FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986241621> ?p ?o ?g. }

• W1986241621 endingPage "24" @default.
• W1986241621 startingPage "14" @default.
• W1986241621 abstract "The poly (ADP-ribose) polymerase 1 (PARP-1) actively participates in a series of functions within the cell that include: mitosis, intracellular signaling, cell cycle regulation, transcription and DNA damage repair. Therefore, inhibition of PARP1 has a great potential for use in cancer therapy. As resistance to PARP inhibitors is starting to be observed in patients, thus the function of PARP-1 needs to be studied in depth in order to find new therapeutic targets. To gain more information on the PARP-1 activity, we expressed PARP-1 in yeast and investigated its effect on cell growth and UV induced homologous recombination. To identify candidate genes affecting PARP-1 activity and cellular localization, we also developed a yeast genome wide genetic screen. We found that PARP-1 strongly inhibited yeast growth, but when yeast was exposed to the PARP-1 inhibitor 6(5-H) phenantridinone (PHE), it recovered from the growth suppression. Moreover, we showed that PARP-1 produced PAR products in yeast and we demonstrated that PARP-1 reduced UV-induced homologous recombination. By genome wide screening, we identified 99 mutants that suppressed PARP-1 growth inhibition. Orthologues of human genes were found for 41 of these yeast genes. We determined whether the PARP-1 protein level was altered in strains which are deleted for the transcription regulator GAL3, the histone H1 gene HHO1, the HUL4 gene, the deubiquitination enzyme gene OTU1, the nuclear pore protein POM152 and the SNT1 that encodes for the Set3C subunit of the histone deacetylase complex. In these strains the PARP-1 level was roughly the same as in the wild type. PARP-1 localized in the nucleus more in the snt1Δ than in the wild type strain; after UV radiation, PARP-1 localized in the nucleus more in hho1 and pom152 deletion strains than in the wild type indicating that these functions may have a role on regulating PARP-1 level and activity in the nucleus." @default.
• W1986241621 created "2016-06-24" @default.
• W1986241621 creator A5001040987 @default.
• W1986241621 creator A5005574112 @default.
• W1986241621 creator A5006222101 @default.
• W1986241621 creator A5011040459 @default.
• W1986241621 creator A5049640104 @default.
• W1986241621 creator A5058538051 @default.
• W1986241621 creator A5060922784 @default.
• W1986241621 creator A5088245955 @default.
• W1986241621 date "2015-04-01" @default.
• W1986241621 modified "2023-10-16" @default.
• W1986241621 title "Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization" @default.
• W1986241621 cites W1606232948 @default.
• W1986241621 cites W1965006127 @default.
• W1986241621 cites W1968676663 @default.
• W1986241621 cites W1968960110 @default.
• W1986241621 cites W1969575940 @default.
• W1986241621 cites W1970500614 @default.
• W1986241621 cites W1972582950 @default.
• W1986241621 cites W1980436694 @default.
• W1986241621 cites W1984629445 @default.
• W1986241621 cites W1991206583 @default.
• W1986241621 cites W1993043513 @default.
• W1986241621 cites W1993702748 @default.
• W1986241621 cites W1996935079 @default.
• W1986241621 cites W2004778652 @default.
• W1986241621 cites W2010452331 @default.
• W1986241621 cites W2014215525 @default.
• W1986241621 cites W2016637704 @default.
• W1986241621 cites W2018691707 @default.
• W1986241621 cites W2023712548 @default.
• W1986241621 cites W2026642422 @default.
• W1986241621 cites W2027348804 @default.
• W1986241621 cites W2034142957 @default.
• W1986241621 cites W2036950607 @default.
• W1986241621 cites W2038591876 @default.
• W1986241621 cites W2041724332 @default.
• W1986241621 cites W2046624906 @default.
• W1986241621 cites W2049426834 @default.
• W1986241621 cites W2049436645 @default.
• W1986241621 cites W2052699691 @default.
• W1986241621 cites W2056498488 @default.
• W1986241621 cites W2056848326 @default.
• W1986241621 cites W2059349650 @default.
• W1986241621 cites W2060321052 @default.
• W1986241621 cites W2061019285 @default.
• W1986241621 cites W2061912939 @default.
• W1986241621 cites W2068517117 @default.
• W1986241621 cites W2070093424 @default.
• W1986241621 cites W2075845641 @default.
• W1986241621 cites W2075939050 @default.
• W1986241621 cites W2080036268 @default.
• W1986241621 cites W2080479901 @default.
• W1986241621 cites W2087824350 @default.
• W1986241621 cites W2091880448 @default.
• W1986241621 cites W2094170505 @default.
• W1986241621 cites W2095264331 @default.
• W1986241621 cites W2113125265 @default.
• W1986241621 cites W2113699634 @default.
• W1986241621 cites W2121303976 @default.
• W1986241621 cites W2122576785 @default.
• W1986241621 cites W2123329045 @default.
• W1986241621 cites W2124954099 @default.
• W1986241621 cites W2125134465 @default.
• W1986241621 cites W2128660010 @default.
• W1986241621 cites W2131078129 @default.
• W1986241621 cites W2137408964 @default.
• W1986241621 cites W2153349010 @default.
• W1986241621 cites W2160073632 @default.
• W1986241621 cites W2160697532 @default.
• W1986241621 cites W2163418444 @default.
• W1986241621 cites W2164708087 @default.
• W1986241621 cites W2165912346 @default.
• W1986241621 cites W2171972386 @default.
• W1986241621 cites W300133789 @default.
• W1986241621 cites W4252805882 @default.
• W1986241621 doi "https://doi.org/10.1016/j.mrfmmm.2015.02.006" @default.
• W1986241621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25779917" @default.
• W1986241621 hasPublicationYear "2015" @default.
• W1986241621 type Work @default.
• W1986241621 sameAs 1986241621 @default.
• W1986241621 citedByCount "8" @default.
• W1986241621 countsByYear W19862416212017 @default.
• W1986241621 countsByYear W19862416212018 @default.
• W1986241621 countsByYear W19862416212019 @default.
• W1986241621 countsByYear W19862416212020 @default.
• W1986241621 countsByYear W19862416212021 @default.
• W1986241621 crossrefType "journal-article" @default.
• W1986241621 hasAuthorship W1986241621A5001040987 @default.
• W1986241621 hasAuthorship W1986241621A5005574112 @default.
• W1986241621 hasAuthorship W1986241621A5006222101 @default.
• W1986241621 hasAuthorship W1986241621A5011040459 @default.
• W1986241621 hasAuthorship W1986241621A5049640104 @default.
• W1986241621 hasAuthorship W1986241621A5058538051 @default.
• W1986241621 hasAuthorship W1986241621A5060922784 @default.
• W1986241621 hasAuthorship W1986241621A5088245955 @default.
• W1986241621 hasConcept C102744134 @default.

• next