 creator A5019884885 @default.
- W1986100643 date "1992-04-01" @default.
- W1986100643 modified "2023-09-25" @default.
- W1986100643 title "ATP-sensitive Potassium Channel Agonists Do Not Alter MAC for Isoflurane in Rats" @default.
- W1986100643 doi "https://doi.org/10.1097/00000542-199204000-00012" @default.
- W1986100643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1550281" @default.
- W1986100643 hasPublicationYear "1992" @default.
- W1986100643 type Work @default.
- W1986100643 sameAs 1986100643 @default.
- W1986100643 citedByCount "5" @default.
- W1986100643 countsByYear W19861006432012 @default.
- W1986100643 crossrefType "journal-article" @default.
- W1986100643 hasAuthorship W1986100643A5019884885 @default.
- W1986100643 hasBestOaLocation W19861006431 @default.
- W1986100643 hasConcept C12554922 @default.
- W1986100643 hasConcept C126322002 @default.
- W1986100643 hasConcept C131453863 @default.
- W1986100643 hasConcept C134018914 @default.
- W1986100643 hasConcept C170493617 @default.
- W1986100643 hasConcept C181911157 @default.
- W1986100643 hasConcept C185592680 @default.
- W1986100643 hasConcept C2775984225 @default.
- W1986100643 hasConcept C2776359302 @default.
- W1986100643 hasConcept C2777194220 @default.
- W1986100643 hasConcept C2778162923 @default.
- W1986100643 hasConcept C2778750930 @default.
- W1986100643 hasConcept C2778938600 @default.
- W1986100643 hasConcept C2779166228 @default.
- W1986100643 hasConcept C2779768347 @default.
- W1986100643 hasConcept C2780561956 @default.
- W1986100643 hasConcept C2781063702 @default.
- W1986100643 hasConcept C33789571 @default.
- W1986100643 hasConcept C42219234 @default.
- W1986100643 hasConcept C555293320 @default.
- W1986100643 hasConcept C66974803 @default.
- W1986100643 hasConcept C71240020 @default.
- W1986100643 hasConcept C71924100 @default.
- W1986100643 hasConcept C83743174 @default.
- W1986100643 hasConcept C86803240 @default.
- W1986100643 hasConcept C98274493 @default.
- W1986100643 hasConceptScore W1986100643C12554922 @default.
- W1986100643 hasConceptScore W1986100643C126322002 @default.
- W1986100643 hasConceptScore W1986100643C131453863 @default.
- W1986100643 hasConceptScore W1986100643C134018914 @default.
- W1986100643 hasConceptScore W1986100643C170493617 @default.
- W1986100643 hasConceptScore W1986100643C181911157 @default.
- W1986100643 hasConceptScore W1986100643C185592680 @default.
- W1986100643 hasConceptScore W1986100643C2775984225 @default.
- W1986100643 hasConceptScore W1986100643C2776359302 @default.
- W1986100643 hasConceptScore W1986100643C2777194220 @default.
- W1986100643 hasConceptScore W1986100643C2778162923 @default.
- W1986100643 hasConceptScore W1986100643C2778750930 @default.
- W1986100643 hasConceptScore W1986100643C2778938600 @default.
- W1986100643 hasConceptScore W1986100643C2779166228 @default.
- W1986100643 hasConceptScore W1986100643C2779768347 @default.
- W1986100643 hasConceptScore W1986100643C2780561956 @default.
- W1986100643 hasConceptScore W1986100643C2781063702 @default.
- W1986100643 hasConceptScore W1986100643C33789571 @default.
- W1986100643 hasConceptScore W1986100643C42219234 @default.
- W1986100643 hasConceptScore W1986100643C555293320 @default.
- W1986100643 hasConceptScore W1986100643C66974803 @default.
- W1986100643 hasConceptScore W1986100643C71240020 @default.
- W1986100643 hasConceptScore W1986100643C71924100 @default.
- W1986100643 hasConceptScore W1986100643C83743174 @default.
- W1986100643 hasConceptScore W1986100643C86803240 @default.
- W1986100643 hasConceptScore W1986100643C98274493 @default.
- W1986100643 hasLocation W19861006431 @default.
- W1986100643 hasLocation W19861006432 @default.
- W1986100643 hasOpenAccess W1986100643 @default.
- W1986100643 hasPrimaryLocation W19861006431 @default.
- W1986100643 hasRelatedWork W1986100643 @default.
- W1986100643 hasRelatedWork W1992439885 @default.
- W1986100643 hasRelatedWork W1992917418 @default.
- W1986100643 hasRelatedWork W2022417072 @default.
- W1986100643 hasRelatedWork W2068974235 @default.
- W1986100643 hasRelatedWork W2075382620 @default.
- W1986100643 hasRelatedWork W2105954687 @default.
- W1986100643 hasRelatedWork W2131885033 @default.
- W1986100643 hasRelatedWork W4244856138 @default.
- W1986100643 hasRelatedWork W2117405876 @default.
- W1986100643 isParatext "false" @default.
- W1986100643 isRetracted "false" @default.
- W1986100643 magId "1986100643" @default.
- W1986100643 workType "article" @default.