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- W1986272013 abstract "Diffusion of the transmitter in the synaptic cleft critically influences the amplitude and the time course of quantal events and thus strongly affects the synaptic efficacy. However, the value of the diffusion constant remains speculative. In a confined space diffusion of ions and molecules should in general be slower as they do not move exclusively in their solvated space, but also interact with walls of the synaptic cleft, which are fixed. Indeed molecular dynamics simulations demonstrated that the diffusion of glutamate- (and water) in the cleft formed by two single wall carbon sheets is slower, but only for clefts narrower than those of synapses in the central nervous system. To provide a more realistic assessment we simulate the diffusion of glutamate- (and water) in the cleft formed by lipid bilayers. The glutamate- molecules are layered near the bilayer, and partly interdigitate with it, and the interfacial glutamate--bilayer interactions modulate the speed of glutamate diffusion. Water molecules also interdigitate with the bilayer, which masks the layering near the bilayer. The diffusion of glutamate and water in the cleft bound by lipid bilayers is influenced by factors similar to those observed in the cleft bound by carbon sheets - cleft separation and charge on the atoms of the wall. Finally, the movement of atoms of the lipid bilayer (evaluated by ‘freezing’ the positions of all atoms of the bilayer) also affects the diffusion of glutamate- and water. In conclusion this study provides a more realistic evaluation of spatial distribution and diffusion of glutamate- and water in the synaptic cleft and how they are influenced by the interactions with the membrane." @default.
- W1986272013 created "2016-06-24" @default.
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- W1986272013 date "2009-02-01" @default.
- W1986272013 modified "2023-10-05" @default.
- W1986272013 title "Molecular Dynamics Simulations Of Glutamate Diffusion In Membrane Bound Synaptic Cleft" @default.
- W1986272013 doi "https://doi.org/10.1016/j.bpj.2008.12.1328" @default.
- W1986272013 hasPublicationYear "2009" @default.
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