FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986102181> ?p ?o ?g. }

• W1986102181 endingPage "52" @default.
• W1986102181 startingPage "43" @default.
• W1986102181 abstract "<i>Background/Aims:</i> Dopamine (DA) inhibits prolactin release and reduces lactotroph proliferation by activating D2 receptors. DA and its metabolite, 6-hydroxydopamine (6-OHDA), induce apoptosis in different cell types. DA receptors and DA transporter (DAT) were implicated in this action. Considering that estradiol sensitizes anterior pituitary cells to proapoptotic stimuli, we investigated the effect of estradiol on the apoptotic action of DA and 6-OHDA in anterior pituitary cells, and the involvement of the D2 receptor and DAT in the proapoptotic effect of DA. <i>Methods:</i> Viability of cultured anterior pituitary cells from ovariectomized rats was determined by MTS assay. Apoptosis was evaluated by Annexin-V/flow cytometry and TUNEL. Lactotrophs were identified by immunocytochemistry. <i>Results:</i> DA induced apoptosis of lactotrophs in an estrogen-dependent manner. In contrast, estradiol was not required to trigger the apoptotic action of 6-OHDA. Cabergoline, a D2 receptor agonist, induced lactotroph apoptosis, while sulpiride, a D2 receptor antagonist, blocked DA-induced cell death. The blockade of DAT by GBR12909 did not affect the apoptotic action of DA, but inhibited 6-OHDA-induced apoptosis. <i>Conclusion:</i> These data show that DA, through D2 receptor activation, induces apoptosis of estrogen-sensitized anterior pituitary cells, and suggest that DA contributes to the control of lactotroph number not only by inhibiting proliferation but also by inducing apoptosis." @default.
• W1986102181 created "2016-06-24" @default.
• W1986102181 creator A5006737162 @default.
• W1986102181 creator A5006956143 @default.
• W1986102181 creator A5013684987 @default.
• W1986102181 creator A5031698252 @default.
• W1986102181 creator A5043186952 @default.
• W1986102181 creator A5044111653 @default.
• W1986102181 creator A5047501960 @default.
• W1986102181 creator A5082040646 @default.
• W1986102181 date "2008-01-01" @default.
• W1986102181 modified "2023-10-18" @default.
• W1986102181 title "Apoptosis of Lactotrophs Induced by D2 Receptor Activation Is Estrogen Dependent" @default.
• W1986102181 cites W1500803323 @default.
• W1986102181 cites W1530276807 @default.
• W1986102181 cites W1778706801 @default.
• W1986102181 cites W1925492557 @default.
• W1986102181 cites W1971568125 @default.
• W1986102181 cites W1973248478 @default.
• W1986102181 cites W1973286582 @default.
• W1986102181 cites W1973288768 @default.
• W1986102181 cites W1976507766 @default.
• W1986102181 cites W1987884513 @default.
• W1986102181 cites W1990625891 @default.
• W1986102181 cites W1997845538 @default.
• W1986102181 cites W1997979763 @default.
• W1986102181 cites W1999969387 @default.
• W1986102181 cites W2007515300 @default.
• W1986102181 cites W2013791230 @default.
• W1986102181 cites W2017283375 @default.
• W1986102181 cites W2028284278 @default.
• W1986102181 cites W2045711003 @default.
• W1986102181 cites W2049832435 @default.
• W1986102181 cites W2049870433 @default.
• W1986102181 cites W2054278011 @default.
• W1986102181 cites W2057241152 @default.
• W1986102181 cites W2057451803 @default.
• W1986102181 cites W2060778582 @default.
• W1986102181 cites W2063758018 @default.
• W1986102181 cites W2068527384 @default.
• W1986102181 cites W2072890269 @default.
• W1986102181 cites W2076142003 @default.
• W1986102181 cites W2076546188 @default.
• W1986102181 cites W2079231229 @default.
• W1986102181 cites W2083749681 @default.
• W1986102181 cites W2084542161 @default.
• W1986102181 cites W2085137514 @default.
• W1986102181 cites W2100322500 @default.
• W1986102181 cites W2113103296 @default.
• W1986102181 cites W2117766577 @default.
• W1986102181 cites W2156008877 @default.
• W1986102181 cites W2170825600 @default.
• W1986102181 cites W3146421982 @default.
• W1986102181 cites W1590215417 @default.
• W1986102181 doi "https://doi.org/10.1159/000116117" @default.
• W1986102181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18259092" @default.
• W1986102181 hasPublicationYear "2008" @default.
• W1986102181 type Work @default.
• W1986102181 sameAs 1986102181 @default.
• W1986102181 citedByCount "33" @default.
• W1986102181 countsByYear W19861021812012 @default.
• W1986102181 countsByYear W19861021812013 @default.
• W1986102181 countsByYear W19861021812014 @default.
• W1986102181 countsByYear W19861021812015 @default.
• W1986102181 countsByYear W19861021812017 @default.
• W1986102181 countsByYear W19861021812019 @default.
• W1986102181 countsByYear W19861021812020 @default.
• W1986102181 countsByYear W19861021812021 @default.
• W1986102181 countsByYear W19861021812022 @default.
• W1986102181 crossrefType "journal-article" @default.
• W1986102181 hasAuthorship W1986102181A5006737162 @default.
• W1986102181 hasAuthorship W1986102181A5006956143 @default.
• W1986102181 hasAuthorship W1986102181A5013684987 @default.
• W1986102181 hasAuthorship W1986102181A5031698252 @default.
• W1986102181 hasAuthorship W1986102181A5043186952 @default.
• W1986102181 hasAuthorship W1986102181A5044111653 @default.
• W1986102181 hasAuthorship W1986102181A5047501960 @default.
• W1986102181 hasAuthorship W1986102181A5082040646 @default.
• W1986102181 hasConcept C121608353 @default.
• W1986102181 hasConcept C126322002 @default.
• W1986102181 hasConcept C134018914 @default.
• W1986102181 hasConcept C170493617 @default.
• W1986102181 hasConcept C185592680 @default.
• W1986102181 hasConcept C190283241 @default.
• W1986102181 hasConcept C2778938600 @default.
• W1986102181 hasConcept C2779029589 @default.
• W1986102181 hasConcept C2779064019 @default.
• W1986102181 hasConcept C44208683 @default.
• W1986102181 hasConcept C513476851 @default.
• W1986102181 hasConcept C530470458 @default.
• W1986102181 hasConcept C54799321 @default.
• W1986102181 hasConcept C55493867 @default.
• W1986102181 hasConcept C71315377 @default.
• W1986102181 hasConcept C71924100 @default.
• W1986102181 hasConcept C84606932 @default.
• W1986102181 hasConcept C86803240 @default.
• W1986102181 hasConceptScore W1986102181C121608353 @default.
• W1986102181 hasConceptScore W1986102181C126322002 @default.

• next