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• W1986165718 abstract "P275 Aims: Hypertension is a frequent complication of kidney transplantation. Transplant renal artery stenosis (TRAS) is known to be cause of hypertension with a reported incidence from 1% to 25%. Aim of this study was to verify the long-term efficacy and safety of Palmaz stent implantation in the treatment of TRAS. Methods: 26 patients out of our series of 450 consecutive cadaveric renal transplant recipients (5.7%) were affected by hypertension and by some degree of graft dysfunction because of TRAS. 24 were treated by percutaneous transluminal angioplasty (PTA) followed by Palmaz stent permanent insertion. Only two patients were treated by PTA alone. Patients were 15 males and 11 females. Mean age at transplantation was 47.3±9.4 years. In 19 patients the anastomosis was end to side with the iliac common artery and in 7 was end to end with the hypogastric artery. The site of stenosis was anastomotic in 16 cases and post-anastomotic in 10. The techique of stenting implantation was made by Palmaz endoprothesis that is a stainless tube crimped onto the angioplasty balloon. The mean follow-up period was 43.31±33.6 months. 17 patients had had a complete follow-up of three years. Results: The stenosis occurred in the early period post-transplantation (median 6 months). The clinical results of stenting were evaluated determining the mean blood pressure, the renal artery blood flow, the serum creatinine pre-stenting, one month, one year and yearly post-stenting. The mean blood pressure fell significantly one month after stenting (118±8.1 vs 101±7.8 mmHg; p<0.0001); then remained stable (102.4±13.9 at one year). Similarly the number of antihypertensive drugs reduced (2.23±0.99 vs 1.73±0.82; p=0.004). Renal artery blood flow as determined by doppler ultrasonography, reduced from 352.5±56.5 to 157.3±53.7 cm/sec one month after stenting; p<0.0001. Then remained stable (156.7±69.9 cm/sec at one year after stenting). Renal function improved after stenting (serum creatinine: 2.2±1.4 mg/dl pre, 1.7±0.86 at one month, 1.58±0.68 at one year and 1.72±1.05 at 3 years; ANOVA: p<0.05). Conclusions: In the case of severe or recurrent TRAS, the stenting of the renal artery proved to be an effective therapeutic tool. This method with low procedure costs and extremely low complication rate proved to be safe and to offer the potential of preserving lumen patency, improving the long-term efficacy of percutaneous angioplasty." @default.
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• W1986165718 date "2004-07-01" @default.
• W1986165718 modified "2023-10-18" @default.
• W1986165718 title "EFFICACY AND SAFETY OF PALMAZ STENT IMPLANTATION IN THE TREATMENT OF RENAL ARTERY STENOSIS IN RENAL TRANSPLANTATION." @default.
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• W1986165718 doi "https://doi.org/10.1097/00007890-200407271-00770" @default.
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