Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986246916> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1986246916 endingPage "347" @default.
- W1986246916 startingPage "339" @default.
- W1986246916 abstract "Retinoblastoma affects approximately 40 children in Germany per year. Most children are diagnosed early with localized intraocular disease, and the overall survival rate exceeds 95%. However, the prognosis of metastasized retinoblastoma remains poor. In 40% of the patients, retinoblastoma occurs bilaterally and, especially for these children, the salvage of the eye and visual function is of major importance. The variety of conservative treatment options for localized retinoblastoma includes laser coagulation, thermotherapy, cryotherapy, brachytherapy and chemotherapy. While systemic chemotherapy has nearly completely replaced external beam radiotherapy in the primary treatment of intraocular retinoblastoma, intra-arterial, intravitreal and periocular application of chemotherapy was also shown to be effective in treating intraocular retinoblastoma in case series. Genetic testing is an integral part of the routine diagnostics of all patients. Available tumor material should be analyzed to detect mutational mosaicism, that affects >10% of children with unilateral retinoblastoma. Genetic testing also identifies children with heritable (50% of patients) retinoblastoma. These children have a genetic predisposition for second malignancies. For this reason, late effects are an increasing concern and the care of patients with retinoblastoma requires a multidisciplinary approach to tailor therapy and long-term follow-up. Multicenter clinical trials are being developed to evaluate evidence-based treatment concepts for localized and metastasized retinoblastoma to improve survival rates and quality of life of children with retinoblastoma." @default.
- W1986246916 created "2016-06-24" @default.
- W1986246916 creator A5006938964 @default.
- W1986246916 creator A5030466425 @default.
- W1986246916 creator A5059343286 @default.
- W1986246916 creator A5069955866 @default.
- W1986246916 creator A5070310426 @default.
- W1986246916 creator A5072765562 @default.
- W1986246916 date "2012-11-09" @default.
- W1986246916 modified "2023-09-27" @default.
- W1986246916 title "Current Concepts for Diagnosis and Treatment of Retinoblastoma in Germany: Aiming for Safe Tumor Control and Vision Preservation" @default.
- W1986246916 doi "https://doi.org/10.1055/s-0032-1327563" @default.
- W1986246916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23143761" @default.
- W1986246916 hasPublicationYear "2012" @default.
- W1986246916 type Work @default.
- W1986246916 sameAs 1986246916 @default.
- W1986246916 citedByCount "20" @default.
- W1986246916 countsByYear W19862469162013 @default.
- W1986246916 countsByYear W19862469162014 @default.
- W1986246916 countsByYear W19862469162015 @default.
- W1986246916 countsByYear W19862469162016 @default.
- W1986246916 countsByYear W19862469162017 @default.
- W1986246916 countsByYear W19862469162018 @default.
- W1986246916 countsByYear W19862469162019 @default.
- W1986246916 countsByYear W19862469162021 @default.
- W1986246916 countsByYear W19862469162022 @default.
- W1986246916 crossrefType "journal-article" @default.
- W1986246916 hasAuthorship W1986246916A5006938964 @default.
- W1986246916 hasAuthorship W1986246916A5030466425 @default.
- W1986246916 hasAuthorship W1986246916A5059343286 @default.
- W1986246916 hasAuthorship W1986246916A5069955866 @default.
- W1986246916 hasAuthorship W1986246916A5070310426 @default.
- W1986246916 hasAuthorship W1986246916A5072765562 @default.
- W1986246916 hasConcept C104317684 @default.
- W1986246916 hasConcept C141071460 @default.
- W1986246916 hasConcept C185592680 @default.
- W1986246916 hasConcept C187212893 @default.
- W1986246916 hasConcept C2776577112 @default.
- W1986246916 hasConcept C2776694085 @default.
- W1986246916 hasConcept C2780149145 @default.
- W1986246916 hasConcept C509974204 @default.
- W1986246916 hasConcept C54355233 @default.
- W1986246916 hasConcept C55493867 @default.
- W1986246916 hasConcept C71924100 @default.
- W1986246916 hasConcept C80227256 @default.
- W1986246916 hasConcept C86803240 @default.
- W1986246916 hasConceptScore W1986246916C104317684 @default.
- W1986246916 hasConceptScore W1986246916C141071460 @default.
- W1986246916 hasConceptScore W1986246916C185592680 @default.
- W1986246916 hasConceptScore W1986246916C187212893 @default.
- W1986246916 hasConceptScore W1986246916C2776577112 @default.
- W1986246916 hasConceptScore W1986246916C2776694085 @default.
- W1986246916 hasConceptScore W1986246916C2780149145 @default.
- W1986246916 hasConceptScore W1986246916C509974204 @default.
- W1986246916 hasConceptScore W1986246916C54355233 @default.
- W1986246916 hasConceptScore W1986246916C55493867 @default.
- W1986246916 hasConceptScore W1986246916C71924100 @default.
- W1986246916 hasConceptScore W1986246916C80227256 @default.
- W1986246916 hasConceptScore W1986246916C86803240 @default.
- W1986246916 hasIssue "06" @default.
- W1986246916 hasLocation W19862469161 @default.
- W1986246916 hasLocation W19862469162 @default.
- W1986246916 hasOpenAccess W1986246916 @default.
- W1986246916 hasPrimaryLocation W19862469161 @default.
- W1986246916 hasRelatedWork W114212789 @default.
- W1986246916 hasRelatedWork W1963495825 @default.
- W1986246916 hasRelatedWork W1992065691 @default.
- W1986246916 hasRelatedWork W2006607280 @default.
- W1986246916 hasRelatedWork W2073573774 @default.
- W1986246916 hasRelatedWork W2334205130 @default.
- W1986246916 hasRelatedWork W2388686717 @default.
- W1986246916 hasRelatedWork W2411509099 @default.
- W1986246916 hasRelatedWork W2473332486 @default.
- W1986246916 hasRelatedWork W2991475447 @default.
- W1986246916 hasVolume "224" @default.
- W1986246916 isParatext "false" @default.
- W1986246916 isRetracted "false" @default.
- W1986246916 magId "1986246916" @default.
- W1986246916 workType "article" @default.