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• W1986138525 endingPage "1054" @default.
• W1986138525 startingPage "1039" @default.
• W1986138525 abstract "NMDA receptor (NMDA-R) is an important molecular entity governing a wide range of functions in the central nervous system. For example, the NMDA-R is involved in memory and cognition, and impairment of both (as in Alzheimer’s Disease) is attributed to NMDA-mediated neurotoxicity. With greater understanding of the NMDA-R structure, antagonists with varying degrees of binding-site and subtype selectivity have been developed and put into clinical use. Discovery of target-specific Chinese herbs have also been made in parallel. This article provides an overview of the known active sites on the NMDA-R, followed by a discussion of the relevant herbs and their constituents. Experimental evidence supporting the inhibitory role of the herbal compounds on the NMDA-R is highlighted. For some of the compounds, potential research directions are also proposed to further elucidate the underlying mechanisms of the herbs. It is envisaged that future investigations based on the present data will allow more clinically relevant herbs to be identified." @default.
• W1986138525 created "2016-06-24" @default.
• W1986138525 creator A5039909478 @default.
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• W1986138525 creator A5063609958 @default.
• W1986138525 creator A5070376634 @default.
• W1986138525 creator A5081255202 @default.
• W1986138525 date "2013-08-21" @default.
• W1986138525 modified "2023-10-18" @default.
• W1986138525 title "Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade" @default.
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• W1986138525 doi "https://doi.org/10.3390/ph6081039" @default.
• W1986138525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3817734" @default.
• W1986138525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24276380" @default.
• W1986138525 hasPublicationYear "2013" @default.
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