FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986215516> ?p ?o ?g. }

• W1986215516 endingPage "1260" @default.
• W1986215516 startingPage "1252" @default.
• W1986215516 abstract "Abstract Matrix metalloproteinases (MMPs) are capable of processing certain components of bone tissue, including type 1 collagen, a determinant of the biomechanical properties of bone tissue, and they are expressed by osteoclasts and osteoblasts. Therefore, we posit that MMP activity can affect the ability of bone to resist fracture. To explore this possibility, we determined the architectural, compositional, and biomechanical properties of bones from wild‐type (WT), Mmp2 −/− , and Mmp9 −/− female mice at 16 weeks of age. MMP‐2 and MMP‐9 have similar substrates but are expressed primarily by osteoblasts and osteoclasts, respectively. Analysis of the trabecular compartment of the tibia metaphysis by micro–computed tomography (µCT) revealed that these MMPs influence trabecular architecture, not volume. Interestingly, the loss of MMP‐9 improved the connectivity density of the trabeculae, whereas the loss of MMP‐2 reduced this parameter. Similar differential effects in architecture were observed in the L 5 vertebra, but bone volume fraction was lower for both Mmp2 −/− and Mmp9 −/− mice than for WT mice. The mineralization density and mineral‐to‐collagen ratio, as determined by µCT and Raman microspectroscopy, were lower in the Mmp2 −/− bones than in WT control bones. Whole‐bone strength, as determined by three‐point bending or compression testing, and tissue‐level modulus and hardness, as determined by nanoindentation, were less for Mmp2 −/− than for WT bones. In contrast, the Mmp9 −/− femurs were less tough with lower postyield deflection (more brittle) than the WT femurs. Taken together, this information reveals that MMPs play a complex role in maintaining bone integrity, with the cell type that expresses the MMP likely being a contributing factor to how the enzyme affects bone quality. © 2011 American Society for Bone and Mineral Research." @default.
• W1986215516 created "2016-06-24" @default.
• W1986215516 creator A5002325815 @default.
• W1986215516 creator A5005942374 @default.
• W1986215516 creator A5014023359 @default.
• W1986215516 creator A5014645084 @default.
• W1986215516 creator A5015533587 @default.
• W1986215516 creator A5017780140 @default.
• W1986215516 creator A5023756240 @default.
• W1986215516 creator A5028500843 @default.
• W1986215516 creator A5029437522 @default.
• W1986215516 creator A5070210677 @default.
• W1986215516 date "2011-05-24" @default.
• W1986215516 modified "2023-10-12" @default.
• W1986215516 title "Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone" @default.
• W1986215516 cites W1757602702 @default.
• W1986215516 cites W1953148896 @default.
• W1986215516 cites W1966170741 @default.
• W1986215516 cites W1975522291 @default.
• W1986215516 cites W1978968292 @default.
• W1986215516 cites W1993612260 @default.
• W1986215516 cites W1998111806 @default.
• W1986215516 cites W2000983409 @default.
• W1986215516 cites W2001431467 @default.
• W1986215516 cites W2005057827 @default.
• W1986215516 cites W2005601953 @default.
• W1986215516 cites W2005603603 @default.
• W1986215516 cites W2011353372 @default.
• W1986215516 cites W2016411107 @default.
• W1986215516 cites W2019031770 @default.
• W1986215516 cites W2023407069 @default.
• W1986215516 cites W2024602261 @default.
• W1986215516 cites W2025258577 @default.
• W1986215516 cites W2030851434 @default.
• W1986215516 cites W2035532578 @default.
• W1986215516 cites W2039707379 @default.
• W1986215516 cites W2041057131 @default.
• W1986215516 cites W2051166244 @default.
• W1986215516 cites W2053591982 @default.
• W1986215516 cites W2067519034 @default.
• W1986215516 cites W2071108987 @default.
• W1986215516 cites W2071234903 @default.
• W1986215516 cites W2076060028 @default.
• W1986215516 cites W2077108066 @default.
• W1986215516 cites W2078888308 @default.
• W1986215516 cites W2083328029 @default.
• W1986215516 cites W2089248086 @default.
• W1986215516 cites W2098300372 @default.
• W1986215516 cites W2102614398 @default.
• W1986215516 cites W2102622687 @default.
• W1986215516 cites W2103158810 @default.
• W1986215516 cites W2106181496 @default.
• W1986215516 cites W2115595736 @default.
• W1986215516 cites W2121684618 @default.
• W1986215516 cites W2127673401 @default.
• W1986215516 cites W2129588639 @default.
• W1986215516 cites W2149956676 @default.
• W1986215516 cites W2154216995 @default.
• W1986215516 cites W222240241 @default.
• W1986215516 doi "https://doi.org/10.1002/jbmr.326" @default.
• W1986215516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3312757" @default.
• W1986215516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21611966" @default.
• W1986215516 hasPublicationYear "2011" @default.
• W1986215516 type Work @default.
• W1986215516 sameAs 1986215516 @default.
• W1986215516 citedByCount "85" @default.
• W1986215516 countsByYear W19862155162012 @default.
• W1986215516 countsByYear W19862155162013 @default.
• W1986215516 countsByYear W19862155162014 @default.
• W1986215516 countsByYear W19862155162015 @default.
• W1986215516 countsByYear W19862155162016 @default.
• W1986215516 countsByYear W19862155162017 @default.
• W1986215516 countsByYear W19862155162018 @default.
• W1986215516 countsByYear W19862155162019 @default.
• W1986215516 countsByYear W19862155162020 @default.
• W1986215516 countsByYear W19862155162021 @default.
• W1986215516 countsByYear W19862155162022 @default.
• W1986215516 countsByYear W19862155162023 @default.
• W1986215516 crossrefType "journal-article" @default.
• W1986215516 hasAuthorship W1986215516A5002325815 @default.
• W1986215516 hasAuthorship W1986215516A5005942374 @default.
• W1986215516 hasAuthorship W1986215516A5014023359 @default.
• W1986215516 hasAuthorship W1986215516A5014645084 @default.
• W1986215516 hasAuthorship W1986215516A5015533587 @default.
• W1986215516 hasAuthorship W1986215516A5017780140 @default.
• W1986215516 hasAuthorship W1986215516A5023756240 @default.
• W1986215516 hasAuthorship W1986215516A5028500843 @default.
• W1986215516 hasAuthorship W1986215516A5029437522 @default.
• W1986215516 hasAuthorship W1986215516A5070210677 @default.
• W1986215516 hasBestOaLocation W19862155161 @default.
• W1986215516 hasConcept C104317684 @default.
• W1986215516 hasConcept C105702510 @default.
• W1986215516 hasConcept C109523444 @default.
• W1986215516 hasConcept C127561419 @default.
• W1986215516 hasConcept C134018914 @default.
• W1986215516 hasConcept C136229726 @default.
• W1986215516 hasConcept C141071460 @default.
• W1986215516 hasConcept C142724271 @default.

• next