FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986184477> ?p ?o ?g. }

• W1986184477 endingPage "622" @default.
• W1986184477 startingPage "615" @default.
• W1986184477 abstract "Insulin autoantibodies (IAA) are early markers of prediabetic autoimmunity. As transient and fluctuating IAA positivity are common among young children, distinguishing non-progressive IAA from destruction-related IAA is essential when preventive measures are considered. We tested whether children progressing rapidly to type 1 diabetes (progressors) are characterized by a higher prediabetic IAA affinity than IAA-positive children remaining unaffected or progressing more slowly to diabetes (non-progressors), and whether IAA affinity increases towards diagnosis.Finnish children with HLA-conferred diabetes susceptibility were observed from birth for diabetes-associated autoantibodies and progression to overt type 1 diabetes. IAA levels and affinities of the first IAA-positive prediabetic samples and samples obtained closest to the diagnosis in 64 progressors were compared with corresponding values in 64 matched IAA-positive non-progressors.The median age at diagnosis was 3.9 years in progressors and the median follow-up time 7.6 years among unaffected subjects. In the first samples the median IAA affinity was 1.4 x 10(10) L/mol in both groups (p = 0.33), while at the second sampling it was 1.1 x 10(10) L/mol in progressors and 1.2 x 10(10) L/mol in unaffected subjects (p = 0.46). No changes in affinity levels were observed (p = 0.33 and p = 0.84, respectively). IAA titers increased towards diagnosis among progressors (from a median of 13.6 to 20.1 relative units; p = 0.02).Among young IAA-positive children with HLA-conferred disease susceptibility IAA affinity failed to distinguish rapid progressors from slowly or non-progressing subjects. In relation to IAA affinity, no maturation of the humoral immune response was observed over time from seroconversion to diagnosis." @default.
• W1986184477 created "2016-06-24" @default.
• W1986184477 creator A5000141478 @default.
• W1986184477 creator A5000991422 @default.
• W1986184477 creator A5001640598 @default.
• W1986184477 creator A5024634851 @default.
• W1986184477 creator A5031201794 @default.
• W1986184477 creator A5064931375 @default.
• W1986184477 creator A5066618511 @default.
• W1986184477 creator A5075640419 @default.
• W1986184477 creator A5088970962 @default.
• W1986184477 creator A5089367639 @default.
• W1986184477 creator A5089873556 @default.
• W1986184477 date "2009-07-27" @default.
• W1986184477 modified "2023-10-12" @default.
• W1986184477 title "Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility" @default.
• W1986184477 cites W1989291032 @default.
• W1986184477 cites W2002761055 @default.
• W1986184477 cites W2003287241 @default.
• W1986184477 cites W2009802964 @default.
• W1986184477 cites W2019972832 @default.
• W1986184477 cites W2024286357 @default.
• W1986184477 cites W2032644834 @default.
• W1986184477 cites W2036993603 @default.
• W1986184477 cites W2043518556 @default.
• W1986184477 cites W2048685756 @default.
• W1986184477 cites W2052938595 @default.
• W1986184477 cites W2057159752 @default.
• W1986184477 cites W2060618131 @default.
• W1986184477 cites W2083754730 @default.
• W1986184477 cites W2084710830 @default.
• W1986184477 cites W2090742005 @default.
• W1986184477 cites W2113093880 @default.
• W1986184477 cites W2123412381 @default.
• W1986184477 cites W2134686606 @default.
• W1986184477 cites W2136015010 @default.
• W1986184477 cites W2144361039 @default.
• W1986184477 cites W2157440365 @default.
• W1986184477 cites W2776280 @default.
• W1986184477 cites W4246356838 @default.
• W1986184477 cites W4255437868 @default.
• W1986184477 cites W614574849 @default.
• W1986184477 doi "https://doi.org/10.1002/dmrr.998" @default.
• W1986184477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19637309" @default.
• W1986184477 hasPublicationYear "2009" @default.
• W1986184477 type Work @default.
• W1986184477 sameAs 1986184477 @default.
• W1986184477 citedByCount "24" @default.
• W1986184477 countsByYear W19861844772012 @default.
• W1986184477 countsByYear W19861844772013 @default.
• W1986184477 countsByYear W19861844772014 @default.
• W1986184477 countsByYear W19861844772015 @default.
• W1986184477 countsByYear W19861844772016 @default.
• W1986184477 countsByYear W19861844772017 @default.
• W1986184477 countsByYear W19861844772020 @default.
• W1986184477 countsByYear W19861844772021 @default.
• W1986184477 countsByYear W19861844772022 @default.
• W1986184477 countsByYear W19861844772023 @default.
• W1986184477 crossrefType "journal-article" @default.
• W1986184477 hasAuthorship W1986184477A5000141478 @default.
• W1986184477 hasAuthorship W1986184477A5000991422 @default.
• W1986184477 hasAuthorship W1986184477A5001640598 @default.
• W1986184477 hasAuthorship W1986184477A5024634851 @default.
• W1986184477 hasAuthorship W1986184477A5031201794 @default.
• W1986184477 hasAuthorship W1986184477A5064931375 @default.
• W1986184477 hasAuthorship W1986184477A5066618511 @default.
• W1986184477 hasAuthorship W1986184477A5075640419 @default.
• W1986184477 hasAuthorship W1986184477A5088970962 @default.
• W1986184477 hasAuthorship W1986184477A5089367639 @default.
• W1986184477 hasAuthorship W1986184477A5089873556 @default.
• W1986184477 hasConcept C126322002 @default.
• W1986184477 hasConcept C134018914 @default.
• W1986184477 hasConcept C147483822 @default.
• W1986184477 hasConcept C159654299 @default.
• W1986184477 hasConcept C163764329 @default.
• W1986184477 hasConcept C188280979 @default.
• W1986184477 hasConcept C203014093 @default.
• W1986184477 hasConcept C2777180221 @default.
• W1986184477 hasConcept C2779134260 @default.
• W1986184477 hasConcept C2779306644 @default.
• W1986184477 hasConcept C2780130043 @default.
• W1986184477 hasConcept C2781232474 @default.
• W1986184477 hasConcept C32611913 @default.
• W1986184477 hasConcept C555293320 @default.
• W1986184477 hasConcept C71924100 @default.
• W1986184477 hasConceptScore W1986184477C126322002 @default.
• W1986184477 hasConceptScore W1986184477C134018914 @default.
• W1986184477 hasConceptScore W1986184477C147483822 @default.
• W1986184477 hasConceptScore W1986184477C159654299 @default.
• W1986184477 hasConceptScore W1986184477C163764329 @default.
• W1986184477 hasConceptScore W1986184477C188280979 @default.
• W1986184477 hasConceptScore W1986184477C203014093 @default.
• W1986184477 hasConceptScore W1986184477C2777180221 @default.
• W1986184477 hasConceptScore W1986184477C2779134260 @default.
• W1986184477 hasConceptScore W1986184477C2779306644 @default.
• W1986184477 hasConceptScore W1986184477C2780130043 @default.
• W1986184477 hasConceptScore W1986184477C2781232474 @default.
• W1986184477 hasConceptScore W1986184477C32611913 @default.

• next