Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986135912> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1986135912 endingPage "318" @default.
- W1986135912 startingPage "313" @default.
- W1986135912 abstract "Two major epidemics of viral encephalitis occurred in Asia in 1997 and 1998. The first was a re-emergence of neurovirulent strains of enterovirus 71, which caused severe encephalomyelitis in children in Malaysia, Taiwan and Japan, on a background of hand, foot and mouth disease. Necropsy studies of patients who died of enterovirus 71 infection showed severe perivascular cuffing, parenchymal inflammation and neuronophagia in the spinal cord, brainstem and diencephalon, and in focal areas in the cerebellum and cerebrum. Although no viral inclusions were detected, immunohistochemistry showed viral antigen in the neuronal cytoplasm. Inflammation was often more extensive than neuronal infection, suggesting that other factors, in addition to direct viral cytolysis, may be involved in tissue damage. The second epidemic of viral encephalitis was the result of a novel paramyxovirus called Nipah, which mainly involved pig handlers in Malaysia and Singapore. Pathological evidence suggested that the endothelium of small blood vessels in the central nervous system was particularly susceptible to infection. This led to disseminated endothelial damage and syncytium formation, vasculitis, thrombosis, ischaemia and microinfarction. However, there was also evidence of neuronal infection by the virus and this may also have contributed to the neurological dysfunction in Nipah encephalitis. Some patients who seemed to recover from the acute symptoms have been re-admitted with clinical findings suggestive of relapsing encephalitis. As these two epidemics indicate, the emergence and re-emergence of viral encephalitides continue to pose considerable challenges to the neuropathologist, in establishing the diagnosis and unravelling the pathogenesis of the neurological disease." @default.
- W1986135912 created "2016-06-24" @default.
- W1986135912 creator A5062809472 @default.
- W1986135912 date "2000-08-01" @default.
- W1986135912 modified "2023-09-26" @default.
- W1986135912 title "Emerging and re-emerging epidemic encephalitis: a tale of two viruses" @default.
- W1986135912 cites W1546665933 @default.
- W1986135912 cites W1973647109 @default.
- W1986135912 cites W1974055785 @default.
- W1986135912 cites W1980148349 @default.
- W1986135912 cites W1981329413 @default.
- W1986135912 cites W1992147205 @default.
- W1986135912 cites W2003330498 @default.
- W1986135912 cites W2004775359 @default.
- W1986135912 cites W2017093959 @default.
- W1986135912 cites W2017439898 @default.
- W1986135912 cites W2043378589 @default.
- W1986135912 cites W2056774432 @default.
- W1986135912 cites W2062224760 @default.
- W1986135912 cites W2073186580 @default.
- W1986135912 cites W2091736213 @default.
- W1986135912 cites W2100008113 @default.
- W1986135912 cites W2114345831 @default.
- W1986135912 cites W2129930722 @default.
- W1986135912 cites W2131714664 @default.
- W1986135912 cites W2137477090 @default.
- W1986135912 cites W2146067302 @default.
- W1986135912 cites W2169001784 @default.
- W1986135912 cites W2315624236 @default.
- W1986135912 doi "https://doi.org/10.1046/j.1365-2990.2000.00256.x" @default.
- W1986135912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10931364" @default.
- W1986135912 hasPublicationYear "2000" @default.
- W1986135912 type Work @default.
- W1986135912 sameAs 1986135912 @default.
- W1986135912 citedByCount "34" @default.
- W1986135912 countsByYear W19861359122012 @default.
- W1986135912 countsByYear W19861359122013 @default.
- W1986135912 countsByYear W19861359122014 @default.
- W1986135912 countsByYear W19861359122015 @default.
- W1986135912 countsByYear W19861359122016 @default.
- W1986135912 crossrefType "journal-article" @default.
- W1986135912 hasAuthorship W1986135912A5062809472 @default.
- W1986135912 hasConcept C142724271 @default.
- W1986135912 hasConcept C159047783 @default.
- W1986135912 hasConcept C203014093 @default.
- W1986135912 hasConcept C2522874641 @default.
- W1986135912 hasConcept C2776015282 @default.
- W1986135912 hasConcept C2777888124 @default.
- W1986135912 hasConcept C2777899865 @default.
- W1986135912 hasConcept C2778889330 @default.
- W1986135912 hasConcept C2779134260 @default.
- W1986135912 hasConcept C2779141303 @default.
- W1986135912 hasConcept C2779734145 @default.
- W1986135912 hasConcept C2780640218 @default.
- W1986135912 hasConcept C2780942790 @default.
- W1986135912 hasConcept C71924100 @default.
- W1986135912 hasConcept C83455156 @default.
- W1986135912 hasConcept C86803240 @default.
- W1986135912 hasConceptScore W1986135912C142724271 @default.
- W1986135912 hasConceptScore W1986135912C159047783 @default.
- W1986135912 hasConceptScore W1986135912C203014093 @default.
- W1986135912 hasConceptScore W1986135912C2522874641 @default.
- W1986135912 hasConceptScore W1986135912C2776015282 @default.
- W1986135912 hasConceptScore W1986135912C2777888124 @default.
- W1986135912 hasConceptScore W1986135912C2777899865 @default.
- W1986135912 hasConceptScore W1986135912C2778889330 @default.
- W1986135912 hasConceptScore W1986135912C2779134260 @default.
- W1986135912 hasConceptScore W1986135912C2779141303 @default.
- W1986135912 hasConceptScore W1986135912C2779734145 @default.
- W1986135912 hasConceptScore W1986135912C2780640218 @default.
- W1986135912 hasConceptScore W1986135912C2780942790 @default.
- W1986135912 hasConceptScore W1986135912C71924100 @default.
- W1986135912 hasConceptScore W1986135912C83455156 @default.
- W1986135912 hasConceptScore W1986135912C86803240 @default.
- W1986135912 hasIssue "4" @default.
- W1986135912 hasLocation W19861359121 @default.
- W1986135912 hasLocation W19861359122 @default.
- W1986135912 hasOpenAccess W1986135912 @default.
- W1986135912 hasPrimaryLocation W19861359121 @default.
- W1986135912 hasRelatedWork W1971986234 @default.
- W1986135912 hasRelatedWork W1978128154 @default.
- W1986135912 hasRelatedWork W1986135912 @default.
- W1986135912 hasRelatedWork W2144567501 @default.
- W1986135912 hasRelatedWork W2349770278 @default.
- W1986135912 hasRelatedWork W2379936563 @default.
- W1986135912 hasRelatedWork W2410663187 @default.
- W1986135912 hasRelatedWork W2419859719 @default.
- W1986135912 hasRelatedWork W2977871080 @default.
- W1986135912 hasRelatedWork W4247421605 @default.
- W1986135912 hasVolume "26" @default.
- W1986135912 isParatext "false" @default.
- W1986135912 isRetracted "false" @default.
- W1986135912 magId "1986135912" @default.
- W1986135912 workType "article" @default.