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• W1986177755 abstract "Annals of the New York Academy of SciencesVolume 531, Issue 1 p. 108-122 Intraspinal Analgesic Infusion by Implanted Pumpa DENNIS W. COOMBS, DENNIS W. COOMBS Department of Anesthesiology Dartmouth-Hitchcock Medical Center Hanover, New Hampshire 03756Search for more papers by this author DENNIS W. COOMBS, DENNIS W. COOMBS Department of Anesthesiology Dartmouth-Hitchcock Medical Center Hanover, New Hampshire 03756Search for more papers by this author First published: June 1988 https://doi.org/10.1111/j.1749-6632.1988.tb31817.xCitations: 24 a Supported by the National Cancer Institute, Public Health Service Grant CA33865, Infusaid Corporation, the Robert Osgood, Jr. Memorial Fund, the Kingsbury Fund, and the Anesthesia Research Fund of the Hitchcock Clinic. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Coombs, D. W., R. L. Saunders, M. S. Gaylor, M. Pageau, M. G. Leith & C. Shaiberger. 1981. Continuous epidural analgesia via implanted morphine reservoir. Lancet 2: 425–426. 2 Onofrio, B. M., T. L. Yaksh & P. G. Arnold. 1981. Continuous low-dose intrathecal morphine administered in the treatment of chronic pain of malignant origin. Mayo Clin. Proc. 56: 516–520. 3 Coombs, D. W., R. L. Saunders, M. Gaylor & M. Pageau. 1982. Epidural narcotic infusion reservoir: implantation technique and efficacy. Anesthesiology 56: 469–473. 4 Penn, R. D., J. A. Paice, W. Gottschalk & A. Ivankovich. 1984. Cancer pain relief using chronic morphine infusion. J. Neurosurg. 61: 302–306. 5 Krames, E., J. Gershow, A. Glassberg, T. Kenefick, A. Lyons, P. Taylor & D. Wilkie. 1985. Continuous infusion of spinally administered narcotics for the relief of pain due to malignant disorders. Cancer 56: 696–702. 6 Hadley, M. & A. Shettner. 1986. Intrathecal opiate administration for analgesia. Contemp. Neurosurg. 8: 1–5. 7 Brazenor, G. A. 1987. Long term intrathecal administration of morphineA comparison of bolus injection via reservoir with continuous infusion by implanted pump. Neurosurgery 21: 484–491. 8 Coombs, D. W. 1985. New approaches to chronic pain therapy. Semin. Anesth. 4: 287–299. 9 Yaksh, T. L. 1981. Spinal opiate analgesia: characteristics and principles of action. Pain 11: 293–346. 10 Cousins, M. J. & L. E. Mather. 1984. Intrathecal and epidural administration of opiates. (Review). Anesthesiology 61: 276–310. 11 Yeung, J. L. & T. A. Rudy. 1980. Multiplicative interaction between narcotic agonists expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intraventricular injections of morphine. J. Pharmacol. Exp. Ther. 215: 633–642. 12 Foley, K. M. 1985. The treatment of cancer pain. N. Engl. J. Med. 313: 84–95. 13 Houde, R. W. 1985. Controlled release morphine preparations. In Management of Cancer Pain. Syllabus of the Post-Graduate Course, Memorial Sloan-Kettering Cancer Center, November 14–16. 177–180. Memorial Sloan-Kettering, New York , NY. 14 Nordberg, G. 1984. Pharmacokinetic aspects of spinal morphine analgesia. Acta Anaesth. Scand. 28(Suppl. 79): 1–38. 15 Zenz, M. 1984. Epidural opiates for the treatment of cancer pain. In Recent Results in Cancer Research. M. Zimmerman, P. Drugs & G. Wagner, Eds. Vol. 89: 107–115. Springer Verlag. Heidelberg . 16 Eriksen, J. & H. B. Andersen. 1984. Pain treatment on long term basis using extradural opiates. Pain (Suppl. 2): S335. 17 Jorgensen, B. C., H. B. Andersen & A. Engquist. 1981. CSF and plasma morphine after epidural and intrathecal application. Anesthesiology 55: 714–715. 18 Coombs, D. W., J. D. Fratkin, F. A. Meier, D. W. Nierenberg & R. L. Sanders. 1985. Neuropathologic lesions and CSF morphine concentrations during chronic continuous intraspinal morphine infusion: a clinical and post mortem study. Pain 22: 337–351. 19 Yaksh, T. L. & B. M. Onofrio. 1987. Retrospective consideration of the doses of morphine given intrathecally by chronic infusion in 163 patients by 19 physicians. Pain 31(2): 211–223. 20 Coombs, D. W. 1985. Continuous intraspinal morphine analgesia for relief of cancer pain. Monograph for Intermedics Infusaid, Inc. 1–29. Shea Bros. Cambridge, MA. 21 Coombs, D. W. 1986. Management of chronic pain by epidural and intrathecal opioids: newer drugs and delivery systems. U. H. Sjostrand & N. Rawal, Eds. International Anesthesiology Clinics. Vol. 24: No. 2. Little Brown. Boston , MA . 22 Waldman, S. & D. W. Coombs. 1988. Selection of implantable narcotic delivery systems. In preparation. 23 Penn, R. & J. Paice. 1987. Chronic intrathecal morphine for intractable pain. J. Neurosurg. 67: 182–186. 24 Coombs, D. W., H. L. Maurer, R. L. Saunders & M. Gaylor. 1984. Outcomes and complications of continuous intraspinal narcotic analgesia for cancer pain control. J. Clin. Oncol. 2: 1414–1420. 25 Coombs, D. W. & J. D. Fratkin. 1987. Neurotoxicology of spinal agents. Anesthesiology 66: 724–726. 26 Rodan, B. A., F. L. Cohen, W. L. Bean & S. N. Martyak. 1985. Fibrous mass complicating epidural morphine administration in the treatment of chronic pain of malignant origin. Neurosurgery 16: 68–70. 27 Coombs, D. W., R. L. Saunders, L. H. Maurer, L. Jensen & T. Stukel. 1988. Double-blind randomized controlled clinical trial of conventional systemic narcotic therapy versus continuous intrathecal morphine infusion for control of intractable cancer pain. In preparation. 28 Coombs, D. W., R. L. Saunders, R. Harbaugh, M. S. Gaylor, M. Pageau & T. Colton. 1983. Relief of continuous chronic pain by intraspinal narcotics infusion via an implanted reservoir. J. Am. Med. Assoc. 250: 2336–2339. 29 Yaksh, T. L. & B. M. Onofrio. Personal communication. 30 Onofrio, B. M. & T. L. Yaksh. 1983. Intrathecal delta receptor ligand produces analgesia in man. Lancet 1: 1386–1387. 31 Bay, J. & R. Harding. 1986. Personal communication—proceedings of pain symposium at Cleveland Clinic. May 1986. Cleveland , OH . 32 Herman, R. M., D. W. Coombs, R. L. Saunders & M. C. Wainberg. 1987. Alterations and micturation reflexes and spasticity following continual intrathecal infusion of morphine in human subjects with spinal cord lesions. Society for Neuroscience, 17th Annual Meeting. November 16–21. Abstracts Vol. 13: 361.3. 33 Walsh, T. D. 1984. Oral morphine in chronic cancer pain. Pain 18: 1–11. 34 Arner, S. & B. Arner. 1985. Differential effects of epidural morphine in the treatment of cancer-related pain. Acta Anaesthesiol. Scand. 29: 32–36. 35 Schmauss, C. & T. L. Yaksh. 1983. In vivo studies on spinal opiate receptor systems mediating antinociception: II. Pharmacological profiles suggesting a differential association of mu, delta, and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat. J. Pharmacol. Exp. Ther. 228: 1–12. 36 Yaksh, T. L. 1983. In vivo studies on spinal opiate receptor systems mediating antinociception. I: mu and delta receptor profiles in the primate. J. Pharmacol. Exp. Ther. 226: 303–316. 37 Carl, P., M. E. Crawford, O. Ravlo & V. Bach. 1986. Long term treatment with epidural opioids. Anaesthesia 41: 32–38. 38 Coombs, D. W., R. L. Saunders, D. LaChance, S. Savage, T. S. Ragnarsson & L. E. Jensen. 1985. Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphineA representative case and review. Anesthesiology 62: 358–363. 39 Coombs, D. W., R. L. Saunders, J. D. Fratkin, L. E. Jensen & C. A. Murphy. 1986. Continuous intrathecal hydromorphone and clonidine for intractable cancer pain. J. Neurosurg. 64: 890–894. 40 Coombs, D. W., M. Pageau, R. L. Saunders & W. T. Mroz. 1982. Intraspinal narcotic tolerance: preliminary experience with bupivacaine Hcl infusion via implanted infusion device. Int. J. Artif. Org. 5: 379–382. 41 Yaksh, T. L. 1985. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav. 22: 845–858. 42 Yaksh, T. L. & S. V. R. Reddy. 1981. Studies in the primate on the analgesic effects associated with intrathecal actions of opiates, adrenergic agonists, and baclofen. Anesthesiology 54: 451–467. 43 Gordh, T. E., S. Ekman & A. Lagerstedt. 1984. Evaluation of possible spinal neurotoxicity of clonidine. Upsala J. Med. Sci. 89: 266–273. 44 Coombs, D. W., C. Allen, F. Meier & J. Fratkin. 1984. Chronic intraspinal clonidine in sheep. Reg. Anesth. 9: 47–48. 45 Eisenach, J. C., J. C. Rose, D. M. Dewan & J. Angelo. 1987. Epidural clonidine produces analgesia but not hypotension in sheep. Anesthesiology 66: 496–501. 46 Coombs, D. W., L. Jensen & D. Thron. Pharmacokinetics of bolus intrathecal clonidine in man. Unpublished observations 198485. 47 Fratkin, J., R. L. Saunders & D. W. Coombs. Spinal cord and leptomeningeal histopathology following chronic intraspinal clonidine infusion in man (unpublished observation). 48 Moulin, D. E., M. B. Max, R. F. Kaiko, C. S. Inturrisi, J. Maggard, T. M. Yaksh & K. M. Foley. 1985. The analgesic efficacy of intrathecal (IT) D-ala2-D-leus-enkephalin (DADLE) in cancer patients with chronic pain. Pain 23: 213–221. 49 Krames, E. S., D. J. Wilkie & J. Gershow. 1986. Intrathecal D-ala2-D-Leu5-enkephalin (DADL) restores analgesia in a patient analgetically tolerant to intrathecal morphine sulfate. Pain 24: 205–209. 50 Meynadier, J., J. Chrubasik, M. Dubar & E. Wünsch. 1985. Intrathecal somatostatin in two terminally ill patients. Pain 23: 9–12. 51 Kroin, J. S., R. J. McCarthy, R. D. Penn, J. M. Kerns & A. D. Ivankovich. 1987. The effect of chronic subarachnoid bupivacaine infusion in dogs. Anesthesiology 66: 737–742. 52 Coombs, D. W. 1987. Continuous intraspinal narcotics for cancer pain in cervicothoracic dermatomes. Reg. Anesth. (ASRA 12th Annual Meeting Abstracts) 12: 27. 53 Yaksh, T. L., G. L. Harty & B. M. Onofrio. 1986. High doses of spinal morphine produce a nonopiate receptor mediated hyperalgesia: clinical and theoretic implications. Anesthesiology 64: 590–597. Citing Literature Volume531, Issue1Neurological Applications of Implanted Drug PumpsJune 1988Pages 108-122 ReferencesRelatedInformation" @default.
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