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- W1986174380 abstract "In humans UV-induced cyclobutane thymine dimers are excised by the joint action of six repair factors, RPA, XPA, XPC, TFIIH, XPG, and XPF.ERCC1. Yet, in vitro assays show that none of these six factors is capable of detectably discriminating thymine dimer-containing DNA from undamaged DNA. We show how two elementary principles in macromolecular recognition, (1). cooperativity and (2). kinetic proofreading, are utilized to confer specificity to the repair system where none exists at the individual repair factor level and enable human cells to excise thymine dimers with a physiologically relevant specificity and at a biologically acceptable rate." @default.
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- W1986174380 date "2004-02-01" @default.
- W1986174380 modified "2023-10-18" @default.
- W1986174380 title "Thermodynamic Cooperativity and Kinetic Proofreading in DNA Damage Recognition and Repair" @default.
- W1986174380 doi "https://doi.org/10.4161/cc.3.2.645" @default.
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