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• W1986241877 abstract "Vertebrate limbs first emerge as small buds at specific locations along the trunk. Although a fair amount is known about the molecular regulation of limb initiation and outgrowth, the cellular events underlying these processes have remained less clear. We show that the mesenchymal limb progenitors arise through localized epithelial-to-mesenchymal transition (EMT) of the coelomic epithelium specifically within the presumptive limb fields. This EMT is regulated at least in part by Tbx5 and Fgf10, two genes known to control limb initiation. This work shows that limb buds initiate earlier than previously thought, as a result of localized EMT rather than differential proliferation rates." @default.
• W1986241877 created "2016-06-24" @default.
• W1986241877 creator A5014300544 @default.
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• W1986241877 date "2014-03-14" @default.
• W1986241877 modified "2023-10-14" @default.
• W1986241877 title "Vertebrate Limb Bud Formation Is Initiated by Localized Epithelial-to-Mesenchymal Transition" @default.
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• W1986241877 doi "https://doi.org/10.1126/science.1248228" @default.
• W1986241877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4097009" @default.
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