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- W1986175023 abstract "Guntheroth et al 1 Guntheroth WC Luchtel DL Kawabari I. Functional implications of the pulmonary microcirculation. Chest. 1992; 101: 1131-1134 Abstract Full Text Full Text PDF Scopus (8) Google Scholar presented two striking scanning electron micrographs of rubber casts of the rat pulmonary microvasculature and drew a number of conclusions from them, with which they sought to discredit our analysis 2 Fung YC Sobin SS. Theory of sheet flow in lung alveoli. J Appl Physiol. 1969; 26: 472-488 PubMed Google Scholar , 3 Sobin SS Tremer HM Fung YC. Morphometric basis of the sheet-flow concept of the pulmonary alveolar microcirculation in the cat. Circ Res. 1970; 26: 397-414 Crossref PubMed Scopus (68) Google Scholar , 4 Sobin SS Fung YC Tremer HM Rosenquist TH. Elasticity of the pulmonary alveolar microvascular sheet in the cat. Circ Res. 1972; 30: 440-490 Crossref PubMed Scopus (61) Google Scholar , 5 Fung YC Sobin SS. Elasticity of the pulmonary alveolar sheet. Circ Res. 1972; 30: 451-469 Crossref PubMed Scopus (75) Google Scholar , 6 Fung YC Sobin SS. Pulmonary alveolar blood flow. Circ Res. 1972; 30: 470-490 Crossref PubMed Scopus (82) Google Scholar , 7 Fung YC. Fluid in the interstitial space of the pulmonary alveolar sheet. Microvasc Res. 1974; 7: 89-113 Crossref PubMed Scopus (11) Google Scholar , 8 Fung YC Sobin SS. Pulmonary alveolar blood flow. in: West JB Bioengineering aspects of the lung. M Dekker, New York1977: 270 Google Scholar , 9 Fung YC Yen RT. A new theory of pulmonary blood flow in zone 2 condition. J Appl Physiol. 1986; 60: 1638-1650 PubMed Google Scholar of pulmonary blood flow. Their main conclusions were: (1)The alveolar microcirculation is composed of a tight meshwork of intersecting tubules in two layers, on either side of the alveolar septum, with frequent interconnecting branches. (2)The tubular length is greater than the diameter; therefore, Poiseuille's law would not be invalid if applied to this circulation. (3)Weibel's 10 Weibel ER. Morphometry of the human lung. Springer-Verlag, Berlin1963: 78 Google Scholar hexagonal tubular network model and Sobin and Fung's 2 Fung YC Sobin SS. Theory of sheet flow in lung alveoli. J Appl Physiol. 1969; 26: 472-488 PubMed Google Scholar , 3 Sobin SS Tremer HM Fung YC. Morphometric basis of the sheet-flow concept of the pulmonary alveolar microcirculation in the cat. Circ Res. 1970; 26: 397-414 Crossref PubMed Scopus (68) Google Scholar , 4 Sobin SS Fung YC Tremer HM Rosenquist TH. Elasticity of the pulmonary alveolar microvascular sheet in the cat. Circ Res. 1972; 30: 440-490 Crossref PubMed Scopus (61) Google Scholar , 5 Fung YC Sobin SS. Elasticity of the pulmonary alveolar sheet. Circ Res. 1972; 30: 451-469 Crossref PubMed Scopus (75) Google Scholar , 6 Fung YC Sobin SS. Pulmonary alveolar blood flow. Circ Res. 1972; 30: 470-490 Crossref PubMed Scopus (82) Google Scholar , 7 Fung YC. Fluid in the interstitial space of the pulmonary alveolar sheet. Microvasc Res. 1974; 7: 89-113 Crossref PubMed Scopus (11) Google Scholar , 8 Fung YC Sobin SS. Pulmonary alveolar blood flow. in: West JB Bioengineering aspects of the lung. M Dekker, New York1977: 270 Google Scholar , 9 Fung YC Yen RT. A new theory of pulmonary blood flow in zone 2 condition. J Appl Physiol. 1986; 60: 1638-1650 PubMed Google Scholar sheet flow model are both contradicted by scanning electron micrographs of Guntheroth et al. 1 Guntheroth WC Luchtel DL Kawabari I. Functional implications of the pulmonary microcirculation. Chest. 1992; 101: 1131-1134 Abstract Full Text Full Text PDF Scopus (8) Google Scholar (4)The capillaries on the pleural surfaces and peribronchial spaces are low density, long tubular meshwork, „unequivocally composed of conventional capillaries.” The sheet-flow model cannot be applied to networks of lower density. (5)Guntheroth et al 1 Guntheroth WC Luchtel DL Kawabari I. Functional implications of the pulmonary microcirculation. Chest. 1992; 101: 1131-1134 Abstract Full Text Full Text PDF Scopus (8) Google Scholar tell the reader that we have either said or implied the following, which we did not: (a)The sheet thickness (h) was linearly related to distending pressure all the way so that the sheet will not collapse in zone 1 condition. The smallest thickness „h” is 4.3 µm. (b)The elastic fibers radiate from focal points or posts, and are not distributed randomly in a way that almost ignores the posts. (c)All of the capillaries are „at the same distance apart,” or all posts have uniform diameters. (d)The sheet-and-post theory is not compatible with experimental data for three zones relating capillary pressures to alveolar pressure. (e)The sheet flow model will exclude recruitment. (f)Structural support of interalveolar septa interferes with diffusion. (g)Sheet flow will prevent pulsatile flow and cannot transmit pulmonary arterial pulse to the pulmonary vein." @default.
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- W1986175023 date "1992-04-01" @default.
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- W1986175023 title "Response to Challenge to the Sobin-Fung Approach to the Study of Pulmonary Microcirculation" @default.
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- W1986175023 doi "https://doi.org/10.1378/chest.101.4.1135" @default.
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