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- W1986240693 abstract "We compared the effect of tropical application of PGF2a on cerebral arterioles in cats and rats equipped with an acutely implanted cranial window. Arterial diameter was measured using a microscope and image splitting device. PGF2a in a concentration ranging from 10−7 to 10−5 M had no effect on large (≥ 100 μm) or small (< 100 μm) cat pial arterioles, but induced a dose dependent constriction of rat pial arterioles with a maximum constriction fo 76% of control diameter. Dilation of cat large cerebral arterioles by topically applied PGE2 was not affected by simultaneous application of PGF2a and PGE2 induced dilation of small arterioles was decreased 3% by PGF2a. While we and others have previosuly shown that both cat and rat brain can synthesize PGF2a, it appears that PGF2a is not likely to normally be a major modulator of cerebral arteriolar resistance in all species." @default.
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- W1986240693 date "1983-12-01" @default.
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- W1986240693 title "The effect of PGF2a on in vivo cerebral arteriolar diameter in cats and rats" @default.
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- W1986240693 doi "https://doi.org/10.1016/0090-6980(83)90154-5" @default.
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