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- W1986266148 abstract "The dopaminergic neurotransmitter system is critically involved in promoting plasticity in auditory cortex. We combined functional magnetic resonance imaging (fMRI) and a pharmacological manipulation to investigate dopaminergic modulation of neural activity in auditory cortex during instrumental learning. Volunteers either received 100 mg L-dopa (Madopar) or placebo in an appetitive, differential instrumental conditioning paradigm, which involved learning that a specific category of frequency modulated tones predicts a monetary reward when fast responses were made in a subsequent reaction time task. The other category of frequency modulated tones was not related to a reward. Our behavioral data provides evidence that dopaminergic stimulation differentially impacts on the speed of instrumental responding in rewarded and unrewarded trials. L-dopa increased neural BOLD activity in left auditory cortex to tones in rewarded and unrewarded trials. This increase was related to plasma L-dopa levels and learning rate. Our data thus provides evidence for dopaminergic modulation of neural activity in auditory cortex, which occurs for both auditory stimuli related to a later reward and those not related to a reward." @default.
- W1986266148 created "2016-06-24" @default.
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- W1986266148 date "2012-12-21" @default.
- W1986266148 modified "2023-10-18" @default.
- W1986266148 title "Effects of L-dopa during Auditory Instrumental Learning in Humans" @default.
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- W1986266148 doi "https://doi.org/10.1371/journal.pone.0052504" @default.
- W1986266148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3528678" @default.
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