FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986150755> ?p ?o ?g. }

• W1986150755 endingPage "261" @default.
• W1986150755 startingPage "251" @default.
• W1986150755 abstract "Background Prenatal alcohol exposure (PAE) is associated with alterations in numerous physiological systems, including the stress and immune systems. We have previously shown that PAE increases the course and severity of arthritis in an adjuvant‐induced arthritis (AA) model. While the molecular mechanisms underlying these effects are not fully known, changes in neural gene expression are emerging as important factors in the etiology of PAE effects. As the prefrontal cortex (PFC) and hippocampus (HPC) play key roles in neuroimmune function, PAE‐induced alterations to their transcriptome may underlie abnormal steady‐state functions and responses to immune challenge. This study examined brains from adult PAE and control females from our recent AA study to determine whether PAE causes long‐term alterations in gene expression and whether these mediate the altered severity and course of arthritis in PAE females. Methods Adult females from PAE, pair‐fed (PF), and ad libitum ‐ fed control (C) groups were injected with either saline or complete Freund's adjuvant. Animals were terminated at the peak of inflammation or during resolution (Days 16 and 39 postinjection, respectively); cohorts of saline‐injected PAE, PF, and C females were terminated in parallel. Gene expression was analyzed in the PFC and HPC using whole‐genome mRNA expression microarrays. Results Significant changes in gene expression in both the PFC and HPC were found in PAE compared to controls in response to ethanol exposure alone (saline‐injected females), including genes involved in neurodevelopment, apoptosis, and energy metabolism. Moreover, in response to inflammation (adjuvant‐injected females), PAE animals showed unique expression patterns, while failing to exhibit the activation of genes and regulators involved in the immune response observed in control and pair‐fed animals. Conclusions These results support the hypothesis that PAE affects neuroimmune function at the level of gene expression, demonstrating long‐term effects of PAE on the central nervous system response under steady‐state conditions and following an inflammatory insult." @default.
• W1986150755 created "2016-06-24" @default.
• W1986150755 creator A5001139144 @default.
• W1986150755 creator A5012991069 @default.
• W1986150755 creator A5037987356 @default.
• W1986150755 creator A5063202841 @default.
• W1986150755 creator A5073729222 @default.
• W1986150755 creator A5082761941 @default.
• W1986150755 date "2015-02-01" @default.
• W1986150755 modified "2023-10-03" @default.
• W1986150755 title "Prenatal Alcohol Exposure Alters Steady-State and Activated Gene Expression in the Adult Rat Brain" @default.
• W1986150755 cites W1487018400 @default.
• W1986150755 cites W1526723238 @default.
• W1986150755 cites W1546952499 @default.
• W1986150755 cites W1577577364 @default.
• W1986150755 cites W1579104068 @default.
• W1986150755 cites W1766347659 @default.
• W1986150755 cites W1825161527 @default.
• W1986150755 cites W1963524612 @default.
• W1986150755 cites W1964401196 @default.
• W1986150755 cites W1970497986 @default.
• W1986150755 cites W1970762797 @default.
• W1986150755 cites W1972618119 @default.
• W1986150755 cites W1984328128 @default.
• W1986150755 cites W2001214757 @default.
• W1986150755 cites W2003409456 @default.
• W1986150755 cites W2003638783 @default.
• W1986150755 cites W2004732671 @default.
• W1986150755 cites W2006395734 @default.
• W1986150755 cites W2008183439 @default.
• W1986150755 cites W2016964866 @default.
• W1986150755 cites W2020017800 @default.
• W1986150755 cites W2032997652 @default.
• W1986150755 cites W2039719578 @default.
• W1986150755 cites W2042207199 @default.
• W1986150755 cites W2051185092 @default.
• W1986150755 cites W2075946905 @default.
• W1986150755 cites W2079475646 @default.
• W1986150755 cites W2084418847 @default.
• W1986150755 cites W2086092086 @default.
• W1986150755 cites W2090122454 @default.
• W1986150755 cites W2092670527 @default.
• W1986150755 cites W2103765038 @default.
• W1986150755 cites W2111440739 @default.
• W1986150755 cites W2113336683 @default.
• W1986150755 cites W2114342323 @default.
• W1986150755 cites W2114570899 @default.
• W1986150755 cites W2134889157 @default.
• W1986150755 cites W2136123560 @default.
• W1986150755 cites W2137499573 @default.
• W1986150755 cites W2140636567 @default.
• W1986150755 cites W2149848093 @default.
• W1986150755 cites W2150622190 @default.
• W1986150755 cites W2152948116 @default.
• W1986150755 cites W2158256295 @default.
• W1986150755 cites W2169264400 @default.
• W1986150755 cites W2170739059 @default.
• W1986150755 cites W2398640780 @default.
• W1986150755 cites W48225551 @default.
• W1986150755 doi "https://doi.org/10.1111/acer.12622" @default.
• W1986150755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4833439" @default.
• W1986150755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25684047" @default.
• W1986150755 hasPublicationYear "2015" @default.
• W1986150755 type Work @default.
• W1986150755 sameAs 1986150755 @default.
• W1986150755 citedByCount "34" @default.
• W1986150755 countsByYear W19861507552015 @default.
• W1986150755 countsByYear W19861507552016 @default.
• W1986150755 countsByYear W19861507552017 @default.
• W1986150755 countsByYear W19861507552018 @default.
• W1986150755 countsByYear W19861507552019 @default.
• W1986150755 countsByYear W19861507552020 @default.
• W1986150755 countsByYear W19861507552021 @default.
• W1986150755 countsByYear W19861507552022 @default.
• W1986150755 countsByYear W19861507552023 @default.
• W1986150755 crossrefType "journal-article" @default.
• W1986150755 hasAuthorship W1986150755A5001139144 @default.
• W1986150755 hasAuthorship W1986150755A5012991069 @default.
• W1986150755 hasAuthorship W1986150755A5037987356 @default.
• W1986150755 hasAuthorship W1986150755A5063202841 @default.
• W1986150755 hasAuthorship W1986150755A5073729222 @default.
• W1986150755 hasAuthorship W1986150755A5082761941 @default.
• W1986150755 hasBestOaLocation W19861507552 @default.
• W1986150755 hasConcept C104317684 @default.
• W1986150755 hasConcept C126322002 @default.
• W1986150755 hasConcept C134018914 @default.
• W1986150755 hasConcept C150194340 @default.
• W1986150755 hasConcept C162317418 @default.
• W1986150755 hasConcept C169760540 @default.
• W1986150755 hasConcept C169900460 @default.
• W1986150755 hasConcept C186836561 @default.
• W1986150755 hasConcept C203014093 @default.
• W1986150755 hasConcept C2776914184 @default.
• W1986150755 hasConcept C2777077863 @default.
• W1986150755 hasConcept C2781195155 @default.
• W1986150755 hasConcept C54355233 @default.
• W1986150755 hasConcept C71924100 @default.
• W1986150755 hasConcept C86803240 @default.

• next