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- W1986172021 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAGlioblastoma (GBM) stem cells (GSCs) are a subpopulation of tumor cells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, therapeutic resistance and tumor recurrence. It is becoming increasingly important to identify novel therapeutic targets in GSC for anti-GBM therapies. Here, we demonstrate that hyaluronan-mediated motility receptor (HMMR) is hyper-expressed in GBM tumors and supports the self-renewal and tumorigenic potential of GSCs. HMMR silencing impairs GSC self-renewal and inhibits the expression of GSC markers and regulators. HMMR silencing suppresses GSC-derived tumor growth and extends the survival of mice bearing GSC xenografts. HMMR overexpression promotes GSC self-renewal and intracranial tumor propagation. In human GBM tumor specimens, HMMR expression is positively correlated with the expression of cell-stemness-associated markers and regulators. Our findings identify HMMR as a potential therapeutic target for inhibiting GSCs, suggesting therapeutic applications against GBM.Citation Format: Jessica Tilghman, John Laterra, Mingyao Ying. Hyaluronan-mediated motility receptor maintains stemness and tumorigenic potential of glioblastoma stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3014. doi:10.1158/1538-7445.AM2014-3014" @default.
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- W1986172021 date "2014-09-30" @default.
- W1986172021 modified "2023-09-27" @default.
- W1986172021 title "Abstract 3014: Hyaluronan-mediated motility receptor maintains stemness and tumorigenic potential of glioblastoma stem cells" @default.
- W1986172021 doi "https://doi.org/10.1158/1538-7445.am2014-3014" @default.
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