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- W1986136996 abstract "ABSTRACT The ability of Staphylococcus aureus to adapt to different environments is due to a regulatory network comprising several loci. Here we present a detailed study of the interaction between the two global regulators sae and σ B of S. aureus and their influence on virulence gene expression in vitro, as well as during device-related infection. The expression of sae , asp23 , hla , clfA , coa , and fnbA was determined in strain Newman and its isogenic saeS/R and sigB mutants by Northern analysis and LightCycler reverse transcription-PCR. There was no indication of direct cross talk between the two regulators. sae had a dominant effect on target gene expression during device-related infection. σ B seemed to be less active throughout the infection than under induced conditions in vitro." @default.
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- W1986136996 date "2005-06-01" @default.
- W1986136996 modified "2023-10-17" @default.
- W1986136996 title "Role of <i>Staphylococcus aureus</i> Global Regulators <i>sae</i> and σ <sup>B</sup> in Virulence Gene Expression during Device-Related Infection" @default.
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- W1986136996 doi "https://doi.org/10.1128/iai.73.6.3415-3421.2005" @default.
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