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• W1986272912 abstract "We have developed a strain of the tuberculosis vaccine Mycobacterium bovis bacille Calmette Guerin (BCG) that secretes high levels of a fusion protein comprising the immunodominant Mycobacterium tuberculosis Ag85B and ESAT-6 (BCG85B-ES). Mice vaccinated with BCG85B-ES were significantly better protected in the lung against aerosol infection with virulent M. tuberculosis than animals immunized with control BCG. The growth characteristic of BCG85B-ES in host tissue was identical to control BCG, suggesting the improved protective efficacy was directly related to the expression of the Ag85B-ESAT-6 fusion protein. These results suggest that BCG85B-ES warrants further investigation to determine its suitability to control tuberculosis in humans." @default.
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• W1986272912 date "2005-02-01" @default.
• W1986272912 modified "2023-10-10" @default.
• W1986272912 title "Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection" @default.
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• W1986272912 doi "https://doi.org/10.1016/j.vaccine.2004.10.007" @default.
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