FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986173838> ?p ?o ?g. }

• W1986173838 endingPage "97" @default.
• W1986173838 startingPage "93" @default.
• W1986173838 abstract "Acetaldehyde (AA) is known to induce DNA–protein cross-links (DPX) and other genotoxic and mutagenic effects in cultured mammalian cells. Compared to formaldehyde (FA), AA is a very weak inducer of DPX and increased DPX levels are only measured at high, cytotoxic concentrations by different methods. Besides DPX, AA also induces DNA–DNA cross-links. Because the comet assay is increasingly used for the detection of cross-linking agents, we characterized the effects of AA in the comet assay in relation to cytotoxicity and other genetic endpoints such as the induction of sister chromatid exchange (SCE) and micronuclei (MN). The standard alkaline comet assay did not indicate induction of DNA strand-breaks by AA in a range of concentrations from 0.2 to 20 mM. AA at a concentration of 20 mM was clearly cytotoxic and reduced cell growth and population doubling to less than 50% of the control. Using the comet assay modification with proteinase K, slightly enhanced DNA migration was measured in comparison to treatment with AA only. No significant induction of cross-links by AA (measured as reduction of gamma ray-induced DNA migration) was determined by the comet assay. A small and reproducible but statistically not significant effect was measured for the AA concentration 20 mM. A clear and concentration-related increase in the frequency of sister chromatid exchange (SCE) and micronuclei (MN) was already measured at lower concentrations (0.2 and 0.5 mM, respectively). These results suggest that the comet assay has a low sensitivity for the detection of AA-induced DNA lesions leading to the induction of SCE and MN." @default.
• W1986173838 created "2016-06-24" @default.
• W1986173838 creator A5061177906 @default.
• W1986173838 creator A5061336544 @default.
• W1986173838 creator A5063490103 @default.
• W1986173838 creator A5091367717 @default.
• W1986173838 date "2008-12-01" @default.
• W1986173838 modified "2023-09-27" @default.
• W1986173838 title "Low sensitivity of the comet assay to detect acetaldehyde-induced genotoxicity" @default.
• W1986173838 cites W1967189897 @default.
• W1986173838 cites W1967762868 @default.
• W1986173838 cites W1970577073 @default.
• W1986173838 cites W1977401965 @default.
• W1986173838 cites W1996368444 @default.
• W1986173838 cites W1999388654 @default.
• W1986173838 cites W2007730927 @default.
• W1986173838 cites W2021414181 @default.
• W1986173838 cites W2026825133 @default.
• W1986173838 cites W2035636241 @default.
• W1986173838 cites W2043158304 @default.
• W1986173838 cites W2052810045 @default.
• W1986173838 cites W2053578001 @default.
• W1986173838 cites W2056257023 @default.
• W1986173838 cites W2056810217 @default.
• W1986173838 cites W2059001486 @default.
• W1986173838 cites W2066147719 @default.
• W1986173838 cites W2072560922 @default.
• W1986173838 cites W2082815093 @default.
• W1986173838 cites W2091041044 @default.
• W1986173838 cites W2105413614 @default.
• W1986173838 cites W2112621466 @default.
• W1986173838 cites W2119284085 @default.
• W1986173838 cites W2126616568 @default.
• W1986173838 cites W2127505174 @default.
• W1986173838 cites W2134137595 @default.
• W1986173838 cites W2144808416 @default.
• W1986173838 cites W2147890099 @default.
• W1986173838 cites W2165793882 @default.
• W1986173838 doi "https://doi.org/10.1016/j.mrgentox.2008.07.010" @default.
• W1986173838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18755289" @default.
• W1986173838 hasPublicationYear "2008" @default.
• W1986173838 type Work @default.
• W1986173838 sameAs 1986173838 @default.
• W1986173838 citedByCount "11" @default.
• W1986173838 countsByYear W19861738382013 @default.
• W1986173838 countsByYear W19861738382014 @default.
• W1986173838 countsByYear W19861738382017 @default.
• W1986173838 countsByYear W19861738382019 @default.
• W1986173838 countsByYear W19861738382021 @default.
• W1986173838 countsByYear W19861738382022 @default.
• W1986173838 crossrefType "journal-article" @default.
• W1986173838 hasAuthorship W1986173838A5061177906 @default.
• W1986173838 hasAuthorship W1986173838A5061336544 @default.
• W1986173838 hasAuthorship W1986173838A5063490103 @default.
• W1986173838 hasAuthorship W1986173838A5091367717 @default.
• W1986173838 hasConcept C109316439 @default.
• W1986173838 hasConcept C143425029 @default.
• W1986173838 hasConcept C153911025 @default.
• W1986173838 hasConcept C178790620 @default.
• W1986173838 hasConcept C181199279 @default.
• W1986173838 hasConcept C185592680 @default.
• W1986173838 hasConcept C202751555 @default.
• W1986173838 hasConcept C2778959862 @default.
• W1986173838 hasConcept C2779071816 @default.
• W1986173838 hasConcept C2780358455 @default.
• W1986173838 hasConcept C2908647359 @default.
• W1986173838 hasConcept C29730261 @default.
• W1986173838 hasConcept C45080847 @default.
• W1986173838 hasConcept C538909803 @default.
• W1986173838 hasConcept C552990157 @default.
• W1986173838 hasConcept C55493867 @default.
• W1986173838 hasConcept C71924100 @default.
• W1986173838 hasConcept C86803240 @default.
• W1986173838 hasConcept C87355193 @default.
• W1986173838 hasConcept C94081185 @default.
• W1986173838 hasConcept C99454951 @default.
• W1986173838 hasConceptScore W1986173838C109316439 @default.
• W1986173838 hasConceptScore W1986173838C143425029 @default.
• W1986173838 hasConceptScore W1986173838C153911025 @default.
• W1986173838 hasConceptScore W1986173838C178790620 @default.
• W1986173838 hasConceptScore W1986173838C181199279 @default.
• W1986173838 hasConceptScore W1986173838C185592680 @default.
• W1986173838 hasConceptScore W1986173838C202751555 @default.
• W1986173838 hasConceptScore W1986173838C2778959862 @default.
• W1986173838 hasConceptScore W1986173838C2779071816 @default.
• W1986173838 hasConceptScore W1986173838C2780358455 @default.
• W1986173838 hasConceptScore W1986173838C2908647359 @default.
• W1986173838 hasConceptScore W1986173838C29730261 @default.
• W1986173838 hasConceptScore W1986173838C45080847 @default.
• W1986173838 hasConceptScore W1986173838C538909803 @default.
• W1986173838 hasConceptScore W1986173838C552990157 @default.
• W1986173838 hasConceptScore W1986173838C55493867 @default.
• W1986173838 hasConceptScore W1986173838C71924100 @default.
• W1986173838 hasConceptScore W1986173838C86803240 @default.
• W1986173838 hasConceptScore W1986173838C87355193 @default.
• W1986173838 hasConceptScore W1986173838C94081185 @default.
• W1986173838 hasConceptScore W1986173838C99454951 @default.
• W1986173838 hasIssue "2" @default.

• next