FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986242787> ?p ?o ?g. }

• W1986242787 endingPage "71" @default.
• W1986242787 startingPage "63" @default.
• W1986242787 abstract "Fibronectin (Fn) forms a fibrillar network that controls cell behavior in both physiological and diseased conditions including cancer. Indeed, breast cancer-associated stromal cells not only increase the quantity of deposited Fn but also modify its conformation. However, (i) the interplay between mechanical and conformational properties of early tumor-associated Fn networks and (ii) its effect on tumor vascularization remain unclear. Here, we first used the Surface Forces Apparatus to reveal that 3T3-L1 preadipocytes exposed to tumor-secreted factors generate a stiffer Fn matrix relative to control cells. We then show that this early matrix stiffening correlates with increased molecular unfolding in Fn fibers, as determined by Förster Resonance Energy Transfer. Finally, we assessed the resulting changes in adhesion and proangiogenic factor (VEGF) secretion of newly seeded 3T3-L1s, and we examined altered integrin specificity as a potential mechanism of modified cell–matrix interactions through integrin blockers. Our data indicate that tumor-conditioned Fn decreases adhesion while enhancing VEGF secretion by preadipocytes, and that an integrin switch is responsible for such changes. Collectively, our findings suggest that simultaneous stiffening and unfolding of initially deposited tumor-conditioned Fn alters both adhesion and proangiogenic behavior of surrounding stromal cells, likely promoting vascularization and growth of the breast tumor. This work enhances our knowledge of cell – Fn matrix interactions that may be exploited for other biomaterials-based applications, including advanced tissue engineering approaches." @default.
• W1986242787 created "2016-06-24" @default.
• W1986242787 creator A5025265276 @default.
• W1986242787 creator A5039784368 @default.
• W1986242787 creator A5041231978 @default.
• W1986242787 creator A5064657173 @default.
• W1986242787 creator A5076675882 @default.
• W1986242787 creator A5090690232 @default.
• W1986242787 date "2015-06-01" @default.
• W1986242787 modified "2023-09-26" @default.
• W1986242787 title "Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells" @default.
• W1986242787 cites W128409938 @default.
• W1986242787 cites W1580675778 @default.
• W1986242787 cites W1584141172 @default.
• W1986242787 cites W1887076575 @default.
• W1986242787 cites W1966498333 @default.
• W1986242787 cites W1969599616 @default.
• W1986242787 cites W1972914996 @default.
• W1986242787 cites W1973800056 @default.
• W1986242787 cites W1979704965 @default.
• W1986242787 cites W1982447134 @default.
• W1986242787 cites W1986225001 @default.
• W1986242787 cites W1990387345 @default.
• W1986242787 cites W1993006648 @default.
• W1986242787 cites W1999765951 @default.
• W1986242787 cites W2001103206 @default.
• W1986242787 cites W2001864588 @default.
• W1986242787 cites W2004207209 @default.
• W1986242787 cites W2005165360 @default.
• W1986242787 cites W2005869751 @default.
• W1986242787 cites W2007719816 @default.
• W1986242787 cites W2007876874 @default.
• W1986242787 cites W2010291978 @default.
• W1986242787 cites W2011217812 @default.
• W1986242787 cites W2017185723 @default.
• W1986242787 cites W2018244125 @default.
• W1986242787 cites W2022487696 @default.
• W1986242787 cites W2023412716 @default.
• W1986242787 cites W2023989365 @default.
• W1986242787 cites W2029551351 @default.
• W1986242787 cites W2030335451 @default.
• W1986242787 cites W2032392940 @default.
• W1986242787 cites W2033998652 @default.
• W1986242787 cites W2041635943 @default.
• W1986242787 cites W2049387285 @default.
• W1986242787 cites W2056554708 @default.
• W1986242787 cites W2058507407 @default.
• W1986242787 cites W2059476028 @default.
• W1986242787 cites W2071975241 @default.
• W1986242787 cites W2072676689 @default.
• W1986242787 cites W2074405834 @default.
• W1986242787 cites W2078338424 @default.
• W1986242787 cites W2082634393 @default.
• W1986242787 cites W2086244192 @default.
• W1986242787 cites W2087620960 @default.
• W1986242787 cites W2093508488 @default.
• W1986242787 cites W2094007386 @default.
• W1986242787 cites W2094434540 @default.
• W1986242787 cites W2099052265 @default.
• W1986242787 cites W2100303404 @default.
• W1986242787 cites W2103722820 @default.
• W1986242787 cites W2104479723 @default.
• W1986242787 cites W2105300288 @default.
• W1986242787 cites W2111724224 @default.
• W1986242787 cites W2122917672 @default.
• W1986242787 cites W2124903948 @default.
• W1986242787 cites W2132566055 @default.
• W1986242787 cites W2136737404 @default.
• W1986242787 cites W2139921980 @default.
• W1986242787 cites W2141080137 @default.
• W1986242787 cites W2141815918 @default.
• W1986242787 cites W2142677837 @default.
• W1986242787 cites W2152002380 @default.
• W1986242787 cites W2157012084 @default.
• W1986242787 cites W2159835158 @default.
• W1986242787 cites W2161214210 @default.
• W1986242787 cites W2161422731 @default.
• W1986242787 cites W2163187600 @default.
• W1986242787 cites W2170492618 @default.
• W1986242787 cites W2476542314 @default.
• W1986242787 doi "https://doi.org/10.1016/j.biomaterials.2015.03.019" @default.
• W1986242787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4659482" @default.
• W1986242787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25907040" @default.
• W1986242787 hasPublicationYear "2015" @default.
• W1986242787 type Work @default.
• W1986242787 sameAs 1986242787 @default.
• W1986242787 citedByCount "69" @default.
• W1986242787 countsByYear W19862427872015 @default.
• W1986242787 countsByYear W19862427872016 @default.
• W1986242787 countsByYear W19862427872017 @default.
• W1986242787 countsByYear W19862427872018 @default.
• W1986242787 countsByYear W19862427872019 @default.
• W1986242787 countsByYear W19862427872020 @default.
• W1986242787 countsByYear W19862427872021 @default.
• W1986242787 countsByYear W19862427872022 @default.
• W1986242787 countsByYear W19862427872023 @default.
• W1986242787 crossrefType "journal-article" @default.
• W1986242787 hasAuthorship W1986242787A5025265276 @default.

• next