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- W1986243953 abstract "The effects of an antidiarrhoel agent, loperamide, were studied using isolated guinea pig taeni coli. Loperamide in concentrations ranging from 10−7 M to 10−6 M inhibited the cholinergic, contractile responses induced by electrical transmural stimulation, nicotine and serotonin, and the nonadrenergic, relaxing responses induced by electrical transmural stimualtion and nicotine. However,t he adrenergic responses to perivascular nerve stimulation was not affectesd by these concentrations. The inhibitory effects of loperamide were not reversed by washing with a drug-free solution. Morphine (10−6 M to 10−5 M) also inhibited both cholinergic and nonadrenergic responses, but the effect was reversible. Naloxone (10−6 M) attenuated the inhibitory effects of both drugs. Unlike morphine, loperamide in concentrations higher than 5 × 10−6 M relaxed the strips and reduced the contractile response to acetylcholine noncempetitively, and these effects were not blocked by naloxone. These results suggest that loperamide at low concentration acts selectively ont he opiate receptors located in both cholinergic and of the intestinal tone." @default.
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- W1986243953 date "1979-04-01" @default.
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- W1986243953 title "Effects of loperamide on the guinea pig taenia coli" @default.
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- W1986243953 doi "https://doi.org/10.1016/0014-2999(79)90390-x" @default.
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