Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986173845> ?p ?o ?g. }
- W1986173845 endingPage "1289" @default.
- W1986173845 startingPage "1277" @default.
- W1986173845 abstract "The therapy for chronic hepatitis C (CH-C) started with interferon (IFN) monotherapy in the early 1990s and this therapy was considered effective in about 10% of cases. The present standard therapy of pegylated IFN with ribavirin achieves a sustained virologic response in about 50% of patients. However, about half of the CH-C patients are still at risk of fatal liver cirrhosis and hepatocellular carcinoma. The other significant event in hepatitis C virus (HCV) research has been the development of a cell culture system. The subgenomic replicon system enables robust HCV RNA replication in hepatoma cells. And recently, the complete life cycle of HCV has been achieved using a genotype 2a strain, JFH1. These hallmarks have provided much information about the mechanisms of HCV replication, including information on the host molecules required for the replication. Anti-HCV reagents targeting HCV proteins have been developed, and some of them are now in clinical trials. However, the RNA-dependent RNA polymerase frequently causes mutations in the HCV genome, which lead to the emergence of drug-resistant HCV mutants. Some of the cellular proteins essential for HCV RNA replication have already been discovered using the HCV cell culture system. These host molecules are also candidate targets for antivirals. Here, we describe the recent progress regarding the anti-HCV reagents targeting host metabolism." @default.
- W1986173845 created "2016-06-24" @default.
- W1986173845 creator A5012169699 @default.
- W1986173845 creator A5041139736 @default.
- W1986173845 date "2007-10-01" @default.
- W1986173845 modified "2023-09-30" @default.
- W1986173845 title "Modulation of host metabolism as a target of new antivirals" @default.
- W1986173845 cites W13321200 @default.
- W1986173845 cites W1535549793 @default.
- W1986173845 cites W1965448125 @default.
- W1986173845 cites W1968899686 @default.
- W1986173845 cites W1969898114 @default.
- W1986173845 cites W1974733477 @default.
- W1986173845 cites W1975122853 @default.
- W1986173845 cites W1979630985 @default.
- W1986173845 cites W1984150038 @default.
- W1986173845 cites W1987002413 @default.
- W1986173845 cites W1987982858 @default.
- W1986173845 cites W1987984630 @default.
- W1986173845 cites W1988425276 @default.
- W1986173845 cites W1988500121 @default.
- W1986173845 cites W1989521996 @default.
- W1986173845 cites W1990701251 @default.
- W1986173845 cites W1991022617 @default.
- W1986173845 cites W1993186321 @default.
- W1986173845 cites W1993496957 @default.
- W1986173845 cites W1995778111 @default.
- W1986173845 cites W1996252527 @default.
- W1986173845 cites W1998161495 @default.
- W1986173845 cites W1999794948 @default.
- W1986173845 cites W2000703662 @default.
- W1986173845 cites W2003579943 @default.
- W1986173845 cites W2006309458 @default.
- W1986173845 cites W2010763948 @default.
- W1986173845 cites W2011971307 @default.
- W1986173845 cites W2021770060 @default.
- W1986173845 cites W2022103755 @default.
- W1986173845 cites W2022687771 @default.
- W1986173845 cites W2023645777 @default.
- W1986173845 cites W2027165660 @default.
- W1986173845 cites W2027545702 @default.
- W1986173845 cites W2029120199 @default.
- W1986173845 cites W2029323175 @default.
- W1986173845 cites W2030576387 @default.
- W1986173845 cites W2037686553 @default.
- W1986173845 cites W2039881321 @default.
- W1986173845 cites W2040236561 @default.
- W1986173845 cites W2042997260 @default.
- W1986173845 cites W2043781110 @default.
- W1986173845 cites W2044193462 @default.
- W1986173845 cites W2046714103 @default.
- W1986173845 cites W2048013497 @default.
- W1986173845 cites W2048699176 @default.
- W1986173845 cites W2049294752 @default.
- W1986173845 cites W2050706347 @default.
- W1986173845 cites W2051112926 @default.
- W1986173845 cites W2051761287 @default.
- W1986173845 cites W2057318017 @default.
- W1986173845 cites W2057627174 @default.
- W1986173845 cites W2058524504 @default.
- W1986173845 cites W2062153657 @default.
- W1986173845 cites W2062405322 @default.
- W1986173845 cites W2065447790 @default.
- W1986173845 cites W2067301997 @default.
- W1986173845 cites W2067837286 @default.
- W1986173845 cites W2072697431 @default.
- W1986173845 cites W2078887917 @default.
- W1986173845 cites W2078893995 @default.
- W1986173845 cites W2079724990 @default.
- W1986173845 cites W2086617513 @default.
- W1986173845 cites W2088555721 @default.
- W1986173845 cites W2091403605 @default.
- W1986173845 cites W2093378175 @default.
- W1986173845 cites W2093579074 @default.
- W1986173845 cites W2096100733 @default.
- W1986173845 cites W2101177020 @default.
- W1986173845 cites W2106239124 @default.
- W1986173845 cites W2107020066 @default.
- W1986173845 cites W2107085672 @default.
- W1986173845 cites W2107272456 @default.
- W1986173845 cites W2109666873 @default.
- W1986173845 cites W2112930049 @default.
- W1986173845 cites W2114579885 @default.
- W1986173845 cites W2117084310 @default.
- W1986173845 cites W2119303435 @default.
- W1986173845 cites W2122153421 @default.
- W1986173845 cites W2122815970 @default.
- W1986173845 cites W2122973751 @default.
- W1986173845 cites W2126153046 @default.
- W1986173845 cites W2128252769 @default.
- W1986173845 cites W2129993409 @default.
- W1986173845 cites W2131245007 @default.
- W1986173845 cites W2136652080 @default.
- W1986173845 cites W2142347139 @default.
- W1986173845 cites W2142684817 @default.
- W1986173845 cites W2145653235 @default.
- W1986173845 cites W2147126871 @default.
- W1986173845 cites W2150742206 @default.