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- W1986110815 abstract "Ca2+ signaling is ubiquitous across cell types. Ca2+ liberation through inositol 1,4,5-trisphosphate receptors (IP3Rs) is a key component of the Ca2+ signaling toolkit. The role of cytosolic calcium on the kinetics of IP3R's and on the dynamics of the evoked signals has been studied at large both experimentally and by modeling. The role of luminal calcium has not been investigated with that much detail although it has been found that it is relevant for signal termination in the case of Ca2+ release through Ryanodine Receptors. In this work we present the results of observing the dynamics of luminal and cytosolic Ca2+ simultaneously in Xenopus Laevis oocytes using two dyes that have their peaks of emission at different wavelengths. Through a continuous photorelease of caged IP3 we are able to evoke a series of global and localized signals in this system. The analysis of such signals allows a characterization of the extent to which distant regions can be coupled via the dynamics of luminal calcium. In this way we expect to advance into answering whether luminal calcium can generate the global feedback mechanism that is necessary to explain the robustness of IP3R-mediated calcium spikes as a signaling tool in spite of the inter-spike interval randomness." @default.
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- W1986110815 date "2014-01-01" @default.
- W1986110815 modified "2023-10-17" @default.
- W1986110815 title "Observing the Dynamics of Luminal and Cytosolic Calcium During IP3R-Mediated Calcium Signals" @default.
- W1986110815 doi "https://doi.org/10.1016/j.bpj.2013.11.2967" @default.
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