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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986241108> ?p ?o ?g. }

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• W1986241108 abstract "Aim: To investigate the role of β-catenin in pathogenesis of nasopharyngeal carcinoma (NPC). Methods: Cellular proliferation, apoptosis, matrix penetration assay, and western blotting were employed to determine cell biological changes in NPC cell lines transfected with β-catenin siRNA. Immunohistochemistry staining was used to detect β-catenin and Ki-67 expression in NPC tissue. Results: β-Catenin was upregulated in NPC cell lines and tissues compared with chronic nasopharyngitis tissue. β-Catenin knockdown dramatically inhibited cellular growth, migration and invasion, but induced apoptosis of NPC cells. Further study showed that downstream genes of β-catenin signaling pathway including cyclin D1, c-Myc, MMP2 and MMP9 expression were suppressed in NPC cell lines transfected with β-catenin siRNA. Conclusion: Targeting β-catenin signaling pathway may be a noval strategy for NPC therapy." @default.
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• W1986241108 date "2012-04-01" @default.
• W1986241108 modified "2023-09-23" @default.
• W1986241108 title "Suppression of nasopharyngeal carcinoma cell by targeting β-catenin signaling pathway" @default.
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• W1986241108 doi "https://doi.org/10.1016/j.canep.2011.11.002" @default.
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