FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986253871> ?p ?o ?g. }

• W1986253871 endingPage "396" @default.
• W1986253871 startingPage "390" @default.
• W1986253871 abstract "Riviere, J.E., Frazier, D.L. & Tippitt, W.L. Pharmacokinetic estimation for therapeutic dosage regimens (PETDR) – a software program designed to determine intravenous drug dosage regimens for veterinary applications. J. vet. Pharmacol. Therap. 11, 390–396. Pharmacokinetic estimation for therapeutic dosage regimens (PETDR) is a software program used to design individualized intravenous dosage regimens, determine concentration–time profiles, predict serum concentrations at a specific time after intravenous dosing and predict the time after the last dose to achieve a specified concentration of drug. The reference pharmacokinetic parameters may be based on an individual anima's pharmacokinetic disposition of drug or on FARAD (Food Animal Residue Avoidance Databank) mean population kinetic parameters. An individual anima's kinetic parameters may be input for predetermined analysis or the program can calculate these values by input of raw serum concentration–time data. The program allows the user to specify certain parameters of the dosage regimen, then calculates the other parameters (given desired maximum and minimum serum concentrations, dose and interval are calculated; given desired maximum serum concentration and interval, dose is calculated, etc.). Given the kinetic parameters, the dose and dosing interval, the program calculates and plots the serum concentration-time profile of the drug for that animal. The time and the number of doses to reach steady state can be calculated as well as the determination of loading dose. The percentage of the time of a dosing interval at steady state that the serum concentration is above a specific minimum inhibitory concentration (MIC) allows evaluation of efficacy of an antimicrobial regimen. Similarly, the time to reach a specific concentration (e.g. residue tolerance) or the MIC of a drug can be calculated. Legal tissue tolerances can be accessed from FARAD to aid in predicting for what period of time illegal residues will remain in the animal. These calculations allow design of dosage regimens that maximize therapeutic efficacy and minimize toxicity to the patient as well as to decrease the incidence of drug residues in food animals." @default.
• W1986253871 created "2016-06-24" @default.
• W1986253871 creator A5010469020 @default.
• W1986253871 creator A5073410418 @default.
• W1986253871 creator A5078395410 @default.
• W1986253871 date "1988-12-01" @default.
• W1986253871 modified "2023-10-18" @default.
• W1986253871 title "Pharmacokinetic estimation for therapeutic dosage regimens (PETDR) – a software program designed to determine intravenous drug dosage regimens for veterinary applications" @default.
• W1986253871 cites W1979955365 @default.
• W1986253871 cites W1990623971 @default.
• W1986253871 cites W1991978900 @default.
• W1986253871 cites W2000774007 @default.
• W1986253871 cites W2011818075 @default.
• W1986253871 cites W2019377668 @default.
• W1986253871 cites W2042099048 @default.
• W1986253871 cites W2046988336 @default.
• W1986253871 cites W2149685695 @default.
• W1986253871 cites W2502670554 @default.
• W1986253871 cites W2557504661 @default.
• W1986253871 doi "https://doi.org/10.1111/j.1365-2885.1988.tb00199.x" @default.
• W1986253871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3210265" @default.
• W1986253871 hasPublicationYear "1988" @default.
• W1986253871 type Work @default.
• W1986253871 sameAs 1986253871 @default.
• W1986253871 citedByCount "4" @default.
• W1986253871 crossrefType "journal-article" @default.
• W1986253871 hasAuthorship W1986253871A5010469020 @default.
• W1986253871 hasAuthorship W1986253871A5073410418 @default.
• W1986253871 hasAuthorship W1986253871A5078395410 @default.
• W1986253871 hasConcept C112705442 @default.
• W1986253871 hasConcept C126322002 @default.
• W1986253871 hasConcept C141071460 @default.
• W1986253871 hasConcept C19831878 @default.
• W1986253871 hasConcept C2777288759 @default.
• W1986253871 hasConcept C2780035454 @default.
• W1986253871 hasConcept C2781413609 @default.
• W1986253871 hasConcept C2908647359 @default.
• W1986253871 hasConcept C44249647 @default.
• W1986253871 hasConcept C71924100 @default.
• W1986253871 hasConcept C77281830 @default.
• W1986253871 hasConcept C98274493 @default.
• W1986253871 hasConcept C99454951 @default.
• W1986253871 hasConceptScore W1986253871C112705442 @default.
• W1986253871 hasConceptScore W1986253871C126322002 @default.
• W1986253871 hasConceptScore W1986253871C141071460 @default.
• W1986253871 hasConceptScore W1986253871C19831878 @default.
• W1986253871 hasConceptScore W1986253871C2777288759 @default.
• W1986253871 hasConceptScore W1986253871C2780035454 @default.
• W1986253871 hasConceptScore W1986253871C2781413609 @default.
• W1986253871 hasConceptScore W1986253871C2908647359 @default.
• W1986253871 hasConceptScore W1986253871C44249647 @default.
• W1986253871 hasConceptScore W1986253871C71924100 @default.
• W1986253871 hasConceptScore W1986253871C77281830 @default.
• W1986253871 hasConceptScore W1986253871C98274493 @default.
• W1986253871 hasConceptScore W1986253871C99454951 @default.
• W1986253871 hasIssue "4" @default.
• W1986253871 hasLocation W19862538711 @default.
• W1986253871 hasLocation W19862538712 @default.
• W1986253871 hasOpenAccess W1986253871 @default.
• W1986253871 hasPrimaryLocation W19862538711 @default.
• W1986253871 hasRelatedWork W1969876219 @default.
• W1986253871 hasRelatedWork W1976159180 @default.
• W1986253871 hasRelatedWork W2004325424 @default.
• W1986253871 hasRelatedWork W2049819497 @default.
• W1986253871 hasRelatedWork W2400461952 @default.
• W1986253871 hasRelatedWork W2420918848 @default.
• W1986253871 hasRelatedWork W2626709117 @default.
• W1986253871 hasRelatedWork W2793520024 @default.
• W1986253871 hasRelatedWork W2809998795 @default.
• W1986253871 hasRelatedWork W4205993769 @default.
• W1986253871 hasVolume "11" @default.
• W1986253871 isParatext "false" @default.
• W1986253871 isRetracted "false" @default.
• W1986253871 magId "1986253871" @default.
• W1986253871 workType "article" @default.