FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986205743> ?p ?o ?g. }

• W1986205743 endingPage "1116" @default.
• W1986205743 startingPage "1111" @default.
• W1986205743 abstract "Removal of the dietary wheat protein gluten protects against autoimmune diabetes in animal models. Furthermore, elimination of dietary gluten reduces the frequency of type 1 diabetes in patients with celiac disease. Herein we test the hypothesis that gluten is the driving antigen for type 1 diabetes-associated islet autoimmunity.Seven autoantibody-positive, first-degree relatives of patients with type 1 diabetes were placed on a gluten-free diet for 12 months followed by gluten reexposure for 12 months. Gliadin antibodies as well as the diabetes-related antibodies insulin autoantibody (IAA), GAD antibody (GADA), and tyrosin phosphatase IA2 antibody (IA-2A) were measured every 3 months; oral glucose tolerance tests were performed every 6 months. Changes in autoantibody titers were compared with those observed in a matched historical cohort.A reduction in IgG gliadin antibody titers was observed during the gluten-free period, but titers of diabetes-associated autoantibodies changed independently of gluten exposure. Type 1 diabetes-associated islet autoantibody levels at the end of the gluten-free diet period were not significantly different from those before commencement of the diet (P = 0.2) or at the end of the gluten reexposure period (P = 0.4). Changes in individual subjects were identified, but no differences were noted between the gluten-free and the gluten re-exposure periods, and the changes were similar to those observed in the historical control cohort (P = 1.0). Major titer reductions (>50%) in the gluten-free period were observed in only one subject for all antibodies. Type 1 diabetes developed in this subject and in a second subject during the gluten reexposure period.The findings do not support the hypothesis that gluten is a driving antigen in type 1 diabetes." @default.
• W1986205743 created "2016-06-24" @default.
• W1986205743 creator A5018491022 @default.
• W1986205743 creator A5026837875 @default.
• W1986205743 creator A5048098090 @default.
• W1986205743 creator A5082377056 @default.
• W1986205743 date "2002-07-01" @default.
• W1986205743 modified "2023-10-13" @default.
• W1986205743 title "Elimination of Dietary Gluten Does Not Reduce Titers of Type 1 Diabetes-Associated Autoantibodies in High-Risk Subjects" @default.
• W1986205743 cites W1984981998 @default.
• W1986205743 cites W1986455427 @default.
• W1986205743 cites W1987433373 @default.
• W1986205743 cites W2014071845 @default.
• W1986205743 cites W2044663713 @default.
• W1986205743 cites W2070314271 @default.
• W1986205743 cites W2074906766 @default.
• W1986205743 cites W2091765481 @default.
• W1986205743 cites W2114047926 @default.
• W1986205743 cites W2123412381 @default.
• W1986205743 cites W2140103652 @default.
• W1986205743 cites W2147738130 @default.
• W1986205743 cites W2163626160 @default.
• W1986205743 cites W2170407850 @default.
• W1986205743 cites W4239268488 @default.
• W1986205743 cites W49062931 @default.
• W1986205743 doi "https://doi.org/10.2337/diacare.25.7.1111" @default.
• W1986205743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12087006" @default.
• W1986205743 hasPublicationYear "2002" @default.
• W1986205743 type Work @default.
• W1986205743 sameAs 1986205743 @default.
• W1986205743 citedByCount "63" @default.
• W1986205743 countsByYear W19862057432012 @default.
• W1986205743 countsByYear W19862057432013 @default.
• W1986205743 countsByYear W19862057432014 @default.
• W1986205743 countsByYear W19862057432015 @default.
• W1986205743 countsByYear W19862057432016 @default.
• W1986205743 countsByYear W19862057432017 @default.
• W1986205743 countsByYear W19862057432018 @default.
• W1986205743 countsByYear W19862057432019 @default.
• W1986205743 countsByYear W19862057432020 @default.
• W1986205743 countsByYear W19862057432022 @default.
• W1986205743 countsByYear W19862057432023 @default.
• W1986205743 crossrefType "journal-article" @default.
• W1986205743 hasAuthorship W1986205743A5018491022 @default.
• W1986205743 hasAuthorship W1986205743A5026837875 @default.
• W1986205743 hasAuthorship W1986205743A5048098090 @default.
• W1986205743 hasAuthorship W1986205743A5082377056 @default.
• W1986205743 hasBestOaLocation W19862057431 @default.
• W1986205743 hasConcept C126322002 @default.
• W1986205743 hasConcept C134018914 @default.
• W1986205743 hasConcept C142724271 @default.
• W1986205743 hasConcept C159654299 @default.
• W1986205743 hasConcept C163764329 @default.
• W1986205743 hasConcept C203014093 @default.
• W1986205743 hasConcept C22889606 @default.
• W1986205743 hasConcept C2776336767 @default.
• W1986205743 hasConcept C2777180221 @default.
• W1986205743 hasConcept C2779134260 @default.
• W1986205743 hasConcept C2780092158 @default.
• W1986205743 hasConcept C2780130043 @default.
• W1986205743 hasConcept C2780349322 @default.
• W1986205743 hasConcept C2781232474 @default.
• W1986205743 hasConcept C3019118998 @default.
• W1986205743 hasConcept C32611913 @default.
• W1986205743 hasConcept C555293320 @default.
• W1986205743 hasConcept C71924100 @default.
• W1986205743 hasConceptScore W1986205743C126322002 @default.
• W1986205743 hasConceptScore W1986205743C134018914 @default.
• W1986205743 hasConceptScore W1986205743C142724271 @default.
• W1986205743 hasConceptScore W1986205743C159654299 @default.
• W1986205743 hasConceptScore W1986205743C163764329 @default.
• W1986205743 hasConceptScore W1986205743C203014093 @default.
• W1986205743 hasConceptScore W1986205743C22889606 @default.
• W1986205743 hasConceptScore W1986205743C2776336767 @default.
• W1986205743 hasConceptScore W1986205743C2777180221 @default.
• W1986205743 hasConceptScore W1986205743C2779134260 @default.
• W1986205743 hasConceptScore W1986205743C2780092158 @default.
• W1986205743 hasConceptScore W1986205743C2780130043 @default.
• W1986205743 hasConceptScore W1986205743C2780349322 @default.
• W1986205743 hasConceptScore W1986205743C2781232474 @default.
• W1986205743 hasConceptScore W1986205743C3019118998 @default.
• W1986205743 hasConceptScore W1986205743C32611913 @default.
• W1986205743 hasConceptScore W1986205743C555293320 @default.
• W1986205743 hasConceptScore W1986205743C71924100 @default.
• W1986205743 hasIssue "7" @default.
• W1986205743 hasLocation W19862057431 @default.
• W1986205743 hasLocation W19862057432 @default.
• W1986205743 hasOpenAccess W1986205743 @default.
• W1986205743 hasPrimaryLocation W19862057431 @default.
• W1986205743 hasRelatedWork W131205977 @default.
• W1986205743 hasRelatedWork W1967549159 @default.
• W1986205743 hasRelatedWork W1985092484 @default.
• W1986205743 hasRelatedWork W2031780954 @default.
• W1986205743 hasRelatedWork W2058427584 @default.
• W1986205743 hasRelatedWork W2084210914 @default.
• W1986205743 hasRelatedWork W2161024743 @default.
• W1986205743 hasRelatedWork W3150484808 @default.
• W1986205743 hasRelatedWork W323336631 @default.

• next