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• W1986245599 abstract "Abstract The 14‐3‐3 proteins are known to play an important regulatory role in apoptosis, and various cell signaling cascades. However, no investigation on mosquito 14‐3‐3 has been reported. To investigate the role of 14‐3‐3 proteins in mosquito midgut cells undergoing apoptosis, we decided to take advantage of Anopheles gambiae genome data, and were able to find Ag14‐3‐3ζ cDNA and protein sequences from Ensembl ( http://www.ensembl.org ). Further in silico analysis using BLAST search revealed that Ag14‐3‐3ζ protein is a polypeptide of 248 amino acids, and shares high identity with 14‐3‐3ζ homologues from Aedes aegypti (100%), Drosophila melanogaster (96%) and Bombyx mori (93%). Due to the perfect match and high homology, we hypothesized that Ag14‐3‐3ζ peptide antibody may recognize 14‐3‐3ζ homologs from other anopheline mosquitoes and insects. We thus generated 14‐3‐3ζ polyclonal antibody against a unique region located in the C‐terminal end of Ag14‐3‐3ζ after in silico epitope analysis. As expected, zoo‐western blot analysis of 14‐3‐3 proteins revealed that a polyclonal antibody against Ag14‐3‐3ζ peptide recognizes 14‐3‐3 homologs from dipteran and lepidopteran insects. To our knowledge, this is the first report on polyclonal antibody production against mosquito 14‐3‐3ζ. The mosquito‐based 14‐3‐3ζ antibody will be very useful for studying the functional characterization of 14‐3‐3ζ in the context of host–pathogen interactions in midgut and other immune cells." @default.
• W1986245599 created "2016-06-24" @default.
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• W1986245599 date "2009-03-01" @default.
• W1986245599 modified "2023-10-16" @default.
• W1986245599 title "Peptide-based polyclonal antibody against mosquito 14-3-3ζ recognizes 14-3-3 homolog from dipteran and lepidopteran insects" @default.
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• W1986245599 doi "https://doi.org/10.1111/j.1748-5967.2009.00214.x" @default.
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