Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986242536> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1986242536 endingPage "1715" @default.
- W1986242536 startingPage "1711" @default.
- W1986242536 abstract "Abstract Antiphospholipid antibodies represent a heterogeneous group of autoantibodies directed against anionic phospholipids (PLs) usually linked to protein cofactors. Their presence during the antiphospholipid syndrome is associated with risks of thrombosis and fetal losses. Among 5 randomly selected monoclonal antiphospholipid antibodies, all originating from a single patient suffering from this autoimmune disease, only 1 induced fetal losses when passively injected into pregnant mice. Its antiphospholipid activity was dependent on annexin A5, and its variable regions contained mainly 3 replacement mutations. To clarify the role of these mutations in the pathogenicity of the antibody, they were in vitro reverted to the germ line configuration. The resulting “germ line” antibody reacted with multiple self-antigens and only partially lost its reactivity against PLs, but it was no more dependent on annexin A5 and, more importantly, was no more pathogenic. This study illustrates that the in vivo antigen-driven maturation process of natural autoreactive B cells can be responsible for pathogenicity. (Blood. 2004;104:1711-1715)" @default.
- W1986242536 created "2016-06-24" @default.
- W1986242536 creator A5012624968 @default.
- W1986242536 creator A5013384281 @default.
- W1986242536 creator A5033331730 @default.
- W1986242536 creator A5037805281 @default.
- W1986242536 creator A5040536603 @default.
- W1986242536 creator A5047130487 @default.
- W1986242536 creator A5068913173 @default.
- W1986242536 creator A5069356033 @default.
- W1986242536 creator A5074771047 @default.
- W1986242536 date "2004-09-15" @default.
- W1986242536 modified "2023-10-14" @default.
- W1986242536 title "Pathogenic antiphospholipid antibody: an antigen-selected needle in a haystack" @default.
- W1986242536 cites W1545458002 @default.
- W1986242536 cites W1978514758 @default.
- W1986242536 cites W1981822805 @default.
- W1986242536 cites W2002611018 @default.
- W1986242536 cites W2005634587 @default.
- W1986242536 cites W2012271760 @default.
- W1986242536 cites W2015642465 @default.
- W1986242536 cites W2019650966 @default.
- W1986242536 cites W2040391992 @default.
- W1986242536 cites W204108417 @default.
- W1986242536 cites W2060554108 @default.
- W1986242536 cites W2060809301 @default.
- W1986242536 cites W2072349587 @default.
- W1986242536 cites W2074332508 @default.
- W1986242536 cites W2089024808 @default.
- W1986242536 cites W2092833137 @default.
- W1986242536 cites W2096384262 @default.
- W1986242536 cites W2097046783 @default.
- W1986242536 cites W2101831374 @default.
- W1986242536 cites W2113891001 @default.
- W1986242536 cites W2114637484 @default.
- W1986242536 cites W2142233457 @default.
- W1986242536 cites W2170752642 @default.
- W1986242536 cites W2256255199 @default.
- W1986242536 cites W4231434854 @default.
- W1986242536 cites W4244838338 @default.
- W1986242536 doi "https://doi.org/10.1182/blood-2004-02-0462" @default.
- W1986242536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15166038" @default.
- W1986242536 hasPublicationYear "2004" @default.
- W1986242536 type Work @default.
- W1986242536 sameAs 1986242536 @default.
- W1986242536 citedByCount "35" @default.
- W1986242536 countsByYear W19862425362012 @default.
- W1986242536 countsByYear W19862425362013 @default.
- W1986242536 countsByYear W19862425362016 @default.
- W1986242536 countsByYear W19862425362017 @default.
- W1986242536 countsByYear W19862425362019 @default.
- W1986242536 countsByYear W19862425362021 @default.
- W1986242536 countsByYear W19862425362023 @default.
- W1986242536 crossrefType "journal-article" @default.
- W1986242536 hasAuthorship W1986242536A5012624968 @default.
- W1986242536 hasAuthorship W1986242536A5013384281 @default.
- W1986242536 hasAuthorship W1986242536A5033331730 @default.
- W1986242536 hasAuthorship W1986242536A5037805281 @default.
- W1986242536 hasAuthorship W1986242536A5040536603 @default.
- W1986242536 hasAuthorship W1986242536A5047130487 @default.
- W1986242536 hasAuthorship W1986242536A5068913173 @default.
- W1986242536 hasAuthorship W1986242536A5069356033 @default.
- W1986242536 hasAuthorship W1986242536A5074771047 @default.
- W1986242536 hasConcept C147483822 @default.
- W1986242536 hasConcept C159654299 @default.
- W1986242536 hasConcept C163764329 @default.
- W1986242536 hasConcept C203014093 @default.
- W1986242536 hasConcept C2776874634 @default.
- W1986242536 hasConcept C71924100 @default.
- W1986242536 hasConcept C86803240 @default.
- W1986242536 hasConceptScore W1986242536C147483822 @default.
- W1986242536 hasConceptScore W1986242536C159654299 @default.
- W1986242536 hasConceptScore W1986242536C163764329 @default.
- W1986242536 hasConceptScore W1986242536C203014093 @default.
- W1986242536 hasConceptScore W1986242536C2776874634 @default.
- W1986242536 hasConceptScore W1986242536C71924100 @default.
- W1986242536 hasConceptScore W1986242536C86803240 @default.
- W1986242536 hasIssue "6" @default.
- W1986242536 hasLocation W19862425361 @default.
- W1986242536 hasLocation W19862425362 @default.
- W1986242536 hasOpenAccess W1986242536 @default.
- W1986242536 hasPrimaryLocation W19862425361 @default.
- W1986242536 hasRelatedWork W178914116 @default.
- W1986242536 hasRelatedWork W1958625084 @default.
- W1986242536 hasRelatedWork W1977645254 @default.
- W1986242536 hasRelatedWork W2040191638 @default.
- W1986242536 hasRelatedWork W2101875571 @default.
- W1986242536 hasRelatedWork W2146466204 @default.
- W1986242536 hasRelatedWork W2408448934 @default.
- W1986242536 hasRelatedWork W2425255793 @default.
- W1986242536 hasRelatedWork W2980667736 @default.
- W1986242536 hasRelatedWork W2502283878 @default.
- W1986242536 hasVolume "104" @default.
- W1986242536 isParatext "false" @default.
- W1986242536 isRetracted "false" @default.
- W1986242536 magId "1986242536" @default.
- W1986242536 workType "article" @default.